Alien Registration- Gauthier, Marie (Auburn, Androscoggin County)

https://digitalmaine.com/alien_docs/31002/thumbnail.jp

La philosophie dès le primaire ! Quelques difficultés à surmonter

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L'observation en psychosomatique

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Génération de Tests pour les Systèmes Temps-Réel à partir de Modèles SysML: Contexte, Motivations et Objectifs

National audienceThis paper presents an approach of Model-Based Testing for real-time and embedded systems using SysML. This work is based on an existing approach that has been proposed during the VETESS project. This approach aims to generate tests for embedded systems. In this paper, we identify areas of improvement, which permit to evolve the initial approach by taking into account the real-time aspects. These areas, which are presented in the form of research questions, aim to propose an automated Model-Based-Testing toolchain for real-time and embedded systems. Finally, the proposed approach is briefly included in the related works

Restoring peatland plant communities on mineral well pads

Les tourbières sont largement représentées dans la région boréale de l'Alberta, mais peu est connu sur la restauration de plates-formes de forage localisées en milieux tourbeux. Deux expériences de terrain ont testées la provenance du matériel végétal (bog, écotone bog-peupleraie, fen dominé par saules-Cyperacées, riche fen arbustif, riche fen forestier) à réintroduire sur différents substrats (sciure, loam argileux, mélange sciure-loam, tourbe, microtopographie) sur d’anciennes plates-formes. Nos résultats montrent que les communautés de tourbières peuvent s’établir sur un sol minéral après transfert d’une couche muscinale. Le type de communauté végétale où les propagules sont récoltées est un facteur déterminant au succès des bryophytes à s’établir. Un amendement en tourbe facilite l’établissement des plantes. La technique de transfert de mousse est une approche prometteuse pour la restauration de fens sur plateformes pétrolières. Nous recommandons une mise à l’échelle pour tester la validité de ces méthodes de réintroduction de végétation de manière mécanisée.Peatlands are largely represented in the boreal region of Alberta but little is known about their restoration on well sites. The goal of this study is to compare plant communities and substrates in order to recover peatland vegetation. Two field experiments tested which plant communities (bog, bog-aspen ecotone, willow-sedge fen, shrubby rich fen, treed rich fen) would best regenerate on different substrate (sawdust, clay loam, mix sawdust-clay, peat, surface roughness). We found that peatland communities can establish on mineral soil after propagules transfer using the moss layer transfer technique (MLTT). The choice of plant community, where the propagules are harvested is key to bryophytes establishment. Peat amendment facilitated the plants establishment. The MLTT is a promising approach to restore fen plants on well sites. We recommend a scale-up experiment for a whole well site to test the validity of MLTT within pad removal techniques

Biomonitoring of the genotoxic potential of aqueous extracts of soils and bottom ash resulting from municipal solid waste incineration, using the comet and micronucleus tests on amphibian (Xenopus laevis) larvae and bacterial assays (MutatoxR and Ames tests)

The management of contaminated soils and wastes is a matter of considerable human concern. The present study evaluates the genotoxic potential of aqueous extracts of two soils (leachates) and of bottom ash resulting from municipal solid waste incineration (MSWIBA percolate), using amphibian larvae (Xenopus laevis). Soil A was contaminated by residues of solvents and metals and Soil B by polycyclic aromatic hydrocarbons and metals. MSWIBA was predominantly contaminated by metals. Two genotoxic endpoints were analysed in circulating erythrocytes taken from larvae: clastogenic and/or aneugenic effects (micronucleus induction) after 12 days of exposure and DNA-strand-breaking potency (comet assay) after 1 and 12 days of exposure. In addition, in vitro bacterial assays (MutatoxR and Ames tests) were carried out and the results were compared with those of the amphibian test. Physicochemical analyses were also taken into account. Results obtained with the amphibians established the genotoxicity of the aqueous extracts and the comet assay revealed that they were genotoxic from the first day of exposure. The latter test could thus be considered as a genotoxicity-screening tool. Although genotoxicity persisted after 12 days’ exposure, DNA damage decreased overall between days 1 and 12 in the MSWIBA percolate, in contrast to the soil leachates. Bacterial tests detected genotoxicity only for the leachate of soil A (Mutatox). The results confirm the ecotoxicological relevance of the amphibian model and underscore the importance of bioassays, as a complement to physicochemical data, for risk evaluation

Integrating AADL and FMI to Extend Virtual Integration Capability

Virtual Integration Capability is paramount to perform early validation of Cyber Physical Systems. The objective is to guide the systems engineer so as to ensure that the system under design meets multiple criteria through high-fidelity simulation. In this paper, we present an integration scheme that leverages the FMI (Functional Mock-Up interface) standard and the AADL architecture description language. Their combination allows for validation of systems combining embedded platform captured by the AADL, and FMI components that represent physical elements, either mechanical parts, or the environment. We present one approach, and demonstrator case studies

Méthodes orientées agent et multi-agent

http://www.emse.fr/~picard/publications/bernon09industrie.pdfNational audienceLes systèmes multi-agents (SMA) ont montré leur pertinence pour la conception d'applications distribuées (logiquement ou physiquement), complexes et robustes. Le concept d'agent est aujourd'hui plus qu'une technologie efficace, il représente un nouveau paradigme pour le développement de logiciels dans lesquels l'agent est un logiciel autonome qui a un objectif, évolue dans un environnement et interagit avec d'autres agents au moyen de langages et de protocoles (voir le chapitre 1 " Introduction aux systèmes multi-agents "). Souvent, l'agent est considéré comme un objet " intelligent " ou comme un niveau d'abstraction au-dessus des objets et des composants (voir le chapitre 5 " Composants logiciels et systèmes multi-agents "). Les méthodes de développement orientées objet - au vu des différences entre les objets et les agents - ne sont pas directement applicables au développement de SMA. Il est alors devenu nécessaire d'étendre ou de développer de nouveaux modèles, de nouvelles méthodologies et de nouveaux outils adaptés au concept d'agent

Proteomic Approaches to Dissect Host SUMOylation during Innate Antiviral Immune Responses

SUMOylation is a highly dynamic ubiquitin-like post-translational modification that is essential for cells to respond to and resolve various genotoxic and proteotoxic stresses. Virus infections also constitute a considerable stress scenario for cells, and recent research has started to uncover the diverse roles of SUMOylation in regulating virus replication, not least by impacting antiviral defenses. Here, we review some of the key findings of this virus-host interplay, and discuss the increasingly important contribution that large-scale, unbiased, proteomic methodologies are making to discoveries in this field. We highlight the latest proteomic technologies that have been specifically developed to understand SUMOylation dynamics in response to cellular stresses, and comment on how these techniques might be best applied to dissect the biology of SUMOylation during innate immunity. Furthermore, we showcase a selection of studies that have already used SUMO proteomics to reveal novel aspects of host innate defense against viruses, such as functional cross-talk between SUMO proteins and other ubiquitin-like modifiers, viral antagonism of SUMO-modified antiviral restriction factors, and an infection-triggered SUMO-switch that releases endogenous retroelement RNAs to stimulate antiviral interferon responses. Future research in this area has the potential to provide new and diverse mechanistic insights into host immune defenses