361 research outputs found
The generation of oxygen radicals during host plant responses to infection
Recent evidence points to significant oxygen radical production by some plant tissues in response to pathogenic challenge. These findings have proved quite controversial, in part because of an inadequate appreciation of the behaviour of oxygen radicals in biological systems. This review critically discusses the evidence to date and outlines several potential roles for oxygen species in host-pathogen interactions. The production of oxygen radicals during plant defence responses is compared to the respiratory burst of mammalian phagocytic cells
One-pot multi-reaction processes: synthesis of natural products and drug-like scaffolds
One-pot multi-reaction processes involving Overman rearrangements, metathesis cyclizations, and Diels–Alder reactions have been developed for the rapid and efficient synthesis of amino-substituted carbocyclic and heterocyclic compounds. This account describes the development and optimization of these processes, as well as their applications in the synthesis of natural products and drug-like scaffolds
Colonization of durum wheat (Triticum turgidum L. var. durum) culms exhibiting premature senescence (dead heads) associated with Fusarium pseudograminearum crown rot
Fusarium crown rot is a significant disease of durum wheat (Triticum turgidum L. var. durum), which exhibits high levels of disease susceptibility. The most extreme symptom of crown rot is a prematurely senescing culm which typically fails to set grain. Individual crown rot-affected durum wheat plants displaying both non-senescent and prematurely senescent culms were harvested to compare visual discoloration, Fusarium pseudograminearum biomass and vascular colonization in culm sections sampled at three different heights above the crown. Field samples of EGA Bellaroi were collected at Wellcamp, Queensland, in 2011, 2012, 2013 and 2014, and of Hyperno at Narrabri, New South Wales, in 2014. Prematurely senescent culms exhibited greater visual discoloration, Fusarium pseudograminearum biomass and vascular colonization than non-senescent culms in each year they were examined. The extent of these differences varied between environments and timing of collection in each year. Vascular colonization initially occurred in xylem vessels and spread into phloem tissues as disease severity increased. The increased presence of hyphae in vascular bundles of prematurely senescing culms provides strong evidence for the hypothesis that restriction of water and nutrient movement in a diseased culm is a key factor in crown rot severity
Post-head-emergence frost in wheat and barley: defining the problem, assessing the damage, and identifying resistance
Radiant frost is a significant production constraint to wheat (Triticum aestivum) and barley (Hordeum vulgare), particularly in regions where spring-habit cereals are grown through winter, maturing in spring. However, damage to winter-habit cereals in reproductive stages is also reported. Crops are particularly susceptible to frost once awns or spikes emerge from the protection of the flag leaf sheath. Post-head-emergence frost (PHEF) is a problem distinct from other cold-mediated production constraints. To date, useful increased PHEF resistance in cereals has not been identified. Given the renewed interest in reproductive frost damage in cereals, it is timely to review the problem. Here we update the extent and impacts of PHEF and document current management options to combat this challenge. We clarify terminology useful for discussing PHEF in relation to chilling and other freezing stresses. We discuss problems characterizing radiant frost, the environmental conditions leading to PHEF damage, and the effects of frost at different growth stages. PHEF resistant cultivars would be highly desirable, to both reduce the incidence of direct frost damage and to allow the timing of crop maturity to be managed to maximize yield potential. A framework of potential adaptation mechanisms is outlined. Clarification of these critical issues will sharpen research focus, improving opportunities to identify genetic sources for improved PHEF resistance
What has preclinical systematic review ever done for us?
Systematic review and meta-analysis are a gift to the modern researcher, delivering a crystallised understanding of the existing research data in any given space. This can include whether candidate drugs are likely to work or not and which are better than others, whether our models of disease have predictive value and how this might be improved and also how these all interact with disease pathophysiology. Grappling with the literature needed for such analyses is becoming increasingly difficult as the number of publications grows. However, narrowing the focus of a review to reduce workload runs the risk of diminishing the generalisability of conclusions drawn from such increasingly specific analyses. Moreover, at the same time as we gain greater insight into our topic, we also discover more about the flaws that undermine much scientific research. Systematic review and meta-analysis have also shown that the quality of much preclinical research is inadequate. Systematic review has helped reveal the extent of selection bias, performance bias, detection bias, attrition bias and low statistical power, raising questions about the validity of many preclinical research studies. This is perhaps the greatest virtue of systematic review and meta-analysis, the knowledge generated ultimately helps shed light on the limitations of existing research practice, and in doing so, helps bring reform and rigour to research across the sciences. In this commentary, we explore the lessons that we have identified through the lens of preclinical systematic review and meta-analysis
Brownian transport in corrugated channels with inertia
The transport of suspended Brownian particles dc-driven along corrugated
narrow channels is numerically investigated in the regime of finite damping. We
show that inertial corrections cannot be neglected as long as the width of the
channel bottlenecks is smaller than an appropriate particle diffusion length,
which depends on the the channel corrugation and the drive intensity. Being
such a diffusion length inversely proportional to the damping constant,
transport through sufficiently narrow obstructions turns out to be always
sensitive to the viscosity of the suspension fluid. The inertia corrections to
the transport quantifiers, mobility and diffusivity, markedly differ for
smoothly and sharply corrugated channels.Comment: 9 pages including figures. arXiv admin note: substantial text overlap
with arXiv:1202.436
The Near-Infrared Number Counts and Luminosity Functions of Local Galaxies
This study presents a wide-field near-infrared (K-band) survey in two fields;
SA 68 and Lynx 2. The survey covers an area of 0.6 deg., complete to
K=16.5. A total of 867 galaxies are detected in this survey of which 175 have
available redshifts. The near-infrared number counts to K=16.5 mag. are
estimated from the complete photometric survey and are found to be in close
agreement with other available studies. The sample is corrected for
incompleteness in redshift space, using selection function in the form of a
Fermi-Dirac distribution. This is then used to estimate the local near-infrared
luminosity function of galaxies. A Schechter fit to the infrared data gives:
M, and Mpc (for H Km/sec/Mpc and q). When
reduced to , this agrees with other available estimates of the local
IRLF. We find a steeper slope for the faint-end of the infrared luminosity
function when compared to previous studies. This is interpreted as due to the
presence of a population of faint but evolved (metal rich) galaxies in the
local Universe. However, it is not from the same population as the faint blue
galaxies found in the optical surveys. The characteristic magnitude
() of the local IRLF indicates that the bright red galaxies ( mag.) have a space density of Mpc and hence,
are not likely to be local objects.Comment: 24 pages, 8 figures, AASTEX 4.0, published in ApJ 492, 45
Physical Conditions in the Seyfert Galaxy NGC 2992
This paper presents long slit spectral maps of the bi-cone shaped extended
narrow line region (ENLR) in the Seyfert galaxy NGC 2992. We investigate the
physical properties of the ENLR via emission line diagnostics, and compare the
observations to shock and photoionization models for the excitation mechanism
of the gas. The line ratios vary as a function of position in the ENLR, and the
loci of the observed points on line ratio diagrams are shown to be most
consistent with shock+precursor model grids. We consider the energetics of a
nuclear ionizing source for the ENLR, and perform the q-test in which the rate
of ionizing photons from the nucleus is inferred from measurements of the
density and ionization parameter. The q-test is shown to be invalid in the case
of NGC 2992 because of the limitations of the [S II]6717/6731 density
diagnostic. The excitation of the gas is shown to be broadly consistent with
the kinematics, with higher [N II]6583/H-alpha present in the more dynamically
active region. We also show that the pressure associated with the X-ray
emitting plasma may provide a large fraction of the pressure required to power
the ENLR via shocks.Comment: 55 pages, 49 figures, ApJ accepted September 9, 1998. Figures 1a-f
are provided in jpeg forma
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