Fridays for Future's Disruptive Potential: an Inconvenient Youth Between Moderate and Radical Ideas

In December 2015, political leaders celebrated the Paris Agreement as a milestone in the global fight against climate change. Three years later, Greta Thunberg's school strike outside the Swedish parliament inspired thousands of students around the world to protest against their political leaders' inability to adequately respond to climate change. Envisioning livable climate futures for generations to come, the emerging “Fridays for Future” (FFF) movement urges governments to take more radical action on climate change. While FFF has sparked discussions about climate change around the world, the movement's effects on broader societal change remain unclear. We, therefore, explore how FFF has triggered debates beyond the necessity to tackle climate change and offer a framework to reflect upon the broader socio-political implications of the school strikes. We illustrate the contestation between different ideas of social life and political order encapsulated within and attached to FFF by analyzing the movement's self-understanding and the media discourse around these protests in Germany. Although the German government portrays the country as a pioneer in moving an industry-based economy toward decarbonization, the school strikes have quickly emerged and stabilized. We explore if and how the FFF protestors express not only the need for climate action but also call for deeper societal transformation. To do so, our study draws upon a discourse analysis based on news articles, official documents, and speeches, complemented by qualitative interviews with youth representatives and experts involved in the movement to identify competing imaginaries and themes of contestation. We study the tensions between competing student-led visions of the future through the lens of sociotechnical imaginaries, which allows us to illuminate and juxtapose moderate and radical approaches. In conclusion, current school protests are not only about climate action but reflect more fundamental political struggles about competing visions of a future society in times of climate change. Yet, the protestors' strong focus on science-driven politics risks to overshadow these broader societal debates, potentially stabilizing the techno-centric, apolitical and market-driven rationale behind climate action

How power affects policy implementation: lessons from the Philippines

This article unveils how the complex multilevel governance system of a developing country affects environmental policy implementation. The Philippine Renewable Energy Act is discussed as an in-depth case study. The law was passed in 2008 to increase the share of renewables in the electricity mix, but its implementation remains a challenge. Analysing the complex multilevel governance system of the Philippines, this article shows how interjurisdictional coordination and the distribution of power resources and capacities affect the implementation process. This qualitative research is based on key documents and insights from 48 expert interviews. From a theoretical perspective, research about power in central-local relations can make a useful contribution to current multilevel governance concepts

The 2030 Agenda for Sustainable Development: Transformative Change through the Sustainable Development Goals?

The 2030 Agenda of the United Nations comprises 17 Sustainable Development Goals (SDGs) and 169 sub-targets which serve as a global reference point for the transition to sustainability. The agenda acknowledges that different issues such as poverty, hunger, health, education, gender equality, environmental degradation, among others, are intertwined and can therefore only be addressed together. Implementing the SDGs as an ‘indivisible whole’ represents the actual litmus test for the success of the 2030 Agenda. The main challenge is accomplishing a more integrated approach to sustainable development that encompasses new governance frameworks for enabling and managing systemic transformations. This thematic issue addresses the question whether and how the SDGs set off processes of societal transformation, for which cooperation between state and non-state actors at all political levels (global, regional, national, sub-national), in different societal spheres (politics, society, and economy), and across various sectors (energy, transportation, food, etc.) are indispensable. In this editorial, we first introduce the 2030 Agenda and the SDGs by providing an overview of the architecture of the agenda and the key challenges of the current implementation phase. In a second step, we present the eleven contributions that make up the thematic issue clustering them around three themes: integration, governance challenges, and implementation

Non‐ and sub‐state climate action after Paris: From a facilitative regime to a contested governance landscape

The Paris Agreement marks a significant milestone in international climate politics. With its adoption, Parties call for non‐ and sub‐state actors to contribute to the global climate agenda and close the emissions gap left by states. Such a facilitative setting embraces non‐state climate action through joint efforts, synergies, and different modes of collaboration. At the same time, non‐state actors have always played a critical and confrontational role in international climate governance. Based on a systematic literature review, we identify and critically assess the role of non‐state climate action in a facilitative post‐Paris climate governance regime. We thereby highlight three constitutive themes, namely different state‐non‐state relations, competing level of ambition, and a variety of knowledge foundations. We substantiate these themes, derived from an inductive analysis of existing literature, with illustrative examples and propose three paradigmatic non‐state actor roles in post‐Paris climate governance on a continuum between compliance and critique. We thereby highlight four particular threats of a facilitative setting, namely substitution of state action, co‐optation, tokenism, and depoliticization. Future research should not limit itself to an effective integration of NSSAs into a facilitative climate regime, but also engage with the merits of contestation

PRMT5 Mediated HIF1α Signaling and Ras-Related Nuclear Protein as Promising Biomarker in Hepatocellular Carcinoma

Protein arginine N-methyltransferase 5 (PRMT5) has been identified as a potential therapeutic target for various cancer types. However, its role in regulating the hepatocellular carcinoma (HCC) transcriptome remains poorly understood. In this study, publicly available databases were employed to investigate PRMT5 expression, its correlation with overall survival, targeted pathways, and genes of interest in HCC. Additionally, we utilized in-house generated NGS data to explore PRMT5 expression in dysplastic nodules compared to hepatocellular carcinoma. Our findings revealed that PRMT5 is significantly overexpressed in HCC compared to normal liver, and elevated expression correlates with poor overall survival. To gain insights into the mechanism driving PRMT5 overexpression in HCC, we analyzed promoter CpG islands and methylation status in HCC compared to normal tissues. Pathway analysis of PRMT5 knockdown in the HCC cells revealed a connection between PRMT5 expression and genes related to the HIF1α pathway. Additionally, by filtering PRMT5-correlated genes within the HIF1α pathway and selecting up/downregulated genes in HCC patients, we identified Ras-related nuclear protein (RAN) as a target associated with overall survival. For the first time, we report that PRMT5 is implicated in the regulation of HIF1A and RAN genes, suggesting the potential prognostic utility of PRMT5 in HCC.</p

The influence of annealings on structure and microhardness of Fe-Mo-V-Nb-C steel processed by high-pressure torsion

The influence of high-pressure torsion on microstructure, microhardness and thermal stability of lowcarbon steel Fe-0,1Mo-0,6Mn-0,8Cr-0,2Ni-0,3Si-0,2Cu-0,1V-0,06Nb-0,09C, (wt.%) was investigated. It was shown that ultrafine-grained structure formed by high-pressure torsion possesses a high microhardness (H[mu]=7,0 GPa) and high thermal stability up to the temperature of 400°С

The Coordination Chemistry of the Phosphanylborane (C6H5)2PBH2·N(CH3)3 towards Copper(I) salts

The reactions of the phosphinoborane Ph2PBH2 center dot NMe3 with Cu-(I) halides [CuCl, CuBr, CuI] and [Cu(CH3CN)(4)BF4], respectively, were studied. Depending on the ratio of the reactants used, the former reaction allowed for the synthesis of eight neutral coordination compounds with the general formula [CunXn(Ph2PBH2 center dot NMe3)(m)] (X = Cl, Br, I; n = 1, 2, 4, 5; m = 2, 4) (4-11). The latter reaction, however, led to the formation of the homoleptic complex [Cu(Ph2PBH2 center dot NMe3)(3)][BF4] (13). The structures of the products 4-11 and 13 were compared to related complexes possessing the well-known Ph3P ligand. All compounds were characterized by single crystal X-ray structure analysis, multinuclear NMR spectroscopy, IR spectroscopy and mass spectrometry

Обоснование выбора электродвигателя и схемы его включения для системы точного поддержания скорости

Рассматривается применение в системах точного поддержания скорости различных синхронных электродвигателей. В результате сравнения рекомендовано применение в таких системах конденсаторного синхронного реактивного двигателя с трехфазными обмотками статора. Это позволяет упростить и удешевить систему точного электропривода и повысить ее надежность

City refuse compost and sodium dodecyl sulphate as modifiers of diazinon leaching in soil

Spanish "Comisi6n Interminterial de Ciencia y Tecnologia" (Projet AMB94-0688). Consejo Superior de Investigaciones Científicas (CSIC.Peer reviewe