Nutrire Roma: il ruolo dell’agricoltura urbana nel fenomeno urbano

Scopo di questa nota è di esaminare i caratteri e le dinamiche che connotano l’agricoltura urbana nel caso di Roma. Il contributo sintetizza in chiave evolutiva i fatti stilizzati del rapporto tra città e campagna, successivamente si indaga il contesto produttivo agricolo al fine di proporre una tassonomia dei tipi di agricoltura urbana. Il tentativo che qui si propone è una preliminare lettura dell’agricoltura urbana attraverso un sistema di criteri per la classificazione della distribuzione funzionale e relazionale del primario in aree metropolitane. Tali categorie interpretative tentano di ricostruire le relazioni causali che traducono i modelli produttivi agricoli (caratteristiche strutturali, ordinamenti, forme giuridiche, forme d’uso delle risorse naturali, collocazione), in specifiche forme spaziali e funzionali nella dimensione urbana – fisica e sociale -. Sul piano teorico tale lettura s’inserisce nel paradigma coevolutivo e guarda al paesaggio come il risultato delle interazioni tra il sistema ambientale e l’agire dell’uomo che abita e utilizza il territorio (Marino e Cavallo, 2009). Una sintesi tipologica definitiva sembra ancora un obiettivo da raggiungere, sicuramente questo è il primo passo verso la costruzione di una griglia interpretativa e di un vocabolario tipologico da mettere poi a sistema con i dati morfologici e quelli di uso del suolo.The aim of this paper is to examine the characteristics and the dynamics that characterize urban agriculture in the case of Rome. We summarize in an evolutionary approach the stylized facts of the relationship between town and country, then we investigate the context of agricultural production in order to propose a taxonomy of the types of urban agriculture. The effort proposed here is a preliminary analysis of urban agriculture through a system of criteria for the classification of the distribution of the functional and relational features of agricultural activities in metropolitan areas. These interpretative categories attempt to reconstruct the causal relationships that translate agricultural production models (farms’ data, legal forms, use of natural resources, localization), in specific forms in the spatial and functional urban dimension - physical and social - . On the theoretical level this analysis is embedded in the co-evolutionary paradigm and looks to the landscape as the result of interactions between the environmental system and the action of human who lives and uses the territory (Marino and Cavallo, 2009). This typization ultimately still seems a goal to achieve, this is the first step towards the construction of an interpretative and vocabulary typological then be systematize with the morphological data and those of land use.Peer Reviewe

A solid-state platform for cooperative quantum phenomena

The dissipation resulting from the coupling of a system with its environment is commonly viewed as a foe for quantum technologies. Nonetheless, recent developments at light-matter interfaces have shown that correlated dissipation can be leveraged to engineer novel dynamical states of matter and entanglement in many-body quantum systems. Inspired by this progress, here we set the stage for the -- yet uncharted -- exploration of cooperative quantum phenomena in quantum hybrid solid-state platforms. We develop a comprehensive formalism for the quantum many-body dynamics of an ensemble of solid-state spin defects interacting via the magnetic field fluctuations of a common solid-state reservoir. Our general framework captures effective qubit-qubit interactions mediated by correlated dissipation and naturally extends the theory of quantum sensing of local magnetic noise via single solid-state spin defects to sensing of nonlocal temporal and spatial correlations. To understand whether dissipative correlations can play a relevant role in a realistic experimental setup, we apply our model to a qubit array interacting via the spin fluctuations of a ferromagnetic reservoir. Our results show that collective relaxation rates of an ensemble of solid-state spin defects placed nearby a common ferromagnetic thin film can display clear signatures of superradiance and subradiance in the appropriate parameter regime. Furthermore, we find that the cooperative quantum behavior exhibits remarkable robustness against spatial disorder and thermal fluctuations. Our work lays the foundation for merging spintronics and quantum optics towards a common research horizon in the incoming future

Effect of cadmium on anion exchange capability through Band 3 protein in human erythrocytes

The efficiency of Band 3 protein, mediating HCO3-/Cl- exchange across erythrocytes membrane, is reduced by oxidative stress. The aim of the present study was to verify whether Band 3 protein efficiency is compromised by treatment with Cadmium (Cd2+), an extremely toxic heavy metal known to interfere with antioxidant enzymes, energy metabolism, gene expression and cell membranes. To this end, the rate constant for SO4= uptake through Band 3 protein (accounting for velocity of anion exchange) was measured along with membrane –SH groups, Malonyldialdehyde (MDA) and Band 3 protein expression levels in Cd2+ -treated human erythrocytes (300 µM, 1 mM). Our results show that Cd2+ reduced the rate constant for SO4= uptake, with a significant increase in MDA levels at both concentrations and with a reduction in –SH groups observed after 1 mM Cd2+ treatment, whereas Band 3 protein expression levels were unchanged in both conditions. In conclusion: i) Cd2+ reduces Band 3 protein efficiency via different mechanisms depending on metal concentration and with unchanged expression levels; ii) the assessment of Band 3 protein anion exchange capability is a good tool to assay the impact of heavy metals on cell homeostasis and, possibly, useful for diagnosis and monitoring of devalopment of Cd2+ toxicity-related pathologies

Il cibo come questione territoriale. Riflessioni alla luce della pianificazione alimentare

In the recent years, agriculture has played a key role in reshaping rurality, in the view of a reconstruction of social and production structures accompanying the current re-territorialisation process, coming after a phase of de-territorialisation of the role of the agricultural sector as the focus of local balances. At the same time, the contemporary urban phenomenon is rewriting, even though not orderly, its relationship with agriculture and food, overcoming the traditional idea of city in which countryside is only extra muros. If the main experiences of the Italian food policies have concerned the great urban systems, the topic here discussed are food policies as an opportunity, offered to Italian small and medium-sized centres, to re-contextualise their own agro-food systems and their functions for the community. The ability of plans and policies to understand and orientate these processes shows, actually, growing difficulties. The breadth between civic or market practices and the regulatory, political and planning framework is territory, the place where we should build and experience new forms of governance, institutions and tools where citizenship, labour and market meet agriculture and territorial diversity. The paper focuses on the meaning and functions of food planning and discusses some possible implementation on the polycentric geography of the Italian territory

Comparison between First- and Second-Generation Cryoballoon for Paroxysmal Atrial Fibrillation Ablation

Introduction. Cryoballoon (CB) ablation has emerged as a novel treatment for pulmonary vein isolation (PVI) for patients with paroxysmal atrial fibrillation (PAF). The second-generation Arctic Front Advance (ADV) was redesigned with technical modifications aiming at procedural and outcome improvements. We aimed to compare the efficacy of the two different technologies over a long-term follow-up. Methods. A total of 120 patients with PAF were enrolled. Sixty patients underwent PVI using the first-generation CB and 60 patients with the ADV catheter. All patients were evaluated over a follow-up period of 2 years. Results. There were no significant differences between the two groups of patients. Procedures performed with the first-generation CB showed longer fluoroscopy time (36.3±16.8 versus 14.2±13.5 min, resp.; p=0.00016) and longer procedure times as well (153.1±32 versus 102±24.8 min, resp.; p=0.019). The overall long-term success was significantly different between the two groups (68.3 versus 86.7%, resp.; p=0.017). No differences were found in the lesion areas of left and right PV between the two groups (resp., p=0.61 and 0.57). There were no significant differences in procedural-related complications. Conclusion. The ADV catheter compared to the first-generation balloon allows obtaining a significantly higher success rate after a single PVI procedure during the long-term follow-up. Fluoroscopy and procedural times were significantly shortened using the ADV catheter

Comparison between First-and Second-Generation Cryoballoon for Paroxysmal Atrial Fibrillation Ablation

Introduction. Cryoballoon (CB) ablation has emerged as a novel treatment for pulmonary vein isolation (PVI) for patients with paroxysmal atrial fibrillation (PAF). The second-generation Arctic Front Advance (ADV) was redesigned with technical modifications aiming at procedural and outcome improvements. We aimed to compare the efficacy of the two different technologies over a long-term follow-up. Methods. A total of 120 patients with PAF were enrolled. Sixty patients underwent PVI using the firstgeneration CB and 60 patients with the ADV catheter. All patients were evaluated over a follow-up period of 2 years. Results. There were no significant differences between the two groups of patients. Procedures performed with the first-generation CB showed longer fluoroscopy time (36.3 ± 16.8 versus 14.2 ± 13.5 min, resp.; = 0.00016) and longer procedure times as well (153.1 ± 32 versus 102±24.8 min, resp.; = 0.019). The overall long-term success was significantly different between the two groups (68.3 versus 86.7%, resp.; = 0.017). No differences were found in the lesion areas of left and right PV between the two groups (resp., = 0.61 and 0.57). There were no significant differences in procedural-related complications. Conclusion. The ADV catheter compared to the first-generation balloon allows obtaining a significantly higher success rate after a single PVI procedure during the long-term follow-up. Fluoroscopy and procedural times were significantly shortened using the ADV catheter

A Fondazione Italiana Linfomi cohort study of R-COMP vs R-CHOP in older patients with diffuse large B-cell lymphoma

: Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is the most commonly used regimen for the upfront treatment of diffuse large B-cell lymphoma (DLBCL). However, it is associated with cardiotoxicity, especially in older patients. Substituting doxorubicin with non-PEGylated liposomal doxorubicin (R-COMP) may reduce the risk of cardiac events, but its efficacy has never been demonstrated in prospective trials. We describe the characteristics and outcome of patients with DLBCL aged ≥65 years prospectively enrolled in the Elderly Project by the Fondazione Italiana Linfomi and treated with full doses of R-CHOP or R-COMP per local practice. Starting from 1163 patients, 383 (55%) were treated with R-CHOP and 308 (45%) with R-COMP. Patients treated with R-COMP were older (median age, 76 vs 71 years), less frequently fit at simplified geriatric assessment (61% vs 88%; P < .001), and had a more frequent baseline cardiac disorders (grade >1, 32% vs 8%; P < .001). Three-year progression-free survival (PFS) was similar between R-CHOP and R-COMP (70% and 64%); 3-year overall survival was 77%, and 71% respectively. R-CHOP was associated with better PFS vs R-COMP only in the Elderly Prognostic Index (EPI) low-risk group. The two groups had similar rates of treatment interruptions due to toxicities or of cardiac events (P = 1.00). We suggest R-COMP is a potentially curative treatment for older patients with intermediate- or high-risk EPI, even in the presence of a baseline cardiopathy. R-CHOP is confirmed as the standard therapy for low risk patients

Effects of robotic upper limb treatment after stroke on cognitive patterns: A systematic review

Background: Robotic therapy (RT) has been internationally recognized for the motor rehabilitation of the upper limb. Although it seems that RT can stimulate and promote neuroplasticity, the effectiveness of robotics in restoring cognitive deficits has been considered only in a few recent studies. Objective: To verify whether, in the current state of the literature, cognitive measures are used as inclusion or exclusion criteria and/or outcomes measures in robotic upper limb rehabilitation in stroke patients. Methods: The systematic review was conducted according to PRISMA guidelines. Studies eligible were identified through PubMed/MEDLINE and Web of Science from inception to March 2021. Results: Eighty-one studies were considered in this systematic review. Seventy-three studies have at least a cognitive inclusion or exclusion criteria, while only seven studies assessed cognitive outcomes. Conclusion: Despite the high presence of cognitive instruments used for inclusion/exclusion criteria their heterogeneity did not allow the identification of a guideline for the evaluation of patients in different stroke stages. Therefore, although the heterogeneity and the low percentage of studies that included cognitive outcomes, seemed that the latter were positively influenced by RT in post-stroke rehabilitation. Future larger RCTs are needed to outline which cognitive scales are most suitable and their cut-off, as well as what cognitive outcome measures to use in the various stages of post-stroke rehabilitation

Novel aryl substituted pyrazoles as small molecule inhibitors of cytochrome P450 CYP121A1: Synthesis and antimycobacterial evaluation

Three series of biarylpyrazole imidazole and triazoles are described, which vary in the linker between the biaryl pyrazole and imidazole/triazole group. The imidazole and triazole series with the short −CH2– linker displayed promising antimycobacterial activity, with the imidazole–CH2– series (7) showing low MIC values (6.25–25 μg/mL), which was also influenced by lipophilicity. Extending the linker to −C(O)NH(CH2)2– resulted in a loss of antimycobacterial activity. The binding affinity of the compounds with CYP121A1 was determined by UV–visible optical titrations with KD values of 2.63, 35.6, and 290 μM, respectively, for the tightest binding compounds 7e, 8b, and 13d from their respective series. Both binding affinity assays and docking studies of the CYP121A1 inhibitors suggest type II indirect binding through interstitial water molecules, with key binding residues Thr77, Val78, Val82, Val83, Met86, Ser237, Gln385, and Arg386, comparable with the binding interactions observed with fluconazole and the natural substrate dicyclotyrosine

The clinical effectiveness of an integrated multidisciplinary evidence-based program to prevent intraoperative pressure injuries in high-risk children undergoing long-duration surgical procedures: a quality improvement study

The prevention of hospital-acquired pressure injuries (HAPIs) in children undergoing long-duration surgical procedures is of critical importance due to the potential for catastrophic sequelae of these generally preventable injuries for the child and their family. Long-duration surgical procedures in children have the potential to result in high rates of HAPI due to physiological factors and the difficulty or impossibility of repositioning these patients intraoperatively. We developed and implemented a multi-modal, multi-disciplinary translational HAPI prevention quality improvement program at a large European Paediatric University Teaching Hospital. The intervention comprised the establishment of wound prevention teams, modified HAPI risk assessment tools, specific education, and the use of prophylactic dressings and fluidized positioners during long-duration surgical procedures. As part of the evaluation of the effectiveness of the program in reducing intraoperative HAPI, we conducted a prospective cohort study of 200 children undergoing long-duration surgical procedures and compared their outcomes with a matched historical cohort of 200 children who had undergone similar surgery the previous year. The findings demonstrated a reduction in HAPI in the intervention cohort of 80% (p < 0.01) compared to the comparator group when controlling for age, pathology, comorbidity, and surgical duration. We believe that the findings demonstrate that it is possible to significantly decrease HAPI incidence in these highly vulnerable children by using an evidence-based, multi-modal, multidisciplinary HAPI prevention strategy