28 research outputs found
The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe
- Author
- Adams Corey
- Adams David
- Akiri Tarek
- Alion Tyler
- Anderson Kris
- Andreopoulos Costas
- Andrews Mike
- Anghel Ioana
- Anjos João Carlos Costa dos
- Antonello Maddalena
- Arrieta-Diaz Enrique
- Artuso Marina
- Asaadi Jonathan
- Bai Xinhua
- Baibussinov Bagdat
- Baird Michael
- Balantekin Baha
- Baller Bruce
- Baptista Brian
- Barker D'Ann
- Barker Gary
- Barletta William A.
- Barr Giles
- Bartoszek Larry
- Bashyal Amit
- Bass Matt
- Bellini Vincenzo
- Benetti Pietro Angelo
- Berger Bruce E.
- Bergevin Marc
- Berman Eileen
- Berns Hans-Gerd
- Bernstein Adam
- Bernstein Robert
- Bhandari Babu
- Bhatnagar Vipin
- Bhuyan Bipul
- Bian Jianming
- Bishai Mary
- Blake Andrew
- Blaszczyk Flor
- Blaufuss Erik
- Bleakley Bruce
- Blucher Edward
- Blusk Steve
- Bocean Virgil
- Boffelli F.
- Boissevain Jan
- Bolton Timothy
- Bonesini Maurizio
- Boyd Steve
- Brandt Andrew
- Breedon Richard
- Bromberg Carl
- Brown Ralph
- Brunetti Giullia
- Buchanan Norman
- Bugg Bill
- Busenitz Jerome
- Calligarich E.
- Camilleri Leslie
- Carminati Giada
- Carr Rachel
- Castromonte Cesar
- Cavanna Flavio
- Centro Sandro
- Chen Alex
- Chen Hucheng
- Chen Kai
- Cherdack Daniel
- Chi Cheng-Yi
- Childress Sam
- Choudhary Brajesh Chandra
- Christodoulou Georgios
- Christofferson Cabot-Ann
- Church Eric
- Cline David
- Coan Thomas
- Cocco Alfredo
- Coelho Joao
- Coleman Stephen
- Conrad Janet M.
- Convery Mark
- Corey Robert
- Corwin Luke
- Cranshaw Jack
- Cronin-Hennessy Daniel
- Curioni A.
- da Motta Helio
- Davenne Tristan
- Davies Gavin S.
- Dazeley Steven
- de Geronimo Gianluigi
- de Gouvea Andre
- de Jong Jeffrey K.
- De Kaushik
- Demuth David
- Densham Chris
- Diwan Milind
- Djurcic Zelimir
- Dolfini R.
- Dolph Jeffrey
- Drake Gary
- Dye Stephen
- Dyuang Hongue
- Edmunds Daniel
- Elliott Steven
- Elnimr Muhammad
- Eno Sarah
- Enomoto Sanshiro
- Escobar Carlos O.
- Evans Justin
- Falcone A.
- Falk Lisa
- Farbin Amir
- Farnese Christian
- Fava Angela
- Felde John
- Fernandes S.
- Ferroni Fernando
- Feyzi Farshid
- Fields Laura
- Finch Alex
- Fitton Mike
- Fleming Bonnie
- Fowler Jack
- Fox Walt
- Friedland Alex
- Fuess Stu
- Fujikawa Brian
- Gallagher Hugh
- Gandhi Raj
- Garvey Gerald
- Gehman Victor M.
- Gibin Daniele
- Gill Ronald
- Gomes Ricardo A.
- Goodman Maury C.
- Goon Jason
- Graf Nicholas
- Graham Mathew
- Gran Rik
- Grant Christopher
- Grant Nick
- Greenlee Herbert
- Greenler Leland
- Grullon Sean
- Guardincerri Elena
- Guarino Victor
- Guarnaccia Evan
- Guedes Germano
- Guenette Roxanne
- Guglielmi Alberto
- Guzzo Marcelo M.
- Habig Alec T.
- Hackenburg Robert W.
- Hadavand Haleh
- Hahn Alan
- Haigh Martin
- Haines Todd
- Handler Thomas
- Hans Sunej
- Hartnell Jeff
- Harton John
- Hatcher Robert
- Hatzikoutelis Athans
- Hays Steven
- Hazen Eric
- Headley Mike
- Heavey Anne
- Heeger Karsten
- Heise Jaret
- Hellauer Robert
- Hewes Jeremy
- Himmel Alexander
- Hogan Matthew
- Holanda Pedro
- Holin Anna
- Horton-Smith Glenn
- Howell Joe
- Hurh Patrick
- Huston Joey
- Hylen James
- Imlay Richard
- Insler Jonathan
- Introzzi G.
- Isvan Zeynep
- Jackson Chris
- Jacobsen John
- Jaffe David E.
- James Cat
- Jen Chun-Min
- Johnson Marvin
- Johnson Randy
- Johnson Robert
- Johnson Scott
- Johnston William
- Johnstone John
- Jones Ben J. P.
- Jostlein H.
- Junk Thomas
- Kadel Richard
- Kaess Karl
- Karagiorgi Georgia
- Kaspar Jarek
- Katori Teppei
- Kayser Boris
- Kearns Edward
- Keener Paul
- Kemp Ernesto
- Kettell Steve H.
- Kirby Mike
- Klein Joshua
- Koizumi Gordon
- Kopp Sacha
- Kormos Laura
- Kropp William
- Kudryavtsev Vitaly A.
- Kumar Ashok
- Kumar Jason
- Kutter Thomas
- La Zia Franco
- Lande Kenneth
- Lane Charles
- Lang Karol
- Lanni Francesco
- Lanza Richard
- Latorre Tony
- LBNE Collaboration
- Learned John
- Lee David
- Lee Kevin
- Li Qizhong
- Li Shaorui
- Li Yichen
- Li Zepeng
- Libo Jiang
- Linden Steve
- Ling Jiajie
- Link Jonathan
- Littenberg Laurence
- Liu Hu
- Liu Qiuguang
- Liu Tiankuan
- Losecco John
- Louis William
- Lundberg Byron
- Lundin Tracy
- Lundy Jay
- Machado Ana Amelia
- Maesano Cara
- Magill Steve
- Mahler George
- Malon David
- Malys Stephen
- Mammoliti Francesco
- Mandal Samit Kumar
- Mann Anthony
- Mantsch Paul
- Marchionni Alberto
- Marciano William
- Mariani Camillo
- Maricic Jelena
- Marino Alysia
- Marshak Marvin
- Marshall John
- Matsuno Shiegenobu
- Mauger Christopher
- Mavrokoridis Konstantinos
- Mayer Nate
- McCauley Neil
- McCluskey Elaine
- McDonald Kirk
- McFarland Kevin
- McKee David
- McKeown Robert
- McTaggart Robert
- Mehdiyev Rashid
- Mei Dongming
- Menegolli A.
- Meng Guang
- Meng Yixiong
- Mertins David
- Messier Mark
- Metcalf William
- Milincic Radovan
- Miller William
- Mills Geoff
- Mishra Sanjib R.
- Mokhov Nikolai
- Montanari Claudio
- Montanari David
- Moore Craig
- Morfin Jorge
- Morgan Ben
- Morse William
- Moss Zander
- Moura Célio A.
- Mufson Stuart
- Muller David
- Musser Jim
- Naples Donna
- Napolitano Jim
- Newcomer Mitch
- Nichol Ryan
- Nicholls Tim
- Niner Evan
- Norris Barry
- Nowak Jaroslaw
- O'Keeffe Helen
- Oliveira Roberto
- Olson Travis
- Page Brian
- Pakvasa Sandip
- Palamara Ornella
- Paley Jon
- Paolone Vittorio
- Papadimitriou Vaia
- Park Seongtae
- Parsa Zohreh
- Partyka Kinga
- Paulos Bob
- Pavlovic Zarko
- Peeters Simon
- Perch Andy
- Perkin Jon D.
- Petti Roberto
- Petukhov Andre
- Pietropaolo Francesco
- Plunkett Robert
- Polly Chris
- Pordes Stephen
- Potekhin Maxim
- Potenza Renato
- Prakash Arati
- Prokofiev Oleg
- Qian Xin
- Raaf Jennifer L.
- Radeka Veljko
- Rakhno Igor
- Ramachers Yorck
- Rameika Regina
- Ramsey John
- Rappoldi A.
- Raselli G. L.
- Ratoff Peter
- Ravindra Shreyas
- Rebel Brian
- Reichenbacher Juergen
- Reitzner Dianne
- Rescia Sergio
- Richardson Martin
- Rielage Kieth
- Riesselmann Kurt
- Robinson Matt
- Rochester Leon
- Ronquest Michael
- Rosen Marc
- Rossella M.
- Rubbia Carlo
- Rucinski Russ
- Sahijpal Sandeep
- Sahoo Himansu
- Sala Paola
- Salmiera Delia
- Samios Nicholas
- Sanchez Mayly
- Scaramelli Alberto
- Schellman Heidi
- Schmitt Richard
- Schmitz David
- Schneps Jack
- Scholberg Kate
- Segreto Ettore
- Seibert Stanley
- Sexton-Kennedy Liz
- Shaevitz Mike
- Shanahan Peter
- Sharma Rahul
- Shaw Terri
- Simos Nikolaos
- Singh Venktesh
- Sinnis Gus
- Sippach William
- Skwarnicki Tomasz
- Smy Michael
- Sobel Henry
- Soderberg Mitch
- Sondericker John
- Sondheim Walter
- Sousa Alexandre
- Spooner Neil J. C.
- Stancari Michelle
- Stancu Ion
- Stefan Dorota
- Stefanik Andy
- Stewart James
- Stone Sheldon
- Strait James
- Strait Matthew
- Striganov Sergei
- Sullivan Gregory
- Sun Yujing
- Suter Louise
- Svenson Andrew
- Svoboda Robert
- Szczerbinska Barbara
- Szelc Andrzej
- Szydagis Matthew
- Söldner-Rembold Stefan
- Talaga Richard
- Tamsett Matthew
- Tariq Salman
- Tayloe Rex
- Taylor Charles
- Taylor David
- Teymourian Artin
- Themann Harry
- Thiesse Matthew
- Thomas Jenny
- Thompson Lee F.
- Thomson Mark
- Thorn Craig
- Thorpe Matt
- Tian Xinchun
- Tiedt Doug
- Toki Walter
- Tolich Nikolai
- Torti M.
- Toups Matt
- Touramanis Christos
- Tripathi Mani
- Tropin Igor
- Tsai Yun-Tse
- Tull Craig
- Tzanov Martin
- Urheim Jon
- Usman Shawn
- Vagins Mark
- Valdiviesso Gustavo
- Van Berg Rick
- Van de Water Richard
- Van Gemmeren Peter
- Varanini Filippo
- Varner Gary
- Vaziri Kamran
- Velev Gueorgui
- Ventura Sandro
- Vignoli Chiara
- Viren Brett
- Wahl Dan
- Waldron Abby
- Walter Christopher W.
- Wang Hanguo
- Wang Wei
- Warburton Karl
- Warner David
- Wasserman Ryan
- Watson Blake
- Weber Alfons
- Wei Wenzhao
- Wells Douglas
- Wetstein Matthew
- White Andy
- White Hywel
- Whitehead Lisa
- Whittington Denver
- Willhite Joshua
- Wilson Robert J.
- Winslow Lindley
- Wood Kevin
- Worcester Elizabeth
- Worcester Matthew
- Xin Tian
- Yarritu Kevin
- Ye Jingbo
- Yeh Minfang
- Yu Bo
- Yu Jae
- Yuan Tianlu
- Zani A.
- Zeller Geralyn P.
- Zhang Chao
- Zhang Chao
- Zimmerman Eric D.
- Zwaska Robert
- Publication venue
- Publication date
- 28/07/2013
- Field of study
The preponderance of matter over antimatter in the early Universe, the
dynamics of the supernova bursts that produced the heavy elements necessary for
life and whether protons eventually decay --- these mysteries at the forefront
of particle physics and astrophysics are key to understanding the early
evolution of our Universe, its current state and its eventual fate. The
Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed
plan for a world-class experiment dedicated to addressing these questions. LBNE
is conceived around three central components: (1) a new, high-intensity
neutrino source generated from a megawatt-class proton accelerator at Fermi
National Accelerator Laboratory, (2) a near neutrino detector just downstream
of the source, and (3) a massive liquid argon time-projection chamber deployed
as a far detector deep underground at the Sanford Underground Research
Facility. This facility, located at the site of the former Homestake Mine in
Lead, South Dakota, is approximately 1,300 km from the neutrino source at
Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino
charge-parity symmetry violation and mass ordering effects. This ambitious yet
cost-effective design incorporates scalability and flexibility and can
accommodate a variety of upgrades and contributions. With its exceptional
combination of experimental configuration, technical capabilities, and
potential for transformative discoveries, LBNE promises to be a vital facility
for the field of particle physics worldwide, providing physicists from around
the globe with opportunities to collaborate in a twenty to thirty year program
of exciting science. In this document we provide a comprehensive overview of
LBNE's scientific objectives, its place in the landscape of neutrino physics
worldwide, the technologies it will incorporate and the capabilities it will
possess.Comment: Major update of previous version. This is the reference document for
LBNE science program and current status. Chapters 1, 3, and 9 provide a
comprehensive overview of LBNE's scientific objectives, its place in the
landscape of neutrino physics worldwide, the technologies it will incorporate
and the capabilities it will possess. 288 pages, 116 figure
Recommended from our members
Analysis of the African coelacanth genome sheds light on tetrapod evolution
- Author
- Aken Bronwen
- Alföldi Jessica
- Amemiya Chris T.
- Barucca Marco
- Baurain Denis
- Berlin Aaron M.
- Biscotti Maria Assunta
- Blatch Gregory L.
- Braasch Ingo
- Brinkmann Henner
- Buonocore Francesco
- Burmester Thorsten
- Campbell Michael S.
- Canapa Adriana
- Cannon John P.
- Chalopin Domitille
- Christoffels Alan
- De Moro Gianluca
- Di Palma Federica
- Dorrington Rosemary A.
- Edkins Adrienne L.
- Fan Lin
- Fan Shaohua
- Fausto Anna Maria
- Feiner Nathalie
- Forconi Mariko
- Gamieldien Junaid
- Gerdol Marco
- Gnerre Sante
- Gnirke Andreas
- Goldstone Jared V.
- Haerty Wilfried
- Hahn Mark E.
- Hesse Uljana
- Hoffmann Steve
- Jaffe David
- Johnson Jeremy
- Karchner Sibel I.
- Kuraku Shigehiro
- Lander Eric S.
- Lara Marcia
- Lee Alison P.
- Levin Joshua Z.
- Lindblad-Toh Kerstin
- Litman Gary W.
- MacCallum Iain
- Manousaki Tereza
- Mauceli Evan
- Meyer Axel
- Miyake Tsutomu
- Mueller M. Gail
- Nelson David R.
- Nitsche Anne
- Olmo Ettore
- Organ Chris
- Ota Tatsuya
- Pallavicini Alberto
- Panji Sumir
- Philippe Hervé
- Picone Barbara
- Ponting Chris P.
- Postlethwait John H.
- Prohaska Sonja J.
- Przybylski Dariusz
- Ravi Vydianathan
- Ribeiro Filipe J.
- Robinson Mark
- Rohner Nicolas
- Saha Nil Ratan
- Sauka-Spengler Tatjana
- Scapigliati Giuseppe
- Schartl Manfred
- Schneider Igor
- Searle Stephen M. J.
- Sharpe Ted
- Shubin Neil
- Simakov Oleg
- Smith Jeramiah J.
- Stadler Peter F.
- Stegeman John J.
- Sumiyama Kenta
- Tabbaa Diana
- Tabin Clifford J.
- Tafer Hakim
- Turner-Maier Jason
- van Heusden Peter
- Venkatesh Byrappa
- Volff Jean-Nicolas
- White Simon
- Williams Louise
- Yandell Mark
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 10/03/2014
- Field of study
It was a zoological sensation when a living specimen of the coelacanth was first discovered in 1938, as this lineage of lobe-finned fish was thought to have gone extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features . Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain, and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues demonstrate the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
- Author
- Banuett Flora
- Basse Christoph W.
- Birren Bruce W.
- Boyce Kylie J.
- Brefort Thomas
- Butler Jonathan
- Bölker Michael
- Cahill Matt J.
- Calvo Sarah
- Chen Feng
- DeCaprio David
- Deelstra Heine J.
- Farman Mark
- Feldbrügge Michael
- Friedrich Gabi
- Fuchs Uta
- Galagan James
- Gnirke Andreas
- Gold Scott E.
- González-Prieto Juan M.
- Greilinger Doris
- Guzman Plinio
- Güldener Ulrich
- Haase Dirk
- Ho Eric C. H.
- Holloman William K.
- Häuser-Hahn Isolde
- Ibeas Jose I.
- Jaffe David B.
- Kahmann Regine
- Kennell John C.
- Klose Jana
- Klosterman Steven J.
- Koopmann Edda
- Kronstad James W.
- Kämper Jörg
- Ladendorf Oliver
- Li Weixi
- Ma Li-Jun
- Mannhaupt Gertrud
- Margolis Jonathan
- Mauceli Evan W.
- McCann Michael
- Mendoza-Mendoza Artemio
- Meng Shaowu
- Mewes Hans-Werner
- Molina Lazaro
- Müller Olaf
- Münch Karin
- Münsterkötter Martin
- Nusbaum Chad
- Oesterheld Matthias
- Ortiz-Castellanos Lucila
- Perlin Michael H.
- Platt Darren
- Pérez-Martín José
- Reynaga-Peña Cristina G.
- Ruiz-Herrera José
- Rössel Nicole
- Sanchez-Alonso Patricia
- Sandrock Björn
- Saville Barry J.
- Scherer Mario
- Schirawski Jan
- Schlüter Thomas
- Schreier Peter H.
- Sentandreu Rafael
- Snetselaar Karen
- Stajich Jason E.
- Steinberg Gero
- Swimmer Candace
- Vaupel Martin
- Vincon Volker
- Voss Hartmut
- Vraneš Miroslav
- Vries Ronald de
- Vysotskaia Valentina
- Wade Claire M.
- Wösten Han A. B.
- Young Sarah
- Publication venue
- Nature Publishing Group
- Publication date
- 24/11/2023
- Field of study
Ustilago maydis is a ubiquitous pathogen of maize and a well-established model organism for the study of plant-microbe interactions. This basidiomycete fungus does not use aggressive virulence strategies to kill its host. U. maydis belongs to the group of biotrophic parasites (the smuts) that depend on living tissue for proliferation and development. Here we report the genome sequence for a member of this economically important group of biotrophic fungi. The 20.5-million-base U. maydis genome assembly contains 6,902 predicted protein-encoding genes and lacks pathogenicity signatures found in the genomes of aggressive pathogenic fungi, for example a battery of cell-wall-degrading enzymes. However, we detected unexpected genomic features responsible for the pathogenicity of this organism. Specifically, we found 12 clusters of genes encoding small secreted proteins with unknown function. A significant fraction of these genes exists in small gene families. Expression analysis showed that most of the genes contained in these clusters are regulated together and induced in infected tissue. Deletion of individual clusters altered the virulence of U. maydis in five cases, ranging from a complete lack of symptoms to hypervirulence. Despite years of research into the mechanism of pathogenicity in U. maydis, no 'true' virulence factors had been previously identified. Thus, the discovery of the secreted protein gene clusters and the functional demonstration of their decisive role in the infection process illuminate previously unknown mechanisms of pathogenicity operating in biotrophic fungi. Genomic analysis is, similarly, likely to open up new avenues for the discovery of virulence determinants in other pathogens. ©2006 Nature Publishing Group.J.K., M. B. and R.K. thank G. Sawers and U. Kämper for critical reading of the manuscript. The genome sequencing of Ustilago maydis strain 521 is part of the fungal genome initiative and was funded by National Human Genome Research Institute (USA) and BayerCropScience AG (Germany). F.B. was supported by a grant from the National Institutes of Health (USA). J.K. and R.K. thank the German Ministry of Education and Science (BMBF) for financing the DNA array setup and the Max Planck Society for their support of the manual genome annotation. F.B. was supported by a grant from the National Institutes of Health, B.J.S. was supported by the Natural Sciences and Engineering Research Council of Canada and the Canada Foundation for Innovation, J.W.K. received funding from the Natural Sciences and Engineering Research Council of Canada, J.R.-H. received funding from CONACYT, México, A.M.-M. was supported by a fellowship from the Humboldt Foundation, and L.M. was supported by an EU grant. Author Contributions All authors were involved in planning and executing the genome sequencing project. B.W.B., J.G., L.-J.M., E.W.M., D.D., C.M.W., J.B., S.Y., D.B.J., S.C., C.N., E.K., G.F., P.H.S., I.H.-H., M. Vaupel, H.V., T.S., J.M., D.P., C.S., A.G., F.C. and V. Vysotskaia contributed to the three independent sequencing projects; M.M., G.M., U.G., D.H., M.O. and H.-W.M. were responsible for gene model refinement, database design and database maintenance; G.M., J. Kämper, R.K., G.S., M. Feldbrügge, J.S., C.W.B., U.F., M.B., B.S., B.J.S., M.J.C., E.C.H.H., S.M., F.B., J.W.K., K.J.B., J. Klose, S.E.G., S.J.K., M.H.P., H.A.B.W., R.deV., H.J.D., J.R.-H., C.G.R.-P., L.O.-C., M.McC., K.S., J.P.-M., J.I.I., W.H., P.G., P.S.-A., M. Farman, J.E.S., R.S., J.M.G.-P., J.C.K., W.L. and D.H. were involved in functional annotation and interpretation; T.B., O.M., L.M., A.M.-M., D.G., K.M., N.R., V. Vincon, M. VraneŠ, M.S. and O.L. performed experiments. J. Kämper, R.K. and M.B. wrote and edited the paper with input from L.-J.M., J.G., F.B., J.W.K., B.J.S. and S.E.G. Individual contributions of authors can be found as Supplementary Notes
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat Rüdeger
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Étienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
- Bouchet Patrice
- Bouwman Jeroen
- Bower Gary
- Bowers Ariel S.
- Bowers Charles W.
- Boyce Leslye A.
- Boyer Christine T.
- Boyer Martha L.
- Boyer Michael
- Boyer Robert
- Bradley Larry D.
- Brady Gregory R.
- Brandl Bernhard R.
- Brannen Judith L.
- Breda David
- Bremmer Harold G.
- Brennan David
- Bresnahan Pamela A.
- Bright Stacey N.
- Broiles Brian J.
- Bromenschenkel Asa
- Brooks Brian H.
- Brooks Keira J.
- Brown Bob
- Brown Bruce
- Brown Thomas M.
- Bruce Barry W.
- Bryson Jonathan G.
- Bujanda Edwin D.
- Bullock Blake M.
- Bunker A. J.
- Bureo Rafael
- Burt Irving J.
- Bush James Aaron
- Bushouse Howard A.
- Bussman Marie C.
- Böker Torsten
- Cabaud Olivier
- Cale Steven
- Calhoon Charles D.
- Calvani Humberto
- Canipe Alicia M.
- Caputo Francis M.
- Cara Mihai
- Carey Larkin
- Case Michael Eli
- Cesari Thaddeus
- Cetorelli Lee D.
- Chance Don R.
- Chandler Lynn
- Chaney Dave
- Chapman George N.
- Charlot S.
- Chayer Pierre
- Cheezum Jeffrey I.
- Chen Bin
- Chen Christine H.
- Cherinka Brian
- Chichester Sarah C.
- Chilton Zachary S.
- Chittiraibalan Dharini
- Clampin Mark
- Clark Charles R.
- Clark Kerry W.
- Clark Stephanie M.
- Claybrooks Edward E.
- Cleveland Keith A.
- Cohen Andrew L.
- Cohen Lester M.
- Coleman Benee L.
- Colina Luis
- Colón Knicole D.
- Comber Brian J.
- Comeau Thomas M.
- Comer Thomas
- Connolly Dennis C.
- Conroy Kyle E.
- Contos Adam R.
- Contreras James
- Cook Neil J.
- Cooper James L.
- Cooper Rachel Aviva
- Correia Michael F.
- Correnti Matteo
- Cossou Christophe
- Costanza Brian F.
- Costas Maria Begoña Vila
- Coulais Alain
- Cox Colin R.
- Coyle Ray T.
- Cracraft Misty M.
- Crew Keith A.
- Curtis Gary J.
- Cusveller Bianca
- Dailey Christopher T.
- Darveau-Bernier Antoine
- Daugeron Frédéric
- Davidson Greg S.
- Davies James E.
- Davis Katherine Anne
- Davis Michael S.
- Day Ratna
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- Waddy Darryl J.
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- Walker Jr. Frederick E.
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- Warfield Christine K.
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- Whitehouse Paul
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- Wilson Debra
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- Wislowski Emily Christine
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- Wondel Amancio
- Woo Cindy
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- Wu Carl
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- Young Gary
- Yu Gene
- Yu Susan
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- Zonak Stephanie
- Zondag Elisabeth
- Álvarez-Márquez Javier
- Östlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
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- Brandriff Brigitte F.
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- Brettin Thomas
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- Curran Adam
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- Daum Christopher
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- Harbes Brandy A.
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- Heyen Joshua
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- Hildebrand Carl E.
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- Imbro Paula
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- Iwakawa Shinobu
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- Jackson Terri
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- Jaeger Sara
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- Jia Jia
- Jia Jia
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- Kettleborough Ross
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- Khan Ziad Mohid
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- Kremitzki Colin
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- Ludeman Thom
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- Macht Madison
- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
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- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Green Clubs and Voluntary Governance: ISO 14001 and Firms' Regulatory Compliance
- Author
- Acemoglu Daron
- Ayres Ian
- Brehm John
- Buchanan James M.
- Cameron A. Colin
- Carpenter Daniel P.
- Carpenter Daniel P.
- Center For Energy And Environmental Management
- Center for Energy and Environmental Management
- Cornes Richard
- Crowe Michael.
- Fiorino Daniel J.
- Fiorino Daniel. J.
- General Accounting Office (GAO)
- Gerber Brian
- Gormley William T.
- Greene William H.
- Gunningham Neil A.
- Hale Rhea
- Haufler Virginia.
- Hoffman A.J.
- Housman V.A.
- Jaffe Adam
- King Andrew
- Kolk Ans.
- Kollman Kelly
- Long J. Scott.
- Lubell Mark
- Prakash A.
- Prakash A.
- Ringquist Evan.
- Scholz John T.
- Scholz John T.
- Scholz John. T.
- Steinzor Rena. I.
- Walley Noah
- Williamson Oliver.
- Winter Soren
- Wood B. Dan
- Wood B. Dan.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions
- Author
- Abyzov Alexej
- Adolfsson Rolf
- Agartz Ingrid
- Akbarian Schahram
- Albus Margot
- Alexander Madeline
- Amero Aitor Serres
- Amin Farooq
- Andreassen Ole A.
- Antaki Danny
- Antaki Danny
- Atkins Joshua
- Averbuj Dan
- Bacanu Silviu A.
- Bae Taejeong
- Ball Laurel
- Belliveau Richard A.
- Bergen Sarah E.
- Bertalan Marcelo
- Bevilacqua Elizabeth
- Bigdeli Tim B.
- Bizzotto Sara
- Black Donald W.
- Blackwood Douglas H.R.
- Bohrson Craig
- Borges-Monroy Rebeca
- Bramon Elvira
- Brandler William M.
- Brennand Kristen J.
- Breuss Martin
- Bruggeman Richard
- Buccola Nancy G.
- Buckner Randy L.
- Bulik-Sullivan Brendan
- Burris S.J.
- Buxbaum Joseph D.
- Byerley William
- Cahn Wiepke
- Cai Guiqing
- Cairns Murray J.
- Campion Dominique
- Cantor Rita M.
- Carr Vaughan J.
- Carrera Noa
- Catts Stanley V.
- Chambert Kimberley D.
- Cheng Wei
- Cherskov Adriana
- Chess Andrew
- Cho Sean
- Chu Chong
- Chung Changuk
- Cichon Sven
- Cloninger C. Robert
- Cohen David
- Collier David A.
- Cormican Paul
- Cortes-Ciriano Isidro
- Corvin Aiden
- Coulter Michael
- Courchesne Eric
- Craddock Nick
- Crespo-Facorro Benedicto
- Crowley James J.
- Curtis David
- D'Gama Alissa
- Daly Mark J.
- Darvasi Ariel
- Davidson Michael
- Davis Kenneth L.
- de Haan Lieuwe
- Degenhardt Franziska
- Del Favero Jurgen
- DeLisi Lynn E.
- Dias Caroline
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Domenici Enrico
- Donohoe Gary
- Dou Yanmei
- Drapeau Elodie
- Duan Jubao
- Dudbridge Frank
- Eichhammer Peter
- Emery Sarah B.
- Eriksson Johan
- Erwin Jennifer
- Escott-Price Valentina
- Esko Tõnu
- Essioux Laurent
- Fanous Ayman H.
- Farh Kai-How
- Farrell Martilias S.
- Fasching Liana
- Flaherty Erin
- Flasch Diane A.
- Forstner Andreas J.
- Frank Josef
- Franke Lude
- Freedman Robert
- Freimer Nelson B.
- Friedman Joseph I
- Frisbie Trenton J.
- Fromer Menachem
- Fuentes Fajarado Karin V.
- Gage Fred
- Gage Fred H.
- Galor Alon
- Ganz Javier
- Gejman Pablo V.
- Genovese Giulio
- Georgieva Lyudmila
- Gershon Elliot S.
- Giegling Ina
- Gilgenast Thomas G.
- Gill Michael
- Giusti-Rodríguez Paola
- Gleeson Joseph
- Godard Stephanie
- Goldstein Jacqueline I.
- Gratten Jacob
- Greer Douglas S.
- Gujral Madhusudan
- Gulhan Doga
- Gurling Hugh
- Hamshere Marian L.
- Hansen Mark
- Hansen Thomas
- Haroutunian Vahram
- Hartmann Annette M.
- Henskens Frans A.
- Herms Stefan
- Hill Robert
- Hirschhorn Joel N.
- Hoffmann Per
- Hofman Andrea
- Holmans Peter A.
- Howrigan Daniel P
- Huang August Yue
- Huang Hailiang
- Hultman Christina M.
- Ikeda Masashi
- Iwata Nakao
- Jablensky Assen V.
- Jaffe Andrew
- Jang Yeongjun
- Joa Inge
- Jones Attila
- Jourdon Alexandre
- Juan David
- Jönsson Erik G.
- Kahn René S
- Kalaydjieva Luba
- Kamath Tushar
- Karjalainen Juha
- Kavanagh David
- Keller Matthew C.
- Kelly Brian J.
- Kendler Kenneth S.
- Kennedy James L.
- Khoshkhoo Sattar
- Kidd Jeffrey M.
- Kim Sonia
- Kim Yunjung
- Kirov George
- Klein Marieke
- Knight Jo
- Knowles James A.
- Konte Bettina
- Kopera Huira C.
- Kwan Kenneth Y.
- Kwon Minseok
- Kähler Anna K.
- Langmead Ben
- Laurent Claudine
- Lee Eunjung A.
- Lee Phil
- Lee S. Hong
- Legge Sophie E.
- Lerer Bernard
- Levinson Douglas F.
- Levy Deborah L.
- Li Qingqin S.
- Liang Kung-Yee
- Lieberman Jeffrey
- Linker Sara
- Lobon Irene
- Lodato Michael
- Loh Po-Ru
- Loughland Carmel M.
- Luquette Joe
- Lönnqvist Jouko
- Macosko Evan Z.
- Magnusson Patrik K.E.
- Maher Brion S.
- Maier Wolfgang
- Maile Michelle S.
- Malhotra Dheeraj
- Mallet Jacques
- Marques-Bonet Tomas
- Marshall Christian R.
- Mathern Gary
- Mattheisen Manuel
- Mattingsdal Morten
- Maury Eduardo A.
- McCarley Robert W.
- McCarroll Steven A.
- McConnell Michael
- McDonald Colm
- McIntosh Andrew M.
- McQuillin Andrew
- Meier Sandra
- Meijer Carin J.
- Melle Ingrid
- Merico Daniele
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Michie Patricia T.
- Milani Lili
- Milanova Vihra
- Miller Michael
- Mills Ryan E.
- Mokrab Younes
- Moldovan John B.
- Moran Jennifer L.
- Moran John V.
- Morris Derek W.
- Moruno Manuel Solis
- Mowry Bryan J.
- Murphy Kieran C.
- Murray Robin M.
- Myin-Germeys Inez
- Müller-Myhsok Bertram
- Narurkar Rujuta
- Neale Benjamin M.
- Nenadic Igor
- Nertney Deborah A.
- Nestadt Gerald
- Nicodemus Kristin K.
- Nisenbaum Laura
- Nordin Annelie
- Nöthen Markus M.
- O'Callaghan Eadbhard
- O'Donovan Michael
- O'Dushlaine Colm
- O'Neill F. Anthony
- Oh Sang-Yun
- Olincy Ann
- Olsen Line
- Ophoff Roel A.
- Owen Michael J.
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N.
- Paquola Apua
- Park Peter J.
- Parkhomenko Elena
- Pato Carlos N.
- Pato Michele T.
- Pattni Reenal
- Paunio Tiina
- Perez Raquel Garcia
- Perkins Diana O.
- Pers Tune H.
- Petryshen Tracey L.
- Phillips-Cremins Jennifer E.
- Pietiläinen Olli
- Pimm Jonathan
- Pinto Dalila
- Pochareddy Sirisha
- Pocklington Andrew J.
- Posthuma Danielle
- Povolotskaya Inna
- Powell John
- Price Alkes
- Pulver Ann E.
- Purcell Shaun M.
- Quested Digby
- Rajarajan Prashanth
- Rasmussen Henrik B.
- Reed Patrick
- Reichenberg Abraham
- Reimers Mark A.
- Richards Alexander L.
- Rietschel Marcella
- Riley Brien P.
- Ripke Stephan
- Rodin Rachel
- Roffman Joshua L.
- Rosenbluh Chaggai
- Roussos Panos
- Roy Subhojit
- Ruderfer Douglas M.
- Rujescu Dan
- Salomaa Veikko
- Sanders Alan R.
- Savitz Adam
- Schall Ulrich
- Scherer Stephen W.
- Schulze Thomas G.
- Schwab Sibylle G.
- Scolnick Edward M.
- Scott Rodney J.
- Scuderi Soraya
- Sebat Jonathan
- Seidman Larry J.
- Sestan Nenad
- Shanta Omar
- Sherman Maxwell A.
- Shetty Aniket
- Shi Jianxin
- Shin Jooheon
- Silverman Jeremy M.
- Sklar Pamela
- Smoller Jordan W.
- Smoller Jordan W.
- Soriano Eduardo
- Spencer Chris C.A.
- St. Clair David
- Stahl Eli A.
- Straub Richard
- Strengman Eric
- Strohmaier Jana
- Stroup T. Scott
- Sullivan Patrick
- Sun Chen
- Suvisaari Jaana
- Svrakic Dragan M
- Szatkiewicz Jin P.
- Söderman Erik
- Thirumalai Srinivas
- Thiruvahindrapuram Bhooma
- Thorpe Jeremy
- Tooney Paul A.
- Urban Alexander
- Vaccarino Flora M.
- Van Os Jim
- Veijola Juha
- Visscher Peter M.
- Viswanadham Vinay
- Waddington John
- Walsh Christopher A.
- Walsh Dermot
- Walters James T.R.
- Wang Meiyan
- Wang Yifan
- Wang Zhouzhi
- Webb Bradley T.
- Weinberger Daniel
- Weiser Mark
- Werge Thomas
- Wildenauer Dieter B.
- Williams Nigel M.
- Williams Stephanie
- Witt Stephanie H.
- Wolen Aaron R.
- Wormley Brandon K.
- Wray Naomi R.
- Wu Jing Qin
- Wu Wenting
- Yang Xiaoxu
- Zai Clement C.
- Zhao Xuefang
- Zhou Bo
- Zhou Weichen
- Zhou Zinan
- Zhu Xiaowei
- Publication venue
- Cell Press
- Publication date
- 09/08/2023
- Field of study
While germline copy-number variants (CNVs) contribute to schizophrenia (SCZ) risk, the contribution of somatic CNVs (sCNVs)—present in some but not all cells—remains unknown. We identified sCNVs using blood-derived genotype arrays from 12,834 SCZ cases and 11,648 controls, filtering sCNVs at loci recurrently mutated in clonal blood disorders. Likely early-developmental sCNVs were more common in cases (0.91%) than controls (0.51%, p = 2.68e−4), with recurrent somatic deletions of exons 1–5 of the NRXN1 gene in five SCZ cases. Hi-C maps revealed ectopic, allele-specific loops forming between a potential cryptic promoter and non-coding cis-regulatory elements upon 5′ deletions in NRXN1. We also observed recurrent intragenic deletions of ABCB11, encoding a transporter implicated in anti-psychotic response, in five treatment-resistant SCZ cases and showed that ABCB11 is specifically enriched in neurons forming mesocortical and mesolimbic dopaminergic projections. Our results indicate potential roles of sCNVs in SCZ risk
Malingering Uncommon Psychiatric Symptoms Among Defendants Charged Under California's “Three Strikes and You're Out” Law
- Author
- Publication venue
- 'ASTM International'
- Publication date
- Field of study