Modulus Stabilization with Bulk Fields

We propose a mechanism for stabilizing the size of the extra dimension in the Randall-Sundrum scenario. The potential for the modulus field that sets the size of the fifth dimension is generated by a bulk scalar with quartic interactions localized on the two 3-branes. The minimum of this potential yields a compactification scale that solves the hierarchy problem without fine tuning of parameters.Comment: 8 pages, LaTeX; minor typo correcte

Anthropic Distribution for Cosmological Constant and Primordial Density Perturbations

The anthropic principle has been proposed as an explanation for the observed value of the cosmological constant. Here we revisit this proposal by allowing for variation between universes in the amplitude of the scale-invariant primordial cosmological density perturbations. We derive a priori probability distributions for this amplitude from toy inflationary models in which the parameter of the inflaton potential is smoothly distributed over possible universes. We find that for such probability distributions, the likelihood that we live in a typical, anthropically-allowed universe is generally quite small.Comment: 12 pages, 2 tables. v3: Replaced to match published version (minor corrections of form

Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer.

BackgroundSipuleucel-T is a US Food and Drug Administration-approved immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Its mechanism of action is not fully understood. This prospective trial evaluated the direct immune effects of systemically administered sipuleucel-T on prostatic cancer tissue in the preoperative setting.MethodsPatients with untreated localized prostate cancer were treated on an open-label Phase II study of sipuleucel-T prior to planned radical prostatectomy (RP). Immune infiltrates in RP specimens (posttreatment) and in paired pretreatment biopsies were evaluated by immunohistochemistry (IHC). Correlations between circulating immune response and IHC were assessed using Spearman rank order.ResultsOf the 42 enrolled patients, 37 were evaluable. Adverse events were primarily transient, mild-to-moderate and infusion related. Patients developed T cell proliferation and interferon-γ responses detectable in the blood following treatment. Furthermore, a greater-than-three-fold increase in infiltrating CD3(+), CD4(+) FOXP3(-), and CD8(+) T cells was observed in the RP tissues compared with the pretreatment biopsy (binomial proportions: all P < .001). This level of T cell infiltration was observed at the tumor interface, and was not seen in a control group consisting of 12 concurrent patients who did not receive any neoadjuvant treatment prior to RP. The majority of infiltrating T cells were PD-1(+) and Ki-67(+), consistent with activated T cells. Importantly, the magnitude of the circulating immune response did not directly correlate with T cell infiltration within the prostate based upon Spearman's rank order correlation.ConclusionsThis study is the first to demonstrate a local immune effect from the administration of sipuleucel-T. Neoadjuvant sipuleucel-T elicits both a systemic antigen-specific T cell response and the recruitment of activated effector T cells into the prostate tumor microenvironment

Photoionization Feedback in Low--Mass Galaxies at High Redshift

The cosmic ultraviolet (UV) ionizing background impacts the formation of dwarf galaxies in the low-redshift universe (z=3) by suppressing gas infall into galactic halos with circular velocities up to v(circ)=75 km/s. Using a one-dimensional, spherically symmetric hydrodynamics code (Thoul & Weinberg 1995), we examine the effect of an ionizing background on low-mass galaxies forming at high redshifts (z>10). We find that the importance of photoionization feedback is greatly reduced, because (1) at high redshift, dwarf-galaxy sized objects can self-shield against the ionizing background, (2) collisional cooling processes at high redshift are more efficient, (3) the amplitude of the ionizing background at high redshift is lower, and (4) the ionizing radiation turns on when the perturbation that will become the dwarf galaxy has already grown to a substantial overdensity. We find that because of these reasons, gas can collect inside halos with circular velocities as low as v(circ)=10 km/s. This result has important implications for the reionization history of the universe.Comment: submitted to ApJ, 10 emulateapj pages with 4 figures include

Implications of Qudit Superselection rules for the Theory of Decoherence-free Subsystems

The use of d-state systems, or qudits, in quantum information processing is discussed. Three-state and higher dimensional quantum systems are known to have very different properties from two-state systems, i.e., qubits. In particular there exist qudit states which are not equivalent under local unitary transformations unless a selection rule is violated. This observation is shown to be an important factor in the theory of decoherence-free, or noiseless, subsystems. Experimentally observable consequences and methods for distinguishing these states are also provided, including the explicit construction of new decoherence-free or noiseless subsystems from qutrits. Implications for simulating quantum systems with quantum systems are also discussed.Comment: 13 pages, 1 figures, Version 2: Typos corrected, references fixed and new ones added, also includes referees suggested changes and a new exampl

Where does Cosmological Perturbation Theory Break Down?

We apply the effective field theory approach to the coupled metric-inflaton system, in order to investigate the impact of higher dimension operators on the spectrum of scalar and tensor perturbations in the short-wavelength regime. In both cases, effective corrections at tree-level become important when the Hubble parameter is of the order of the Planck mass, or when the physical wave number of a cosmological perturbation mode approaches the square of the Planck mass divided by the Hubble constant. Thus, the cut-off length below which conventional cosmological perturbation theory does not apply is likely to be much smaller than the Planck length. This has implications for the observability of "trans-Planckian" effects in the spectrum of primordial perturbations.Comment: 25 pages, uses FeynM

Acromegaly, Mr Punch and caricature.

The origin of Mr Punch from the Italian Pulcinella of the Commedia dell'arte is well known but his feature, large hooked nose, protruding chin, kyphosis and sternal protrusion all in an exaggerated form also suggest the caricature of an acromegalic. This paper looks at the physical characteristics of acromegaly, the origin of Mr Punch and the development of caricature linking them together in the acromegalic caricature that now has a life of its own

The Effective Field Theory of Cosmological Large Scale Structures

Large scale structure surveys will likely become the next leading cosmological probe. In our universe, matter perturbations are large on short distances and small at long scales, i.e. strongly coupled in the UV and weakly coupled in the IR. To make precise analytical predictions on large scales, we develop an effective field theory formulated in terms of an IR effective fluid characterized by several parameters, such as speed of sound and viscosity. These parameters, determined by the UV physics described by the Boltzmann equation, are measured from N-body simulations. We find that the speed of sound of the effective fluid is c_s^2 10^(-6) and that the viscosity contributions are of the same order. The fluid describes all the relevant physics at long scales k and permits a manifestly convergent perturbative expansion in the size of the matter perturbations \delta(k) for all the observables. As an example, we calculate the correction to the power spectrum at order \delta(k)^4. The predictions of the effective field theory are found to be in much better agreement with observation than standard cosmological perturbation theory, already reaching percent precision at this order up to a relatively short scale k \sim 0.24 h/Mpc.Comment: v2: typos corrected, JHEP published versio

Spatial Degrees of Freedom in Everett Quantum Mechanics

Stapp claims that, when spatial degrees of freedom are taken into account, Everett quantum mechanics is ambiguous due to a "core basis problem." To examine an aspect of this claim I generalize the ideal measurement model to include translational degrees of freedom for both the measured system and the measuring apparatus. Analysis of this generalized model using the Everett interpretation in the Heisenberg picture shows that it makes unambiguous predictions for the possible results of measurements and their respective probabilities. The presence of translational degrees of freedom for the measuring apparatus affects the probabilities of measurement outcomes in the same way that a mixed state for the measured system would. Examination of a measurement scenario involving several observers illustrates the consistency of the model with perceived spatial localization of the measuring apparatus.Comment: 34 pp., no figs. Introduction, discussion revised. Material tangential to main point remove

Metastability in Two Dimensions and the Effective Potential

We study analytically and numerically the decay of a metastable phase in (2+1)-dimensional classical scalar field theory coupled to a heat bath, which is equivalent to two-dimensional Euclidean quantum field theory at zero temperature. By a numerical simulation we obtain the nucleation barrier as a function of the parameters of the potential, and compare it to the theoretical prediction from the bounce (critical bubble) calculation. We find the nucleation barrier to be accurately predicted by theory using the bounce configuration obtained from the tree-level (``classical'') effective action. Within the range of parameters probed, we found that using the bounce derived from the one-loop effective action requires an unnaturally large prefactor to match the lattice results. Deviations from the tree-level prediction are seen in the regime where loop corrections would be expected to become important.Comment: 13pp, LaTex with Postscript figs, CLNS 93/1202, DART-HEP-93/0