Childhood Trauma Effects on the Development of Personality and Mental Health

Childhood traumas are represented by events influencing a person's life affectingpersonality development and mental health. These traumas can be of several kinds, interpersonal andevents that happen outside on a wider scale. The effects of traumatic events are observed on physicalhealth, founding of relations, but also on mental health through the possibility of developing mentaldisorders. Young children pose an increased risk for traumatic events due to their dependence onparents or careers. But not all traumatic events affect more people, sometimes they come back tonormal life. But those who are severely affected by traumatic events may develop mental disorderssuch as post-traumatic stress or schizophrenia

Psychology and Art-Painting

Psychology and art seem to have two areas that do not have much in common but the twohave been combined in such a way that the psychology of art has appeared. A product of this psychologyis even art therapy, and painting is one of the most effective methods used in this therapy. Alsopsychology topics are played in many paintings over time, and this may be one of the reasons why weare attracted to certain paintings

Eating Disorders and the Media

Eating disorders are an increasingly common problem affecting younger people. These areof different types with effects and symptoms related to both the physical and the psychic side. Themedia is the main tool that leads to the spread of an image considered ideal which then induces a feelingof dissatisfaction among the population and a desire to reach that physical ideal. Thus, eating disordersarise from the desire to be someone else and to overcome an image of a fragile self

Time- and pH-dependent copper binding to Aβ(1-16) peptide: An electrospray ionization-mass spectrometric approach

An elevated concentration of copper ions in the brain of Alzheimer’s disease patients has been reported in many studies and might be associated with an increased aggregation of b-amyloid (Ab) peptides. In the present work, the interaction with copper ions of a model b-amyloid peptide, Ab(1–16), was investigated by electrospray ionization-mass spectrometry (ESI–MS) at two pH values, 7.4 and 6.6, as well as at various peptide: copper ion ratios in the first minutes after components mixing and time intervals. Our results indicated that copper ions specifically bound to Ab(1–16) peptide in solution and that the complex formation increased with time. Once formed in solution, Cu2?-Ab(1–16) complexes could easily be detected in the gas phase by ESI–MS. The pH shift from 7.4 to 6.6 only slightly influenced the Cu2? binding to Ab(1–16). No oligomerization of Ab(1–16) peptide was noticed in the first minutes of copper-peptide interaction

Microbiota: the missing link in the etiology of inflammatory bowel disease

Within its twisted and tight walls, where a hostile and arid environment prevails, the lumen of the digestive tract nests a true microuniverse called the microbiota. The existing relationship between humans and these microorganisms is one in which both benefit, creating a condition called Eubiosis. The dynamic relationship existing between the microbiota and the human body can be affected at various times, leading to an imbalance that may have important implications on health and generating a condition called Disbiosis. Recent studies have highlighted possible links between several diseases with incompletely elucidated etiology and disturbances of the microbiota. In this review we aim to analyze the existing relationship between the imbalances of the gastrointestinal flora and the etiopathogeny inflammatory bowel diseases, a group of diseases whose incidence has increased considerably in recent years

Microbiota: the missing link in the etiology of inflammatory bowel disease

Within its twisted and tight walls, where a hostile and arid environment prevails, the lumen of the digestive tract nests a true microuniverse called the microbiota. The existing relationship between humans and these microorganisms is one in which both benefit, creating a condition called Eubiosis. The dynamic relationship existing between the microbiota and the human body can be affected at various times, leading to an imbalance that may have important implications on health and generating a condition called Disbiosis. Recent studies have highlighted possible links between several diseases with incompletely elucidated etiology and disturbances of the microbiota. In this review we aim to analyze the existing relationship between the imbalances of the gastrointestinal flora and the etiopathogeny inflammatory bowel diseases, a group of diseases whose incidence has increased considerably in recent years

Alcoholic liver cirrhosis, more than a simple hepatic disease – A brief review of the risk factors associated with alcohol abuse

Liver cirrhosis is a significant public health problem, being an important cause of mortality and morbidity, responsible for approximately 1.8% of the total number of deaths in Europe. Chronic alcohol consumption is the most common cause of liver cirrhosis in developed countries. Europe has the highest level of alcohol consumption among all the global World Health Organisation (WHO) regions. In this paper, we briefly review major factors leading to excessive alcohol consumption in order to draw attention to the fact that alcoholic liver cirrhosis is more than a simple liver disease, and if those risk/causal factors can be prevented, the incidence of this disease could be reduced greatly. Although excessive alcohol consumption is regarded as the cause of alcoholic liver cirrhosis, the etiology is complex, involving multiple factors that act in synchrony, and which, if prevented, could greatly reduce the incidence of this disease. Children of addicts are likely to develop an alcohol-related mental disorder; however, there is no “gene for alcoholism”

Módosított GnRH-III-antraciklin biokonjugátumok daganat növekedést gátló hatásának tanulmányozása in vivo szubkután vs. ortotopikus rendszerekben

Az irányított/célzott tumorterápia nagyon perspektivikus eljárás a daganatok szelektív elpusztítására, ezáltal kiküszöbölhetők, vagy visszaszoríthatók a tumorellenes gyógyszerek mellékhatásai. Erre az eljárásra használhatók olyan konjugátumok, ahol a tumorellenes szer irányító molekulához (pl. peptid hormonok) van kapcsolva, melyeknek receptorai szelektíven csak a daganatsejteken jelennek meg, vagy azokon jóval nagyobb mennyiségben fordulnak elő, mint az egészséges sejteken. Az in vitro citosztázis/citotoxicitás vizsgálatok általában nem nyújtanak elég információt arra nézve, hogy az előállított konjugátum hatékonyabb-e a szabad hatóanyagnál, erre csak az in vivo vizsgálatokból lehet következtetni. Nagyon fontos azonban a hamis pozitív eredmények kiszűrése érdekében a megfelelő tumormodell megválasztása. Munkánk során egy gonadotropin-releasing hormon analóg a GnRH-III variánsok daunorubicin konjugátumainak daganatnövekedést gátló hatását vizsgáltuk egerekbe szubkután, illetve ortotopikusan beültetett tumorokon. A környezetétől izolált szubkután tumormodell a valóságtól eltérő eredményeket adhat a molekulák tumornövekedést gátló hatásának vizsgálatára. Az ortotopikus rendszerrel jobban modellezhető az anatómiailag és klinikailag megfelelő állapot. Ezért célszerű a későbbiekben az általunk kialakított ortotopikus vastagbél tumormodellt alkalmazni az irányított daganatterápiára előállított vegyületek szűrésére

Alcoholic liver cirrhosis, more than a simple hepatic disease – A brief review of the risk factors associated with alcohol abuse

Liver cirrhosis is a significant public health problem, being an important cause of mortality and morbidity, responsible for approximately 1.8% of the total number of deaths in Europe. Chronic alcohol consumption is the most common cause of liver cirrhosis in developed countries. Europe has the highest level of alcohol consumption among all the global World Health Organisation (WHO) regions. In this paper, we briefly review major factors leading to excessive alcohol consumption in order to draw attention to the fact that alcoholic liver cirrhosis is more than a simple liver disease, and if those risk/causal factors can be prevented, the incidence of this disease could be reduced greatly. Although excessive alcohol consumption is regarded as the cause of alcoholic liver cirrhosis, the etiology is complex, involving multiple factors that act in synchrony, and which, if prevented, could greatly reduce the incidence of this disease. Children of addicts are likely to develop an alcohol-related mental disorder; however, there is no “gene for alcoholism”