highRES-Europe: The high spatial and temporal Resolution Electricity System model for Europe

The high spatial and temporal resolution electricity system model, highRES, is used to design cost-effective, flexible and weather resilient electricity systems for Great Britain and Europe. The model is specifically designed to analyse the effects of high shares of variable renewables and explore integration/flexibility options. As the proportion of renewables in electricity generation increases, there will be increasing imbalances between electricity demand and supply. highRES is a high-resolution electricity system model that simultaneously considers infrastructure planning (investment) and operational (dispatch) decisions to identify the most cost-effective strategies to cope with growing shares of intermittent renewables. It does this by comparing and trading off potential options to integrate renewables into the system including the extension of the transmission grid, interconnection with other countries, building flexible generation (e.g. gas power stations), renewable curtailment and energy storage. highRES is written in GAMS and its objective is to minimise power system investment and operational costs to meet hourly demand, subject to a number of unit and system constraints. It can model a variety of technical characteristics of thermal generators (e.g. ramping restrictions, minimum stable generation, startup costs, minimum up and down times) depending on the requirements of the research question, their CO2 emissions, and the technical characteristics of a variety of energy storage options. The transmission grid is represented using a linear transport model

Distinctive and pervasive alterations in aqueous humor protein composition following different types of glaucoma surgery

PURPOSE: To investigate whether specific glaucoma surgeries are associated with differences in aqueous humor protein concentrations compared to eyes without filters. METHODS: In this cross-sectional study, aqueous humor samples were prospectively collected from control subjects who underwent routine cataract surgery (n=14) and from patients who had different glaucoma filters: Baerveldt aqueous shunt (n=6), Ahmed aqueous shunt (n=6), trabeculectomy (n=5), and Ex-Press trabeculectomy (n=3). Total protein concentrations were determined with Bradford assay. Tryptic digests were analyzed with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Proteins were identified with high confidence using stringent criteria and were quantitatively compared with a label-free platform. Relative protein quantities were compared across groups with ANOVA. Post hoc pair-wise comparisons were adjusted for multiple comparisons. RESULTS: Compared to the control eyes, the aqueous humor protein concentration was increased approximately tenfold in the Ahmed and Baerveldt eyes and fivefold in the trabeculectomy and Ex-Press eyes. Overall, 718 unique proteins, splice variants, or isoforms were identified. No differences in the protein concentrations were detected between the Baerveldt and Ahmed groups. Likewise, the trabeculectomy and Ex-Press groups were remarkably similar. Therefore, the aqueous shunt groups were pooled, and the trabeculectomy groups were pooled for a three-way comparison with the controls. More than 500 proteins differed significantly in relative abundance (ANOVA p<0.01) among the control, aqueous shunt, and trabeculectomy groups. Functional analyses suggested these alterations in relative protein abundance affected dozens of signaling pathways. CONCLUSIONS: Different glaucoma surgical procedures were associated with marked increases in the aqueous humor protein concentration and distinctive changes in the relative abundance of numerous proteins involved in multiple signaling pathways

Rac Activation Induces NADPH Oxidase Activity in Transgenic COSphox Cells and Level of Superoxide Production is Exchange Factor-Dependent

Transient expression of constitutively active Rac1 derivatives, (G12V) or (Q61L), was sufficient to induce phagocyte NADPH oxidase activity in a COS-7 cell model in which human cDNAs for essential oxidase components, gp91phox, p22phox, p47phox, and p67phox, were expressed as stable transgenes. Expression of constitutively active Rac1 in “COSphox” cells induced translocation of p47phox and p67phox to the membrane. Furthermore, translocation of p47phox was induced in the absence of p67phox expression, even though Rac does not directly bind p47phox. Rac effector domain point substitutions (A27K, G30S, D38A, Y40C), which can selectively eliminate interaction with different effector proteins, impaired Rac1V12-induced superoxide production. Activation of endogenous Rac1 by expression of constitutively active Rac-guanine nucleotide exchange factor (GEF) derivatives was sufficient to induce high level NADPH oxidase activity in COSphox cells. The constitutively active form of the hematopoietic-specific GEF, Vav1, was the most effective at activating superoxide production, despite detection of higher levels of Rac1-GTP upon expression of constitutively active Vav2 or Tiam1 derivatives. These data suggest that Rac can play a dual role in NADPH oxidase activation, both by directly participating in the oxidase complex and by activating signaling events leading to oxidase assembly, and that Vav1 may be the physiologically relevant GEF responsible for activating this Rac-regulated complex

The direct interconnection of the UK and Nordic power market – Impact on social welfare and renewable energy integration

United Kingdom and the Nordic power market have plans to interlink directly through a sub-sea power transmission line in The North Sea. Such power market couplings have complicated implications for the interconnected energy systems and for different agents in the common power market. We analyse this case by modelling the hourly operation of the Nordic-UK power market coupling, considering the local district heating (DH) system in each country as well. According to the results, after the operation of the new interconnection between Norway and the UK (North Sea Link), the overall socio-economic benefits (social welfare) in the region will likely improve by 220–230 million euro per year, without considering the cost of the interconnector itself. The UK-Nordic market coupling enhances the flexibility of the UK power system in wind integration, irrespective of the share of wind in the Nordic countries. However, increasing wind capacity in the UK will diminish the expected economic benefits of the link. The merit order effect of wind integration in the UK will reduce the price gap between UK and Norway, and so the congestion income of the link in many hours a year when the link is congested from Norway towards the UK