Map Generator for Garmin Devices

Cílem této bakalářské práce je porozumění dat z projektu OpenStreetMap a formáty Garmin *.img souborů. Návrh generování map pomocí nástrojů MkgMap, Splitter, Osmosis a Srtm2Osm a jejich instalování do zařízení Garmin. Poté byla vytvořena aplikace, která nabízí uživatelům jednoduchý způsob, jak si vygenerovat mapu dle svých požadavků. Také nabízí správu souborů OSM, které uživatel používá ke generování. Dále aplikace nabízí možnost instalování vygenerovaných map do zařízení. Výstup této aplikace jsou poté vygenerované soubory map, které je možné nainstalovat do zařízení GarminThe aim of this bachelor thesis is understanding of the OpenStreetMap project data and Garmin *.img file format. Map generation proposal with use of MkgMap, Splitter, Osmosis and Srtm2Osm and installation of those maps to Garmin devices. Desktop application will be developed, that provides simple solution to generate map to its users. The application also provides file manager of OSM data that are used for generating. The generated maps can be installed via the application to Garmin devices. Output of this applications are the generated map files, that can be later installed to Garmin devices.460 - Katedra informatikyvelmi dobř

A computational fluid dynamic investigation of inhomogeneous hydrogen flame acceleration and transition to detonation

Gas explosions in homogeneous reactive mixtures have been widely studied both experimentally and numerically. However, in practice and industrial applications, combustible mixtures are usually inhomogeneous and subject to vertical concentration gradients. Limited studies have been conducted in such context which resulted in limited understanding of the explosion characteristics in such situations. The present numerical investigation aims to study the dynamics of Deflagration to Detonation Transition (DDT) in inhomogeneous hydrogen/air mixtures and examine the effects of obstacle blockage ratio in DDT. VCEFoam, a reactive density-based solver recently assembled by the authors within the frame of OpenFOAM CFD toolbox has been used. VCEFoam uses the Harten–Lax–van Leer–Contact (HLLC) scheme fr the convective fluxes contribution and shock capturing. The solver has been verified by comparing its predictions with the analytical solutions of two classical test cases. For validation, the experimental data of Boeck et al. (1) is used. The experiments were conducted in a rectangular channel the three different blockage ratios and hydrogen concentrations. Comparison is presented between the predicted and measured flame tip velocities. The shaded contours of the predicted temperature and numerical Schlieren (magnitude of density gradient) will be analysed to examine the effects of the blockage ratio on flame acceleration and DDT

Exercise Similarly Facilitates Men and Women’s Selective Attention Task Response Times but Differentially Affects Memory Task Performance

Previous research has found that acute, moderate-intensity physical exercise enhances selective attention and memory and that men and women show differential performance on tasks measuring these skills. Although exercise and participant sex have been examined separately, it remains unknown whether acute, moderate-intensity exercise differentially affects men and women’s selective attention and memory encoding and retrieval. Participants in the present study completed two 10-min sessions of either moderate-intensity exercise comprised of jumping rope alternating with walking in place or an active control protocol comprised of watching wellness videos alternating with walking in place. Each participant completed a selective attention task and a task assessing recognition and object location memory immediately after exercising. Exercise was related to overall faster performance during the selective attention task, with no differences in men and women’s performance. Women showed better recognition memory compared to men. Exercise specifically improved object location memory among men, but only among participants who completed the memory task second. These findings suggest that acute, moderate-intensity exercise differentially affects men and women’s memory, which may be related to complex interactions between exercise, sex hormones, and the neurotrophin BDNF

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma.

Medulloblastoma (MB) is a highly malignant brain tumor that occurs primarily in children. Although surgery, radiation and high-dose chemotherapy have led to increased survival, many MB patients still die from their disease, and patients who survive suffer severe long-term side effects as a consequence of treatment. Thus, more effective and less toxic therapies for MB are critically important. Development of such therapies depends in part on identification of genes that are necessary for growth and survival of tumor cells. Survivin is an inhibitor of apoptosis protein that regulates cell cycle progression and resistance to apoptosis, is frequently expressed in human MB and when expressed at high levels predicts poor clinical outcome. Therefore, we hypothesized that Survivin may have a critical role in growth and survival of MB cells and that targeting it may enhance MB therapy. Here we show that Survivin is overexpressed in tumors from patched (Ptch) mutant mice, a model of Sonic hedgehog (SHH)-driven MB. Genetic deletion of survivin in Ptch mutant tumor cells significantly inhibits proliferation and causes cell cycle arrest. Treatment with small-molecule antagonists of Survivin impairs proliferation and survival of both murine and human MB cells. Finally, Survivin antagonists impede growth of MB cells in vivo. These studies highlight the importance of Survivin in SHH-driven MB, and suggest that it may represent a novel therapeutic target in patients with this disease

Informavores: Active information foraging and human cognition

Just as the body survives by ingesting negative entropy, so the mind survives by ingesting information. In a very general sense, all higher organisms are informavores. The study of active information search is in the midst of a renaissance. Psychological research from diverse areas ranging from developmental psychology This symposium aims to bring together leading experts in this area to discuss how active information foraging can be understood from a diverse set of perspectives within cognitive science. Key themes include how prior knowledge influences search (Markant & Gureckis), how information and reward interact to determine choice (Meder & Nelson), developmental patterns in information seeking behavior (Nelson et al.), information foraging in complex sensemaking tasks (Pirolli), and the allocation of attention during statistical word learning (Yu). While each represents a distinct area of research, all discussants in the symposium share a core approach of applying computational models to understand information search in humans. The symposium should appeal to a broad set of attendees including educators, developmental psychologists, cognitive modelers, and computer scientists. The influence of priors on sequential search decisions - Doug Markant and Todd Gureckis Normative models of information acquisition predict that people's search decisions should be strongly influenced by their prior beliefs, which capture the set of alternative hypotheses they are considering. In the present experiments we tested whether people adjusted their information search behavior in response to sequential changes in the prior. Participants played a search game in which they had to identify the shape and location of multiple hidden targets in a display (similar to the board game Battleship). During the task they were told that the set of possible shapes had changed, and the key question was whether they would adjust their search decisions according to the predictions of a normative model. Manipulations of the prior included changes in the frequency of certain classes of targets as well as the introduction of higherorder constraints (e.g., that all targets would have the same shape). The results showed that an individual's prior could be recovered from their sequences of search decisions, but that there were notable differences in their ability to adjust to certain changes in the hypothesis space, an effect that is not predicted by the normative model. We discuss the implications of these findings for how people generate and represent hypotheses during the course of information foraging. Is people's information search behavior sensitive to different reward structures? -Björn Meder and Jonathan Nelson In situations where humans actively acquire information for classification, information search preferentially maximizes accurac