Knowledge of French Healthcare Workers about Antimicrobial Resistance: a Large Multicentre Study

International audienc

Connaissances médicales et paramédicales sur l'antibiorésistance bactérienne et l'application des préventions de transmission

International audienc

Comparison of antibiotic treatment guidelines for urinary tract infections in 15 European countries: Results of an online survey

Appropriate antibiotic use for urinary tract infections (UTIs) is important in order to provide effective and safe treatment while minimising the risk of antimicrobial resistance development. This survey was carried out to compare existing national guidelines for UTIs in Europe. Experts in 37 European countries were asked to participate. An electronic questionnaire was used to obtain information on treatment recommendations, factors considered important when setting guidelines, acceptable resistance rates for empirical therapy, evidence grading, and existing resistance surveillance for uropathogens. Treatment guidelines and antimicrobial susceptibility data were collected. In total, 22 experts (59%) responded to the survey. National guidelines were missing in four countries and data were incomplete in three cases. Fifteen national guidelines published between 2004 and 2017 were included in the analysis. Great variability was found between guidelines in the selection of antibiotics, dosing regimens and treatment duration. For example, 10 different antibiotics were recommended as first-line therapy for uncomplicated cystitis. National surveillance data on antimicrobial susceptibility of uropathogens were available in 13 of 15 countries. Resistance epidemiology could not explain the observed differences between guidelines, and comparison of resistance rates was hampered by variations in methods. This study revealed major differences in treatment guidelines for UTIs within Europe, indicating that there are opportunities for improvement. More clinical research and a more systematic and stratified approach to resistance surveillance, including also antibiotics that are currently not available in all countries, is needed.status: publishe

Working Group on Fisheries Benthic Impact and Trade-offs (WGFBIT; outputs from 2021 meeting)

The Working Group on Fisheries Benthic Impact and Trade-offs (WGFBIT) develops methods and performs assessments to evaluate benthic impact from fisheries at regional scale, while considering fisheries and seabed impact trade-offs.In this report, new fishery benthic impact assessments are carried out for several sub-regions in the Mediterranean (Greek waters, South Adriatic Sea, Sicily waters). For other regions, updates of the whole assessment or specific steps only were presented. A standard advice sheet for the regional benthic assessments, intended as input to the next generation of the ICES Ecosystem and Fisheries Overviews, was finalised and compiled for some regions as example (Greek waters, Baltic Sea). A validation of the longevity relationships using new data was executed for the Kattegat area and the Southern North Sea. In relation to the methodology, some recommendations were formulated concerning the update on depletion rates, the use of epifauna- or infauna-based data, guidance on which set of epibenthic species to include and the time scale for setting the average swept-area-ratio (SAR) used in model fitting and assessment. A benchmarking process comparing available benthic impact assessment approaches for MSFD descriptor 6 “Seafloor integrity” is needed, as the WGFBIT approach (relative benthic state) is not the only way to assess benthic impacts from physical disturbances. A start was made to explore how to incorporate more explicitly ecosystem functioning in to the WGFBIT seafloor assessment methodology. An improved understanding of the relationships between total community biomass and ecosystem functioning may assist in setting acceptable thresholds for ecosystem impacts from trawling. Furthermore, an improved understanding of the link between species functional effect traits and proxies and processes for specific ecosystem functions could help increase our ability to predict the impact of fishing disturbance on benthic ecosystem functioning more accurately. The ecosystem function we focus on is the biogeochemical cycling of organic matter. Two approaches were discussed (i) Biological traits approach focusing on the linkage between biological traits and eco-system functions and (ii) biogeochemical modelling approach using the established the OMEXDIA model

Selective reporting of antibiotic susceptibility test results in European countries: an ESCMID cross-sectional survey

International audienc