Secondary dyslipidaemia

No Abstract

The differentiation of pleural effusions

CITATION: Martiz, F. J. 1982. The differentiation of pleural effusions. South African Medical Journal, 62:553-556.The original publication is available at http://www.samj.org.zaThe causes and pathophysiology of pleural effusions are briefly discussed. A method for staining pleural effusions is described and the importance of side-room microscopy in the evaluation of pleural fluids is emphasized. The value of various investigations in the differentiation of pleural effusions is reviewed.Publisher’s versio

A statistical exploration of interval-deficient wind speed data for application to wind power assessments

Gathering quality wind speed data can be time-consuming and expensive. The present study established whether interval-deficient wind speed data could be rendered useful for wind power assessments. The effect of interval deficiency on the quality of the wind speed data was investigated by studying the behaviour of the Weibull scale and shape factors as the interval size between wind speed measurements increased. Five wind speed data sets obtained from the Southern African Universities Radiometric Network (Sauran) were analysed, based on a proposed procedure to find the true Weibull parameters from an interval-deficient wind speed data set. It was found that the relative errors in the Weibull parameters were, on average, less than 1%, compared with the Weibull parameters computed from a wind speed data set that complies with the IEC 61400-12-1:2005(E) standard. This finding may contribute to time and cost reduction in wind power assessments. It may also promote the application of statistical methods in the renewable energy sector

A note on exact solutions of the logistic map

CITATION:Maritz MF. A note on exact solutions of the logistic map. Chaos. 2020 Mar;30(3):033136. doi: 10.1063/1.5125097The logistic map, whose iterations lead to period doubling and chaos as the control parameter, is increased and has three cases of the control parameter where exact solutions are known. In this paper, we show that general solutions also exist for other values of the control parameter. These solutions employ a special function, not expressible in terms of known analytical functions. A method of calculating this function numerically is proposed, and some graphs of this function are given, and its properties are discussed. The logistic map is often studied as a model of the period doubling route to chaos as its control parameter is increased. For three particular values of the control parameter, exact solutions are known. In particular, for one of these values, when the solution is chaotic, an exact solution in terms of the square of the sine function is known. In this study, a general solution for the logistic map for all values of the control parameter in a continuous range is proposed. This solution employs a special function, not expressible in terms of known analytical functions. A method of calculating this function numerically, as well as calculating its inverse numerically is proposed and some of its properties are discussed. This study, therefore, contributes to the field of nonlinear dynamics by introducing a novel tool for visualization and for investigation. The technique may be extendable to other nonlinear maps

Vertex-Coloring with Star-Defects

Defective coloring is a variant of traditional vertex-coloring, according to which adjacent vertices are allowed to have the same color, as long as the monochromatic components induced by the corresponding edges have a certain structure. Due to its important applications, as for example in the bipartisation of graphs, this type of coloring has been extensively studied, mainly with respect to the size, degree, and acyclicity of the monochromatic components. In this paper we focus on defective colorings in which the monochromatic components are acyclic and have small diameter, namely, they form stars. For outerplanar graphs, we give a linear-time algorithm to decide if such a defective coloring exists with two colors and, in the positive case, to construct one. Also, we prove that an outerpath (i.e., an outerplanar graph whose weak-dual is a path) always admits such a two-coloring. Finally, we present NP-completeness results for non-planar and planar graphs of bounded degree for the cases of two and three colors

Comparing gene expression profiles of adults with isolated spinal tuberculosis to disseminated spinal tuberculosis identified by 18^{18}FDG-PET/CT at time of diagnosis, 6- and 12-months follow-up: classifying clinical stages of spinal tuberculosis and monitoring treatment response (Spinal TB X cohort study)

BACKGROUND: Tuberculosis (TB) is one of the top ten causes of death worldwide, with approximately 10 million cases annually. Focus has been on pulmonary TB, while extrapulmonary TB (EPTB) has received little attention. Diagnosis of EPTB remains challenging due to the invasive procedures required for sample collection. Spinal TB (STB) accounts for 10% of EPTB and often leads to lifelong debilitating disease due to devastating spinal deformation and compression of neural structures. Little is known about the extent of disease, although both isolated STB and a disseminated form of STB have been described. In our Spinal TB X cohort study, we aim to describe the clinical phenotype of STB using whole-body $^{18}$FDG-PET/CT, identify a specific gene expression profile for different stages of dissemination and compare findings to previously described gene expression signatures for latent and active pulmonary TB. METHODS: A single-centre, prospective cohort study will be established to describe the distributional pattern of STB detected by whole-body $^{18}$FDG-PET/CT and gene expression profile of patients with suspected STB on magnetic resonance imaging (MRI) at point of diagnosis, six months, and 12 months. Blood biobanking will be performed at these time points. Specimens for microbiology will be obtained from sputum/urine, from easily accessible sites of disease (e.g., lymph nodes, abscess) identified in the first $^{18}$FDG-PET/CT, from CT-guided biopsy and/or surgery. Clinical parameters and functional scores will be collected at every physical visit. Data will be entered into RedCap® database; data cleaning, validation and analysis will be performed by the study team. The University of Cape Town Ethics Committee approved the protocol (243/2022). DISCUSSION: The Spinal TB X cohort study is the first prospective cohort study using whole-body 18FDG-PET/CT scans in patients with microbiologically confirmed spinal tuberculosis. Dual imaging techniques of the spine using $^{18}$FDG-PET/CT and magnetic resonance imaging as well as tissue diagnosis (microbiology and histopathology) will allow us to develop a virtual biopsy model. If successful, a distinct gene-expression profile will aid in blood-based diagnosis (point of care testing) as well as treatment monitoring and would lead to earlier diagnosis of this devastating disease

Inhibition of TGF-β Signaling and Decreased Apoptosis in IUGR-Associated Lung Disease in Rats

Intrauterine growth restriction is associated with impaired lung function in adulthood. It is unknown whether such impairment of lung function is linked to the transforming growth factor (TGF)-β system in the lung. Therefore, we investigated the effects of IUGR on lung function, expression of extracellular matrix (ECM) components and TGF-β signaling in rats. IUGR was induced in rats by isocaloric protein restriction during gestation. Lung function was assessed with direct plethysmography at postnatal day (P) 70. Pulmonary activity of the TGF-β system was determined at P1 and P70. TGF-β signaling was blocked in vitro using adenovirus-delivered Smad7. At P70, respiratory airway compliance was significantly impaired after IUGR. These changes were accompanied by decreased expression of TGF-β1 at P1 and P70 and a consistently dampened phosphorylation of Smad2 and Smad3. Furthermore, the mRNA expression levels of inhibitors of TGF-β signaling (Smad7 and Smurf2) were reduced, and the expression of TGF-β-regulated ECM components (e.g. collagen I) was decreased in the lungs of IUGR animals at P1; whereas elastin and tenascin N expression was significantly upregulated. In vitro inhibition of TGF-β signaling in NIH/3T3, MLE 12 and endothelial cells by adenovirus-delivered Smad7 demonstrated a direct effect on the expression of ECM components. Taken together, these data demonstrate a significant impact of IUGR on lung development and function and suggest that attenuated TGF-β signaling may contribute to the pathological processes of IUGR-associated lung disease

Nicotine exposure and transgenerational impact: a prospective study on small regulatory microRNAs

Early developmental stages are highly sensitive to stress and it has been reported that pre-conditioning with tobacco smoking during adolescence predisposes those youngsters to become smokers as adults. However, the molecular mechanisms of nicotine-induced transgenerational consequences are unknown. In this study, we genome-widely investigated the impact of nicotine exposure on small regulatory microRNAs (miRNAs) and its implication on health disorders at a transgenerational aspect. Our results demonstrate that nicotine exposure, even at the low dose, affected the global expression profiles of miRNAs not only in the treated worms (F0 parent generation) but also in two subsequent generations (F1 and F2, children and grandchildren). Some miRNAs were commonly affected by nicotine across two or more generations while others were specific to one. The general miRNA patterns followed a “two-hit� model as a function of nicotine exposure and abstinence. Target prediction and pathway enrichment analyses showed daf-4, daf-1, fos-1, cmk-1, and unc-30 to be potential effectors of nicotine addiction. These genes are involved in physiological states and phenotypes that paralleled previously published nicotine induced behavior. Our study offered new insights and further awareness on the transgenerational effects of nicotine exposed during the vulnerable post-embryonic stages, and identified new biomarkers for nicotine addiction.ECU Open Access Publishing Support Fun