Planeamiento estratégico para el sector turismo de la provincia del Cusco

El presente planeamiento estratégico se ha desarrollado con el objetivo de analizar la problemática actual del sector turismo en la provincia del Cusco, y plantear una situación futura deseada, por medio de una visión y misión, y a partir de ello crear estrategias y proponer las fuentes de recursos necesarios para lograrlo. A través de las diversas estrategias desarrolladas en el presente documento lo que se pretende obtener al llegar el 2028 es el crecimiento de tanto en capacidad como calidad de los productos turísticos que ofrece y puede ofrecer la provincia. Además tener vías de comunicación que permitan el traslado eficiente de los turistas y la generación de empleo resultado del crecimiento del sector. Uno de los problemas más grandes de este sector es la baja inversión que se tiene destinado y es debido a que no es encuentra dentro de la estructura municipal un área que enfoque sus actividades al desarrollo competitivo de esta.The present strategic planning has been developed with the objective of analyzing the current problems of the tourism sector in the province of Cusco, and to propose a desired future situation, through a vision and mission, and from that create strategies and propose the sources of resources needed to achieve it. Through the various strategies developed in this document, what is expected to be achieved by 2028 is the growth in both capacity and quality of the tourism products offered and offered by the province. Also have communication channels that allow the efficient transfer of tourists and the generation of employment resulting from the growth of the sector. One of the biggest problems in this sector is the low investment that has been allocated and it is because it is not within the municipal structure an area that focuses its activities on the competitive development of this.Tesi

Low plasma levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF alpha), and vascular endothelial growth factor (VEGF) in patients with alpha1-antitrypsin deficiency-related fibromyalgia

Abnormalities in blood inflammatory markers have been associated with clinical manifestations and the pathogenesis of the fibromyalgia syndrome (FMS); a relationship between inherited alpha1-antitrypsin deficiency (AATD) and FMS has also been recently raised. In this study, plasma levels of inflammatory markers in FMS patients with and without AATD have been investigated. Blood samples from 138 age-matched females (79 FMS) and 59 general population (GP), with normal MM [n = 82 (59.4%)] and with MS, MZ, SZ, and ZZ AATD genotypes [n = 56 (40.6%)], were analyzed by ELISA for monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF alpha), soluble TNF alpha receptors I and II, interleukin-8, and vascular endothelial growth factor (VEGF). Plasma levels of MCP-1, VEGF, and TNF alpha were significantly lower in FMS and GP subjects with AATD compared with those with normal MM-AAT genotypes. Moreover, plasma levels of MCP-1, VEGF, and TNF alpha were lower in AATD subjects with FMS than in those without FMS (P = 0.000, 0.000, and 0.046, respectively). No statistical differences were found for the other substances measured. Furthermore, a logistic regression model based on plasma MCP-1 cutoff value of a parts per thousand currency sign130 pg/ml allowed us to discriminate between FMS and GP subjects with a sensitivity of about 93% and a specificity of 79%. Low plasma levels of MCP-1, VEGF, and TNF alpha are related to AATD, although more markedly in FMS patients. Thus, hypotheses considering FMS as an inflammatory condition related to high plasma levels of inflammatory biomarkers cannot be supported

FOXE1 Polymorphism Interacts with Dietary Iodine Intake in Differentiated Thyroid Cancer Risk in the Cuban Population

International audienceBackground: The incidence of differentiated thyroid cancer (DTC) is low in Cuba, and the contribution of dietary factors to DTC in this population has not been investigated so far. The aim of this study was to evaluate the relationship between dietary iodine intake and DTC with regard to the interaction with environmental factors or some common single nucleotide polymorphisms (SNPs), based on a case-control study carried out in Cuba.Methods: A total of 203 cases and 212 controls from the general population were interviewed face-to-face using the dietary intake questionnaire and the photo booklet from the E3N cohort. A specific food composition table was constructed for this study. For each parameter studied, the odds ratio (OR) was stratified on age group and sex, and further adjusted for dietary energy, smoking status, ethnic group, level of education, number of pregnancies, and body surface area.Results: The risk of DTC was significantly reduced with increasing consumption of fish (p = 0.04), but no association between total dietary iodine intake and DTC risk was evident (p = 0.7). This lack of significant association was true whatever the age, the smoking status, the dietary selenium intake, and the ethnicity (p > 0.05). DTC risk was positively and strongly associated with the number of copies in the minor allele (A) for SNP rs965513 near FOXE1 among people who consumed less iodine than the median (p = 0.005).Conclusion: Overall, the majority of the studied population had an optimal dietary iodine intake. DTC risk was inversely associated with high fish consumption. Furthermore, DTC risk was positively associated with the number of copies in the minor allele (A) of rs965513 among people who consumed less iodine than the median. Because these findings are based on post-diagnostic measures, studies with pre-diagnostic dietary iodine are needed for confirmation