Anxious to see you: Neuroendocrine mechanisms of social vigilance and anxiety during adolescence.

Social vigilance is a behavioral strategy commonly used in adverse or changing social environments. In animals, a combination of avoidance and vigilance allows an individual to evade potentially dangerous confrontations while monitoring the social environment to identify favorable changes. However, prolonged use of this behavioral strategy in humans is associated with increased risk of anxiety disorders, a major burden for human health. Elucidating the mechanisms of social vigilance in animals could provide important clues for new treatment strategies for social anxiety. Importantly, during adolescence the prevalence of social anxiety increases significantly. We hypothesize that many of the actions typically characterized as anxiety behaviors begin to emerge during this time as strategies for navigating more complex social structures. Here, we consider how the social environment and the pubertal transition shape neural circuits that modulate social vigilance, focusing on the bed nucleus of the stria terminalis and prefrontal cortex. The emergence of gonadal hormone secretion during adolescence has important effects on the function and structure of these circuits, and may play a role in the emergence of a notable sex difference in anxiety rates across adolescence. However, the significance of these changes in the context of anxiety is still uncertain, as not enough studies are sufficiently powered to evaluate sex as a biological variable. We conclude that greater integration between human and animal models will aid the development of more effective strategies for treating social anxiety

Backward And Simultaneous Masking Measured In Children With Language-Learning Impairments Who Received Intervention With Fast Forword Or Laureate Learning Systems Software

The developers of a computer-assisted language intervention program called Fast ForWord (FFW) have claimed that their software changes temporal processing abilities as a result of specialized modifications to the acoustic and temporal properties of the speech signal within the program. This pilot study compared changes in auditory temporal processing in children who received FFW training and in children who received training with computer-assisted language intervention programs that were not designed to improve auditory perceptual skills. Four boys with Language-Learning Impairments (LLI) and 3 boys with typical language participated. Two of the boys with LLI received the FFW program, and the other 2 received a bundle of computer-assisted instruction (CAI) programs published by Laureate Language Systems (LLS). The FFW and LLS programs were presented on the same schedule. To assess temporal processing, signal thresholds in backward and simultaneous masking conditions were evaluated just before, during, and immediately after language training. The boys with typically developing language received no training. Children with typical language produced signal thresholds in the backward masking condition that were markedly lower than those in the simultaneous masking condition. This disparity is indicative of normal temporal processing. Conversely, 3 of 4 children with LLI failed to demonstrate a simultaneous-backward difference during baseline. The lack of a difference implies that temporal processing was not normal in these children. The fourth child with LLI had signal thresholds that paralleled those of the children with normal language development. This child also had the mildest form of LLI. Of the 3 children whose temporal processing was abnormal, 2 boys showed decreased signal thresholds in the backward masking condition. However, the improvement was sudden, occurring relatively early in the training sequence, and observed with both treatment programs. The third child with abnormal temporal processing failed to show a change in backward masking at any time during treatment. Over the course of the experiment, signal thresholds for all listeners decreased by similar amounts in both backward and simultaneous masking. Taken together, these results do not support the presence of a program-specific improvement in temporal processing. In addition to the temporal processing deficits revealed by backward masking, group differences in response patterns implicate auditory memory involvement or differences in maintaining attention.Communication Sciences and Disorder

Morning Increase in Onset of Ischemic Stroke

The Time of Onset of Ischemic Stroke Was Determined for 1,167 of 1,273 Patients during the Collection of Data by Four Academic Hospital Centers between June 30, 1983, and June 30, 1986. More Strokes Occurred in Awake Patients from 10:00 Am to Noon Than during Any Other 2-Hour Interval. the Incidence of Stroke Onset Declined Steadily during the Remainder of the Day and Early Evening. the Onset of Stroke is Least Likely to Occur in the Late Evening, Before Midnight. © 1989 American Heart Association, Inc

Pareto optimality solution of the multi-objective photogrammetric resection-intersection problem

Reconstruction of architectural structures from photographs has recently experienced intensive efforts in computer vision research. This is achieved through the solution of nonlinear least squares (NLS) problems to obtain accurate structure and motion estimates. In Photogrammetry, NLS contribute to the determination of the 3-dimensional (3D) terrain models from the images taken from photographs. The traditional NLS approach for solving the resection-intersection problem based on implicit formulation on the one hand suffers from the lack of provision by which the involved variables can be weighted. On the other hand, incorporation of explicit formulation expresses the objectives to be minimized in different forms, thus resulting in different parametric values for the estimated parameters at non-zero residuals. Sometimes, these objectives may conflict in a Pareto sense, namely, a small change in the parameters results in the increase of one objective and a decrease of the other, as is often the case in multi-objective problems. Such is often the case with error-in-all-variable (EIV) models, e.g., in the resection-intersection problem where such change in the parameters could be caused by errors in both image and reference coordinates.This study proposes the Pareto optimal approach as a possible improvement to the solution of the resection-intersection problem, where it provides simultaneous estimation of the coordinates and orientation parameters of the cameras in a two or multistation camera system on the basis of a properly weighted multi-objective function. This objective represents the weighted sum of the square of the direct explicit differences of the measured and computed ground as well as the image coordinates. The effectiveness of the proposed method is demonstrated by two camera calibration problems, where the internal and external orientation parameters are estimated on the basis of the collinearity equations, employing the data of a Manhattan-type test field as well as the data of an outdoor, real case experiment. In addition, an architectural structural reconstruction of the Merton college court in Oxford (UK) via estimation of camera matrices is also presented. Although these two problems are different, where the first case considers the error reduction of the image and spatial coordinates, while the second case considers the precision of the space coordinates, the Pareto optimality can handle both problems in a general and flexible way

Associations between nutrient intake and gastrointestinal symptoms in autism spectrum disorder

Many children and adolescents with autism spectrum disorder (ASD) have significant gastrointestinal (GI) symptoms, but the etiology is not well understood. Studies have shown conflicting evidence on whether there are nutritional deficiencies in the various diets of individuals with ASD. However, little is known about the relationship between dietary intake and GI symptomatology in ASD. The goal of the present study was to assess for potential relationships between GI symptoms and nutrient intake from diet in the same sample of individuals from the previous study, and to determine whether dietary differences might have contributed to our previously observed findings of a relationship between stress responses and GI functioning in ASD