The divestment-reinvestment sequence in foreign countries: The role of relational vs. transactional ownership

In this paper, we claim that ownership is a key determinant of the firms' divestment-reinvestment sequence in a foreign country. Building on the notion of ‘relational vs. transactional ownership’, we distinguish between relational-type firms (namely, family-owned and state-owned firms), and transactional-type firms (privately non-family-owned firms). We argue that relational-type firms are less likely to both divest from, and reinvest in, a given foreign country. In fact, relational owners set a lower performance threshold of intervention than transactional ones; additionally, in order to turn the tide, the former often increase resource injection when subsidiary performance falls below the threshold. Such an escalation of commitment increases sunk costs and further decreases the likelihood of divesting the subsidiary. Moreover, when a divestment occurs, the memory of high sunk costs incurred reduces the propensity to reinvest in the same host country. We test our conceptual framework on a large sample of investments, divestments and subsequent re-entries undertaken in the period 2000–2015 by 602 Italian firms. Our econometric findings corroborate our hypotheses, thus contributing to the literature on the interdependencies between divestment and reinvestment choices, and their relationships with corporate ownership

Culture of human cell lines by a pathogen-inactivated human platelet lysate

Alternatives to the use of fetal bovine serum (FBS) have been investigated to ensure xeno-free growth condition. In this study we evaluated the efficacy of human platelet lysate (PL) as a substitute of FBS for the in vitro culture of some human cell lines. PL was obtained by pools of pathogen inactivated human donor platelet (PLT) concentrates. Human leukemia cell lines (KG-1, K562, JURKAT, HL-60) and epithelial tumor cell lines (HeLa and MCF-7) were cultured with either FBS or PL. Changes in cell proliferation, viability, morphology, surface markers and cell cycle were evaluated for each cell line. Functional characteristics were analysed by drug sensitivity test and cytotoxicity assay. Our results demonstrated that PL can support growth and expansion of all cell lines, although the cells cultured in presence of PL experienced a less massive proliferation compared to those grown with FBS. We found a comparable percentage of viable specific marker-expressing cells in both conditions, confirming lineage fidelity in all cultures. Functionality assays showed that cells in both FBS- and PL-supported cultures maintained their normal responsiveness to adriamycin and NK cell-mediated lysis. Our findings indicate that PL is a feasible serum substitute for supporting growth and propagation of haematopoietic and epithelial cell lines with many advantages from a perspective of process standardization, ethicality and product safety

A possible solution for dinamically managing virtual environments

In modern distributed computer systems (clusters and computing GRIDs) a new class of problems, due to the increasing heterogeneity of users’ needs, have to be tackled by the administrators. One possible solution is to create ondemand virtual working environments tailored on the user’s requirements. Hence the need for an architecture to manage dynamically such environments. In this work we propose a possible solution based on the use of Virtual Machines (Xen), the implementation of a Virtual Machine Manager, capable of creation, destruction and migration of the virtualized working environments. The information will be collected using a client-server mechanism, to allow the manager to deploy preconfigured Virtual Machines on the available hardware resources. When a new execution environment became active, it is automatically recognized by the Batch System Manager and is then ready to be used

The importance of root interactions in field bean/triticale intercrops

To highlight the contribution of belowground interactions to biomass and N and P yields, field bean and triticale were grown in a P-poor soil as sole crops and as replacement intercrops at two N levels. The shoots were always in contact, while the roots of adjacent rows were free to interact or were completely separated. This allowed simultaneous testing the intraspecific and interspecific competition between rows, which to our knowledge has not been studied before. Root biomass, distribution in soil, morphometry, and functional traits were determined, together with the nodule number and biomass. The Land Equivalent Ratio for shoot biomass and N and P yield were higher than 1 when roots were in contact, and markedly lower when they were separated. This demonstrates the positive contribution of root interactions, which in field bean, consisted of increased root elongation without changes in biomass and nutrient status; in triticale, of increased N and P uptake eciency and reduced biomass partitioning to roots. The soil-plant processes underlying intercrop advantage led to complementarity in N sources with low N inputs and facilitated N and P uptake with high N inputs, which demonstrates that intercropping could be profitable in both low and high input agriculture

On Designing a Time Sensitive Interaction Graph to Identify Twitter Opinion Leaders

What happened on social media during the recent pandemic? Who was the opinion leader of the conversations? Who influenced whom? Were they medical doctors, ordinary people, scientific experts? Did health institutions play an important role in informing and updating citizens? Identifying opinion leaders within social platforms is of particular importance and, in this paper, we introduce the idea of a time sensitive interaction graph to identify opinion leaders within Twitter conversations. To evaluate our proposal, we focused on all the tweets posted on Twitter in the period 2020-21 and we considered just the ones that were Italian-written and were related to COVID-19. After mapping these tweets into the graph, we applied the PageRank algorithm to extract the opinion leaders of these conversations. Results show that our approach is effective in identifying opinion leaders and therefore it might be used to monitor the role that specific accounts (i.e., health authorities, politicians, city administrators) have within specific conversations

Unscreening the Gaugino Mass with Chiral Messengers

Gaugino screening, the absence of next-to-leading order corrections to gaugino masses, is a generic feature of gauge mediation models of supersymmetry breaking. We show that in a specific class of models, known as semi-direct gauge mediation, it is possible to avoid gaugino screening by allowing for a chiral messenger sector. Messengers then acquire a mass at some scale, for instance by higgsing or by some auxiliary strong coupling dynamics. We implement this idea in a simple model which we work out explicitly

Discovery of very high energy gamma-rays from the flat spectrum radio quasar 3C 279 with the MAGIC telescope

3C 279 is one of the best studied flat spectrum radio quasars located at a comparatively large redshift of z = 0.536. Observations in the very high energy band of such distant sources were impossible until recently due to the expected steep energy spectrum and the strong gamma-ray attenuation by the extragalactic background light photon field, which conspire to make the source visible only with a low energy threshold. Here the detection of a significant gamma-ray signal from 3C 279 at very high energies (E > 75 GeV) during a flare in early 2006 is reported. Implications of its energy spectrum on the current understanding of the extragalactic background light and very high energy gamma-ray emission mechanism models are discussed.Comment: 4 pages, 6 figures, submitted to proceedings of "4th Heidelberg International Symposium on High Energy Gamma-Ray Astronomy 2008

Soybean meal-dependent intestinal inflammation induces different patterns of bone-loss in adult zebrafish scale

Inflammatory bowel disease have been linked to several health issues, including high risk of low bone mineral density. Danio rerio (zebrafish) is a good model to verify the effects of intestinal inflammation, since its gastrointestinal and immune systems are closely related to that of mammalians. Zebrafish is also a powerful model to study bone metabolism using the scale as the read-out model. Food strongly impacts zebrafish gut physiology, and it is well known that soybean meal induces intestinal inflammation. Adult zebrafish fed with defatted soybean meal (SBM) exhibited an intestinal inflammation evidenced by morphological alterations, inflammatory infiltrate, and increased mRNA expression of inflammatory cytokines (IL-1\u3b2, IL-6, IL-8, IL-10, TGF\u3b2, TNF-\u3b1). The peak of acute intestinal inflammation, spanning between week 2 and 3, correlates with a transitory osteoporosis-like phenotype in the scale border. Later, a chronic inflammatory condition, associated with persistent IL-8 expression, correlates with the progression of resorption lacunae in the scale center. Both types of resorption lacunae were associated with intense osteoclastic tartrate-resistant acid phosphatase (TRAP) activity. After 3 weeks of SBM treatment, osteoclast activity decreased in the scale border but not in the center. At the same time, alkaline phosphatase (ALP) is activated in the border to repair the bone matrix. This model can contribute to elucidate in vivo the molecular mechanisms that links intestinal inflammation and bone metabolism in IBD