A review of exposure assessment methods for epidemiological studies of health effects related to industrially contaminated sites

BACKGROUND: this paper is based upon work from COST Action ICSHNet. Health risks related to living close to industrially contaminated sites (ICSs) are a public concern. Toxicology-based risk assessment of single contaminants is the main approach to assess health risks, but epidemiological studies which investigate the relationships between exposure and health directly in the affected population have contributed important evidence. Limitations in exposure assessment have substantially contributed to uncertainty about associations found in epidemiological studies. OBJECTIVES: to examine exposure assessment methods that have been used in epidemiological studies on ICSs and to provide recommendations for improved exposure assessment in epidemiological studies by comparing exposure assessment methods in epidemiological studies and risk assessments. METHODS: after defining the multi-media framework of exposure related to ICSs, we discussed selected multi-media models applied in Europe. We provided an overview of exposure assessment in 54 epidemiological studies from a systematic review of hazardous waste sites; a systematic review of 41 epidemiological studies on incinerators and 52 additional studies on ICSs and health identified for this review. RESULTS: we identified 10 multi-media models used in Europe primarily for risk assessment. Recent models incorporated estimation of internal biomarker levels. Predictions of the models differ particularly for the routes ‘indoor air inhalation’ and ‘vegetable consumption’. Virtually all of the 54 hazardous waste studies used proximity indicators of exposure, based on municipality or zip code of residence (28 studies) or distance to a contaminated site (25 studies). One study used human biomonitoring. In virtually all epidemiological studies, actual land use was ignored. In the 52 additional studies on contaminated sites, proximity indicators were applied in 39 studies, air pollution dispersion modelling in 6 studies, and human biomonitoring in 9 studies. Exposure assessment in epidemiological studies on incinerators included indicators (presence of source in municipality and distance to the incinerator) and air dispersion modelling. Environmental multi-media modelling methods were not applied in any of the three groups of studies. CONCLUSIONS: recommendations for refined exposure assessment in epidemiological studies included the use of more sophisticated exposure metrics instead of simple proximity indicators where feasible, as distance from a source results in misclassification of exposure as it ignores key determinants of environmental fate and transport, source characteristics, land use, and human consumption behaviour. More validation studies using personal exposure or human biomonitoring are needed to assess misclassification of exposure. Exposure assessment should take more advantage of the detailed multi-media exposure assessment procedures developed for risk assessment. The use of indicators can be substantially improved by linking definition of zones of exposure to existing knowledge of extent of dispersion. Studies should incorporate more often land use and individual behaviour

Increasing the Operation Efficiency of Air Conditioning System for Integrated Power Plant on the Base of Its Monitoring

Increasing the Operation Efficiency of Air Conditioning System for Integrated Power Plant on the Base of Its Monitoring / E. Trushliakov, A. Radchenko, S. Forduy, A. Zubarev, A. Hrych // Advances in intelligent systems and computing. – 2020. – Т. 1113 AISC . – P. 351–360Abstract. The efficiency of reciprocating gas engines of integrated energy systems (IES) for combined electricity, heat and refrigeration generation is strictly influenced by their cyclic air temperatures. To evaluate the effect of gas engine cyclic air deep cooling, compared with conventional its cooling, the data on dependence of fuel consumption and power output of gas engine JMS 420 GS-N.L on its inlet air temperature at varying ambient air temperatures at the entrance of the radiator for scavenge air cooling were received. The results of treatment of gas engine efficiency monitoring proved non-effective operation of conventional chilling all the ambient air, coming into the engine room, because of increased air temperature at the inlet of turbocharger (TC), caused by heat influx from surroundings in the engine room. A new method of gas engine inlet air two-stage cooling at increased ambient air temperatures and advanced cyclic air cooling system with absorption lithium-bromide chiller and refrigerant ejector chiller was proposed. With this chilled water from absorption lithiumbromide chiller is used as a coolant in the first high-temperature stage of engine inlet air cooler and boiling refrigerant of ejector chiller in the second lowtemperature stage

Prevalence and morphology of coronary artery ectasia with dual-source CT coronary angiography

To assess the prevalence and morphological characteristics of coronary artery ectasia (CAE) with CT coronary angiography (CTCA) in comparison to conventional catheterangiography (CCA). Dual-source CTCA examinations from 677 consecutive patients (223 women; median age 57 years) were retrospectively evaluated by two blinded observers for the presence of CAE defined as a diameter enlargement >/=1.5 times the diameter of adjacent normal coronary segments. Vessel diameters and contrast attenuation within and proximal to ectatic segments were measured. CCA was used to compare measurements obtained from CTCA with the coronary flow velocity by using the thrombolysis in myocardial infarction (TIMI) frame count. CTCA identified CAE in 20 of 677 (3%) patients. CCA was performed in ten of these patients. CAE diameter measurements with CTCA (10.0 +/- 5.4 mm) correlated significantly (r = 0.92, p < 0.001) with the CCA measurements (8.8 +/- 4.9 mm), but had higher diameters (levels of agreement: -1.0 to 3.4 mm). Contrast attenuation was significantly lower in the ectatic (343 +/- 63 HU) than in the proximal (394 +/- 60 HU) segments (p < 0.01). The attenuation difference significantly correlated with the CAE ratio (r = 0.67, p < 0.01) and the TIMI frame count (r = 0.58, p < 0.05). The prevalence of CAE in a population examined by CTCA is around 3%. Contrast attenuation measurements with CTCA correlate well with the flow alterations assessed with CCA

Tracing Requirements Errors to Problems in the Requirements Engineering Process

A case study of requirements engineering practice is reported. The application, a decision support system for the Greek Ministry of Health, was investigated by studying the process of requirements analysis through to design and implementation. A usability analysis was then conducted on the designed system with the users. Several usability problems were discovered, and interviews uncovered further problems with the system that could be attributed to failure in requirements engineering. Even though requirements were explicitly stated and the system was an evolution from an existing legacy system, functionality was defective and usability was poor. The client&apos;s prime concern for redeveloping the system was to improve usability; unfortunately communications problems in the RE process meant that the developers did not appreciate this. The implications for RE methods and understanding the RE process are discussed. Keywords: case study, requirements engineering, problem analysis, usability. ..