New possibilities for QCD at finite density

I review the growing theoretical indications that at high densities color SU(3) gauge symmetry is spontaneously broken by the formation of a quark pair condensate. This leads to a rich phase structure for QCD as a function of temperature and chemical potential. I also discuss the prospects for lattice QCD calculations at finite density, including the Glasgow algorithm and imaginary chemical potential.Comment: LATTICE98(hightemp), 6 pages, LaTe

ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid.

5-Lipoxygenase (5-LOX) reacts with arachidonic acid (AA) to first generate 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid [5(S)-HpETE] and then an epoxide from 5(S)-HpETE to form leukotriene A4, from a single polyunsaturated fatty acid. This work investigates the kinetic mechanism of these two processes and the role of ATP in their activation. Specifically, it was determined that epoxidation of 5(S)-HpETE (dehydration of the hydroperoxide) has a rate of substrate capture (Vmax/Km) significantly lower than that of AA hydroperoxidation (oxidation of AA to form the hydroperoxide); however, hyperbolic kinetic parameters for ATP activation indicate a similar activation for AA and 5(S)-HpETE. Solvent isotope effect results for both hydroperoxidation and epoxidation indicate that a specific step in its molecular mechanism is changed, possibly because of a lowering of the dependence of the rate-limiting step on hydrogen atom abstraction and an increase in the dependency on hydrogen bond rearrangement. Therefore, changes in ATP concentration in the cell could affect the production of 5-LOX products, such as leukotrienes and lipoxins, and thus have wide implications for the regulation of cellular inflammation

MAP kinase phosphatase 2 deficient mice develop attenuated experimental autoimmune encephalomyelitis through regulating dendritic cells and T cells

Mitogen-activated protein kinase phosphatases (MKPs) play key roles in inflammation and immune mediated diseases. Here we investigated the mechanisms by which MKP-2 modulates central nervous system (CNS) inflammation in experimental autoimmune encephalomyelitis (EAE). Our results show that MKP-2 mRNA levels in the spinal cord and lymphoid organs of EAE mice were increased compared with naive controls, indicating an important role for MKP-2 in EAE development. Indeed, MKP-2-/- mice developed reduced EAE severity, associated with diminished CNS immune cell infiltration, decreased proinflammatory cytokine production and reduced frequency of CD4+ and CD8+ T cells in spleens and lymph nodes. In addition, MKP-2-/- CD11c+ dendritic cells (DCs) had reduced expression of MHC-II and CD40 compared with MKP-2+/+ mice. Subsequent experiments revealed that CD4+ T cells from naïve MKP-2-/- mice had decreased cell proliferation and IL-2 and IL-17 production relative to wild type controls. Furthermore, co-culture experiments showed that bone marrow derived DCs of MKP-2-/-mice had impaired capability in antigen presentation and T cell activation. While MKP-2 also modulates macrophage activation, our study suggests that MKP-2 is essential to the pathogenic response of EAE, and it acts mainly via regulating the important antigen presenting DC function and T cell activation

Situating the Georgia Performance Standards in the Social Studies Debate: An Improvement for Social Studies Classrooms or Continuing the Whitewash

After approximately two decades of using the Quality Core Curriculum, in 2005 the State of Georgia began the process of implementing the new Georgia Performance Standard. In this article the authors examine the strengths and weaknesses of this new curriculum, along with the proposed model of implementation. In this examination, the authors will attempt to situate both the standards and their implementation within the current political struggle over curriculum in the United States

Imaginary chemical potential and finite fermion density on the lattice

Standard lattice fermion algorithms run into the well-known sign problem at real chemical potential. In this paper we investigate the possibility of using imaginary chemical potential, and argue that it has advantages over other methods, particularly for probing the physics at finite temperature as well as density. As a feasibility study, we present numerical results for the partition function of the two-dimensional Hubbard model with imaginary chemical potential. We also note that systems with a net imbalance of isospin may be simulated using a real chemical potential that couples to I_3 without suffering from the sign problem.Comment: 9 pages, LaTe

The Dynamic Duo: Collaboration Between Writing Centers and Academic Libraries

As academic libraries move toward the model of the information commons – a place where users can expect support in finding, interpreting, creating, and communicating information – it increasingly makes sense for university writing centers to have a more prominent presence within the library. But collaboration between libraries and writing centers promises more than just “one-stop shopping” for students as they write their papers. Working together can also provide both libraries and writing centers new opportunities to promote their services to students and faculty. In order for such collaborations to move forward, libraries and writing centers need to acknowledge the similarities and differences in the work they do with students, specifically in such areas of concern as: student research, plagiarism and citation issues especially with regard to international students or English Language Learners. During our session, participants will have the opportunity to hear about the panel’s experiences, learn about the many connections between writing centers and libraries, discover ways that libraries can collaborate with writing centers and address the pitfalls and considerations associated with these partnerships

Schism or Communion? A Discussion of the Morality of Online Learning through a Christian/Catholic Lens

While massive open online courses (MOOCs) garnered plenty of attention at the beginning of the decade, initial findings about their value have been disappointing. In particular, only a narrow range of participants appear to be successful in completing and passing these unmonitored courses: white, educated, affluent males. One prominent Catholic scholar, Jonathan Malesic, went as far as saying that the very nature of MOOCs does not align with Catholic teachings of learning through social interaction, adapting to the needs of the learner, and teaching (i.e., successfully) the masses. Further, by extension, he applied these criticisms to online learning in general. This article examines these criticisms, describes how these problems are present in K-12 online learning, and gives examples of how these issues are mitigated. The article concludes with ideas for using the online learning medium to promote Catholic and Christian values

Urban Design and Quality of Life

This chapter deals with those aspects of the design of cities that have been shown to affect quality of life. Whilst direct causal relationships between physical space and well-being are often difficult to establish, physical space certainly does play a significant part in shaping the way we engage with it, informing the individual and collective sense of attachment to our own environment; this will become increasingly important, with the urbanization process predicted to grow, a significant part of which in conditions of informality. The aim of this chapter is to gather relevant and recent research that highlights advances in the study of the reciprocal effect between urban form and urban life and use this to compile an agenda for future thinking, research and practice in the field of socially sustainable urban design. The thrust of this agenda is centered on the concept of control. Since urbanization is an ongoing phenomenon and life in cities is now the norm for the vast majority of people, the traditional role of design needs to be reconsidered to give way to more collaborative and flexible forms of conceptualization, creation, occupation and management of space. This is important in order to relieve pressure on land and institutions, and instill an overall proactive and reciprocal attitude towards space itself, and space as a form of collective and social life. The chapter will highlight that urban quality of life rests on four core themes of: material well-being; emotional and personal development; interpersonal relationships; and physical well-being. These themes provide an organizational framework for exploration of how they are manifest at the metropolitan, neighbourhood and pedestrian levels of scale

Inverted orbital polarization in strained correlated oxide films

Manipulating the orbital occupation of valence electrons via epitaxial strain in an effort to induce new functional properties requires considerations of how changes in the local bonding environment affect the band structure at the Fermi level. Using synchrotron radiation to measure the x-ray linear dichroism of epitaxially strained films of the correlated oxide CaFeO3, we demonstrate that the orbital polarization of the Fe valence electrons is opposite from conventional understanding. Although the energetic ordering of the Fe 3d orbitals is confirmed by multiplet ligand field theory analysis to be consistent with previously reported strain-induced behavior, we find that the nominally higher energy orbital is more populated than the lower. We ascribe this inverted orbital polarization to an anisotropic bandwidth response to strain in a compound with nearly filled bands. These findings provide an important counterexample to the traditional understanding of strain-induced orbital polarization and reveal a new method to engineer otherwise unachievable orbital occupations in correlated oxides