367 research outputs found
2236 Assessment of ocular reactions to dander in a cat room: Efficacy of topical ketorolac and oral terfenadine
Spin dependent photoelectron tunnelling from GaAs into magnetic Cobalt
The spin dependence of the photoelectron tunnel current from free standing
GaAs films into out-of- plane magnetized Cobalt films is demonstrated. The
measured spin asymmetry (A) resulting from a change in light helicity, reaches
+/- 6% around zero applied tunnel bias and drops to +/- 2% at a bias of -1.6 V
applied to the GaAs. This decrease is a result of the drop in the photoelectron
spin polarization that results from a reduction in the GaAs surface
recombination velocity. The sign of A changes with that of the Cobalt
magnetization direction. In contrast, on a (nonmagnetic) Gold film A ~ 0%
PO-0958: Locally advanced cervical cancer treated with IGABT: impact of the D90 HR-CTV on patterns of relapse
NOONAN’S SYNDROME
The clinical case an adult patient with rare genetically heterogeneous disorder combine with congenital heart diseases and multiple stigmas of disembryogenesis, currently presenting mostly with signs of pulmonary hypertension have been reviewed. Patient is presented with definitive Noonan’s syndrome according scoring system of Van Der Burgt (has 2 major criteria). The data of the laboratory and instrumental diagnostic methods, clinical diagnosis, selection of the optimized treatment and modification of the habit of life are given
Genetic cartography of longevity in humans and mice: Current landscape and horizons.
Aging is a complex and highly variable process. Heritability of longevity among humans and other species is low, and this finding has given rise to the idea that it may be futile to search for DNA variants that modulate aging. We argue that the problem in mapping longevity genes is mainly one of low power and the genetic and environmental complexity of aging. In this review we highlight progress made in mapping genes and molecular networks associated with longevity, paying special attention to work in mice and humans. We summarize 40years of linkage studies using murine cohorts and 15years of studies in human populations that have exploited candidate gene and genome-wide association methods. A small but growing number of gene variants contribute to known longevity mechanisms, but a much larger set have unknown functions. We outline these and other challenges and suggest some possible solutions, including more intense collaboration between research communities that use model organisms and human cohorts. Once hundreds of gene variants have been linked to differences in longevity in mammals, it will become feasible to systematically explore gene-by-environmental interactions, dissect mechanisms with more assurance, and evaluate the roles of epistasis and epigenetics in aging. A deeper understanding of complex networks-genetic, cellular, physiological, and social-should position us well to improve healthspan
Topology optimization of nonlinear periodically microstructured materials for tailored homogenized constitutive properties
A topology optimization method is presented for the design of periodic
microstructured materials with prescribed homogenized nonlinear constitutive
properties over finite strain ranges. The mechanical model assumes linear
elastic isotropic materials, geometric nonlinearity at finite strain, and a
quasi-static response. The optimization problem is solved by a nonlinear
programming method and the sensitivities computed via the adjoint method.
Two-dimensional structures identified using this optimization method are
additively manufactured and their uniaxial tensile strain response compared
with the numerically predicted behavior. The optimization approach herein
enables the design and development of lattice-like materials with prescribed
nonlinear effective properties, for use in myriad potential applications,
ranging from stress wave and vibration mitigation to soft robotics
Dependence of the kinetic energy absorption capacity of bistable mechanical metamaterials on impactor mass and velocity
Using an alternative mechanism to dissipation or scattering, bistable
structures and mechanical metamaterials have shown promise for mitigating the
detrimental effects of impact by reversibly locking energy into strained
material. Herein, we extend prior works on impact absorption via bistable
metamaterials to computationally explore the dependence of kinetic energy
transmission on the velocity and mass of the impactor, with strain rates
exceeding s. We observe a large dependence on both impactor
parameters, ranging from significantly better to worse performance than a
comparative linear material. We then correlate the variability in performance
to solitary wave formation in the system and give analytical estimates of
idealized energy absorption capacity under dynamic loading. In addition, we
find a significant dependence on damping accompanied by a qualitative
difference in solitary wave propagation within the system. The complex dynamics
revealed in this study offer potential future guidance for the application of
bistable metamaterials to applications including human and engineered system
shock and impact protection devices
From waste to health: sustainable exploitation of grape pomace seed extract to manufacture antioxidant, regenerative and prebiotic nanovesicles within circular economy
Pomace seed extract loaded vesicles were prepared as promising technological and green solution to exploit agri-food wastes and by-products, and develop high value-added products for human health. An antioxidant extract rich in bioactive compounds (epicatechins, catechin, gallic acid, quercetin and procynidins) was obtained from the seeds isolated from the pomace of Cannonau red grape cultivar. The extract was incorporated into phospholipid vesicles ad hoc formulated for intestinal delivery, by combining them, for the first time, whit a maltodextrin (Glucidex). Glucidex-transfersomes, glucidex-hyalurosomes and glucidex-hyalutransferomes were prepared, characterized and tested. Glucidex-liposomes were used as reference. All vesicles were small in size (~ 150 nm), homogeneously dispersed and negatively charged. Glucidex-transfersomes and especially glucidex-hyalutransfersomes disclosed an unexpected resistance to acidic pH and high ionic strength, as they maintained their physico-chemical properties (size and size distribution) after dilution at pH 1.2 simulating the harsh gastric conditions. Vesicles were highly biocompatible and able to counteract the oxidative damages induced in Caco-2 cells by using hydrogen peroxide. Moreover, they promoted the formation of Lactobacillus reuteri biofilm acting as prebiotic formulation. Overall results suggest the potential of glucidex-hyalutransfersomes as food supplements for the treatment of intestinal disorders
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