22 research outputs found

    Real-Time Analysis-Synthesis and Intelligibility of Talking Faces

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    Analytic measurement of visual parameters relevant to the labial production of speech as well as real-time 3D computer animated models of the lips and of the face have been implemented on two coupled computers, so that synthetic lips alone or a whole facial model can mimic on line (or play back) the actual gestures of a natural speaker. The geometric measurements performed on the speaker's lips and jaw are made through image processing of the front and profile view of the speaker's face. Data are transmitted to a display computer through a control interface which delivers the proper parameters to control the animation of the 3D models. The lip model uses five control parameters and the facial model uses one extra one: jaw lowering. At present, the tongue is not controlled. We here present the realtime techniques used for analysis, animation of the 3D models, and synchronization of the two processes. Finally, we evaluate the bimodal intelligibility of speech under five levels of acousti..

    Microbiome and Metabolome Variation as Indicator of Social Stress in Female Prairie Voles

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    Social isolation is detrimental to the health of social mammals inducing neurochemical and hormonal changes related to depression and anxiety, as well as impairments of cardiovascular and immune functioning. Likewise, perceptions of loneliness are increasingly recognized as detrimental to human psychological well-being, cognitive functioning, and physical health. Few studies, however, have examined the impact of social isolation on the intestinal microbiome and metabolome. To better understand the impact of social isolation on these systems, intestinal microbiota, and the systemic impact via the gut–brain axis, we employed prairie voles. Physiological stress on female prairie voles (n = 22) either with a same-sex sibling (n = 11) or in isolation (n = 11) for four weeks demonstrated behavioral indicators of increased anxiety and depression in isolated voles (p ≤ 0.01). Bacterial DNA from fecal and colon samples, collected at five time points (T0–4), were sequenced for all nine hypervariable regions of the 16S rRNA gene. Microbiome analyses revealed several differences in gut communities of paired and isolated voles with greater differences at T4. Notably, several taxa associated with host health including Anaerostipes and Lactobacillaceae were more prevalent in paired voles, whereas several taxa associated with known pathogens (e.g., Staphylococcaceae and Enterococcus) or disease were elevated in isolated animals. Similarly, metabolome analyses suggested isolated voles, when compared to paired animals, exhibited differences in metabolites associated with diabetes and colitis. These findings further contribute to our understanding of the harmful effects of social isolation, which cause perturbations in the gut microbiome and serum metabolites
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