Information Technology Governance Processes Under Environmental Dynamism: Investigating Competing Theories of Decision Making and Knowledge Sharing

This paper describes an empirical study of IT governance processes in complex organizations under conditions of environmental dynamism. Rooted in competing theories of organizational decision making and knowledge sharing, and based on a case study investigation of large, distributed organizations, this study examines the design and effectiveness of IT governance processes from both rational-analytical and social-learning perspectives. The results indicate that, regardless of the level of environmental dynamism, effective IT governance processes are characterized by both methodological comprehensiveness and social capabilities. The implications for theory development, future research, and IT governance practices are discussed

Assessing the Impact of the Ultimate Penal Sanction on Homicide Survivors: A Two State Comparison

Numerous studies have examined the psychological sequelae that result from the murder of a loved one. Except for the death penalty, however, sparse attention has been paid to the impact of the murderer’s sentence on homicide survivors’ well-being. Given the steadfastness of the public’s opinion that the death penalty brings satisfaction and closure to survivors, it is surprising that there has been no systematic inquiry directly with survivors about whether obtaining the ultimate punishment affects their healing. This Study used in-person interviews with a randomly selected sample of survivors from four time periods to examine the totality of the ultimate penal sanction (UPS) process and its longitudinal impact on their lives. Moreover, it assessed the differential effect of two types of UPS by comparing survivors’ experiences in Texas, a death penalty state, and Minnesota, a life without the possibility of parole (LWOP) state. Comparing states highlights differences primarily during the postconviction stage, specifically with respect to the appeals process and in regard to survivor well-being. In Minnesota, survivors of adjudicated cases show higher levels of physical, psychological, and behavioral health. This Study’s findings have implications for trial strategy and policy development

Restorative Justice and Dialogue: Impact, Opportunities, and Challenges in the Global Community

The Article focuses on the Community of Veterans Engaged in Restoration (COVER) restorative justice program offered by the Sheriff\u27s Department of San Francisco, California. Information is provided on how the program aims to prevent crimes by U.S. veterans, focuses on offender accountability, and promotes community involvement

Group Differences in Hot and Cool Executive Functioning Performance in College Students with and without a History of Child Maltreatment

We explored the degree to which a history of child maltreatment impacts performance in college settings. In recent studies, researchers have explored “hot” versus “cool” executive functioning (EF). Cool EF is comprised of cognitive processes in non-emotional settings and are known to play an important role in educational achievement. Hot EF is comprised of cognitive processes supported by emotional awareness. Given that child maltreatment is associated with emotional arousal difficulty, we explored the degree to which hot and cold EF tasks are differentially impacted by a history of child maltreatment. Our research approach involved modifying two traditional cool EF tasks (Tower of London and Go/No Go) in order to compare an individual’s performance in both the cool and heated version of the task. An important aspect of our study involved comparing the relative impact of a “social heating” (i.e., emotion faces) versus a “nonsocial heating” (monetary reward). We believed individuals with a maltreatment history would show relatively more difficulty with social heating. The data suggested that there were some sensible correlations between the subscales of a trauma questionnaire and other EF measures. Overall, we were unable to find clear group effects suggesting that a larger sample size would be beneficial

African Americans and Recovery from Severe Mental Illness

This mixed methods study examined the lived experience of African American persons recovering from serious and persistent mental illness (SPMI) and assessed changes in demoralization, engulfment and coping over time. Psychological measures were administered and semi-structured interviews were conducted at three time points (6, 12, and 18 months) with nine African Americans with SPMI. Qualitative analysis was done from an Afrocentric perspective. The interviews were transcribed, read and coded to cluster thematic aspects in each case and across cases. Atlas-ti was used to recode transcripts and retrieve quotes to dimensionalize each essential theme. Four themes were identified: 1) striving for normalcy, 2) striving for a positive and proactive outlook, 3) mastering the challenges posed by mental illness, and 4) leaning on the supports that watch out for and over me. Paired t-tests were performed on the dependent variables of demoralization, coping, and engulfment. There was a significant change in reduction of demoralization and increase in coping from Time 1 to Time 2. There was no significant change in engulfment. These changes are noteworthy as participants averaged 21 years of illness. The relationship between the quantitative results and qualitative findings are discussed. Results have implications for practice and improving recovery-oriented services to African Americans. For example, case managers are advised to consider mental health stigma and anti stigma interventions that are inclusive of racial discrimination and expand their cultural sensitivity to include the sense of endangerment experienced by African American clients. Four African American consultants critiqued the study anonymously

The impact of statistical adjustment on economic profiles of interventional cardiologists

AbstractOBJECTIVESThe objective of this study was to identify preprocedure patient factors associated with percutaneous intervention costs and to examine the impact of these patient factors on economic profiles of interventional cardiologists.BACKGROUNDThere is increasing demand for information about comparative resource use patterns of interventional cardiologists. Economic provider profiles, however, often fail to account for patient characteristics.METHODSData were obtained from Duke Medical Center cost and clinical information systems for 1,949 procedures performed by 13 providers between July 1, 1997, and December 31, 1998. Patient factors that influenced cost were identified using multiple regression analysis. After assessing interprovider variation in unadjusted cost, mixed linear models were used to examine how much cost variability was associated with the provider when patient characteristics were taken into account.RESULTSTotal hospital costs averaged $15,643 (median,$13,809), $6,515 of which represented catheterization laboratory costs. Disease severity, acuity, comorbid illness and lesion type influenced total costs (R2= 38%), whereas catheterization costs were affected by lesion type and acuity (R2= 32%). Patient characteristics varied significantly among providers. Unadjusted total costs were weakly associated with provider, and this association disappeared after accounting for patient factors. The provider influence on catheterization costs persisted after adjusting for patient characteristics. Furthermore, the pattern of variation changed: the adjusted analysis identified three new outliers, and two providers lost their outlier status. Only one provider was consistently identified as an outlier in the unadjusted and adjusted analyses.CONCLUSIONSEconomic profiles of interventional cardiologists may be misleading if they do not adequately adjust for patient characteristics before procedure

The Iowa Homemaker vol.23, no.10

Keeping Up With Today, Marilyn Clayton, page 2 Victory Canning Corps, Corinne Cunningham, page 3 Posters for South America, Frances Kerekes, page 4 Choosing Your College, Clara M. Brown, page 5 For Random Reading, Lila Mae Hummel, page 7 Wanted: More Home Economics, Victoria McKibben, page 9 Teaching Field Broadens in Scope, Norma Shellito, page 10 Food Customs from the Phillipines, Soledad Payawal, page 11 Sheer Simplicity, Josephine Ahern, page 12 Association Benefits Graduates, Zoe Wilson, page 14 Forecasting Textile Supply, Elizabeth Peterson, page 15 What’s New in Home Economics, Mildred Krogh, page 16 Packaging for Post War Foods, Virginia Carter, page 18 Challenge from Latin America, Delores Stewart, page 19 Designed for Individuality, Gertrude Richards, page 21 More Products from Plastics, Mary Elizabeth Lush, page 23 Fashions in Weeds, Marilyn Baker, page 24 Across Alumnae Desks, Harriet Keen, page 26 Rehabilitation Challenges Home Economist, Marian Hoppe, page 28 Alums in the News, Patricia Maddex, page 30 Electronics Change Food Flavors, Barbara Reader, page 3

Omega-3 Fatty Acids Reduce Adipose Tissue Macrophages in Human Subjects with Insulin Resistance

Fish oils (FOs) have anti-inflammatory effects and lower serum triglycerides. This study examined adipose and muscle inflammatory markers after treatment of humans with FOs and measured the effects of ω-3 fatty acids on adipocytes and macrophages in vitro. Insulin-resistant, nondiabetic subjects were treated with Omega-3-Acid Ethyl Esters (4 g/day) or placebo for 12 weeks. Plasma macrophage chemoattractant protein 1 (MCP-1) levels were reduced by FO, but the levels of other cytokines were unchanged. The adipose (but not muscle) of FO-treated subjects demonstrated a decrease in macrophages, a decrease in MCP-1, and an increase in capillaries, and subjects with the most macrophages demonstrated the greatest response to treatment. Adipose and muscle ω-3 fatty acid content increased after treatment; however, there was no change in insulin sensitivity or adiponectin. In vitro, M1-polarized macrophages expressed high levels of MCP-1. The addition of ω-3 fatty acids reduced MCP-1 expression with no effect on TNF-α. In addition, ω-3 fatty acids suppressed the upregulation of adipocyte MCP-1 that occurred when adipocytes were cocultured with macrophages. Thus, FO reduced adipose macrophages, increased capillaries, and reduced MCP-1 expression in insulin-resistant humans and in macrophages and adipocytes in vitro; however, there was no measureable effect on insulin sensitivity. Diabetes 62:1709–1717, 201

Safety, tolerability, and effectiveness of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin in combination with standard chemotherapy for patients with advanced, inoperable pancreatic adenocarcinoma: A phase 1b observational study

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Thus, there is an urgent need for safe and effective novel therapies. PDAC\u27s excessive reliance on glucose metabolism for its metabolic needs provides a target for metabolic therapy. Preclinical PDAC models have demonstrated that targeting the sodium-glucose co-transporter-2 (SGLT2) with dapagliflozin may be a novel strategy. Whether dapagliflozin is safe and efficacious in humans with PDAC is unclear. METHODS: We performed a phase 1b observational study (ClinicalTrials.gov ID NCT04542291; registered 09/09/2020) to test the safety and tolerability of dapagliflozin (5 mg p.o./day × 2 weeks escalated to 10 mg p.o./day × 6 weeks) added to standard Gemcitabine and nab-Paclitaxel (GnP) chemotherapy in patients with locally advanced and/or metastatic PDAC. Markers of efficacy including Response Evaluation Criteria in Solid Tumors (RECIST 1.1) response, CT-based volumetric body composition measurements, and plasma chemistries for measuring metabolism and tumor burden were also analyzed. RESULTS: Of 23 patients who were screened, 15 enrolled. One expired (due to complications from underlying disease), 2 dropped out (did not tolerate GnP chemotherapy) during the first 4 weeks, and 12 completed. There were no unexpected or serious adverse events with dapagliflozin. One patient was told to discontinue dapagliflozin after 6 weeks due to elevated ketones, although there were no clinical signs of ketoacidosis. Dapagliflozin compliance was 99.4%. Plasma glucagon increased significantly. Although abdominal muscle and fat volumes decreased; increased muscle-to-fat ratio correlated with better therapeutic response. After 8 weeks of treatment in the study, partial response (PR) to therapy was seen in 2 patients, stable disease (SD) in 9 patients, and progressive disease (PD) in 1 patient. After dapagliflozin discontinuation (and chemotherapy continuation), an additional 7 patients developed the progressive disease in the subsequent scans measured by increased lesion size as well as the development of new lesions. Quantitative imaging assessment was supported by plasma CA19-9 tumor marker measurements. CONCLUSIONS: Dapagliflozin is well-tolerated and was associated with high compliance in patients with advanced, inoperable PDAC. Overall favorable changes in tumor response and plasma biomarkers suggest it may have efficacy against PDAC, warranting further investigation