Proyecto llapa app

En el presente trabajo de investigación, se ha desarrollado la validación del modelo de negocio de la creación del aplicativo Llapa. Esta es una plataforma de dropshipping que básicamente es una tienda online que se encargará de ser un intermediario para que los emprendedores peruanos puedan ofrecer y vender sus productos y servicios. Este aplicativo se encuentra dirigido a dos segmentos, el primero es a hombres y mujeres entre los 18 y 30 años, que residen en Lima Metropolitana y pertenecen a los niveles socioeconómicos A y B: el segundo segmento son los emprendedores peruanos que deseen vender sus productos y servicios de manera online en Lima Metropolitana. Tras la coyuntura actual de la pandemia se ha observado un crecimiento del comercio electrónico en el país, lo que se ha podido comprobar luego de la revisión de fuentes primarias y secundarias, así como también de las entrevistas realizadas a lo largo de toda la investigación a expertos y usuarios. Por lo cual, consideramos que Llapa es un proyecto innovador que no cuenta con competidores que ofrezcan la misma oferta que se encuentra relacionada a brindar la oportunidad a emprendedores de nuestro país en dar a conocer sus negocios en diferentes categorías como alimentos y bebidas, textiles, aparatos electrónicos, belleza bienestar y salud, libros, hogar y muebles, juguetes y hobbies. Se puede afirmar que la propuesta de valor del modelo de negocio es viable en el mercado limeño. Por último, se procedió a realizar el plan financiero del proyecto para evaluar su viabilidad, obteniendo como resultados que será necesario una inversión inicial, se tendrán costos operativos, gastos administrativos y de ventas. Además, se realizó la estimación de las ventas en base al concierge y fuentes secundarias. Con todo lo anteriormente mencionado se puede concluir que Llapa es un proyecto viable, ya que presentó un VAN positivo de 2,790,443 soles y una TIR de 35%.In this research work, the validation of the business model for the creation of the Llapa application has been developed. This is a dropshipping platform that is basically an online store that will be in charge of being an intermediary so that Peruvian entrepreneurs can offer and sell their products and services. This application is aimed at two segments, the first is for men and women between 18 and 30 years old, who reside in Metropolitan Lima and belong to socioeconomic levels A and B: the second segment is Peruvian entrepreneurs who wish to sell their products and online services in Metropolitan Lima. After the current situation of the pandemic, a growth in electronic commerce has been observed in the country, which has been verified after the review of primary and secondary sources, as well as the interviews carried out throughout the investigation to experts and users. Therefore, we consider that Llapa is an innovative project that does not have competitors that offer the same offer that is related to providing the opportunity to entrepreneurs in our country to publicize their businesses in different categories such as food and beverages, textiles, electronic devices, beauty, wellness and health, books, home and furniture, toys and hobbies. It can be said that the value proposition of the business model is viable in the Lima market. Finally, the financial plan of the project was carried out to evaluate its viability, obtaining as results that an initial investment will be necessary, there will be operating costs, administrative and sales expenses. In addition, the sales estimate was made based on the concierge and secondary sources. With all the aforementioned, it can be concluded that Llapa is a viable project, since it presented a positive NPV of 2,790,443 soles and an IRR of 35%.Trabajo de investigació

Effects Of Modafinil And Bromazepam On Decision-Making: A P300 Analysis

Drug influence on the decision making process has been scarcely studied. Researchers have driven the hypothesis that drugs might cause interference on cortical circuits. The aim of the present study is to evaluate the electrophysiological and behavioral changes occurring in the P300 after ingestion of modafinil (200mg), bromazepam (6mg) and placebo in healthy subjects exposed to a sensorimotor task based on the oddball paradigm. The sample for this study consisted of 10 subjects of both sexes, with ages ranging between 20 and 45, who were submitted to a quantitative electroencephalography. The experimental procedure was carried out in three visits, before and after drug ingestion. The results demonstrated a significant increase in the P300 latency and amplitude for the target condition, when compared to the non-target condition, for all analyzed electrodes. No significant difference was found for group or moment. A statistically significant difference was found for the group variable in the behavioral analysis. Such results suggest that the P300 is a measure, which is not sensitive to drug ingestion. On the other hand, the measure presented certain level of sensitivity when the subjects faced two different conditions in the decision making process orientation

Lupus en Argentina. Pacientes no respondedores al tratamiento estándar y belimumab como posible opción. Datos del registro RELESSAR

Introducción: el lupus es una enfermedad compleja y varias veces de difícil abordaje. Alcanzar la remisión es uno de los objetivos, incorporando opciones terapéuticas. Objetivos: describir las características generales de los pacientes según el estado de la enfermedad y el uso de belimumab. Materiales y métodos: estudio de corte transversal, registro RELESSAR. Se definió el estado de la enfermedad como: remisión: SLEDAI=0 y sin corticoides; baja actividad de la enfermedad: SLEDAI >0 y ≤4 y sin corticoides; control no óptimo: SLEDAI >4 y cualquier dosis de corticoides. Resultados: se incluyeron 1.277 pacientes, 23,4% en remisión, 12,6% en baja actividad y 63,8% con control no óptimo. En este último grupo eran más jóvenes y con menor duración de la enfermedad; presentaban mayores índices de actividad y cronicidad, y mayor empleo de inmunosupresores. Solo el 22,3% de los pacientes con criterio potencial de uso de belimumab (lupus eritematoso sistémico activo a pesar del tratamiento estándar) lo recibía en ese momento. Las variables asociadas a hospitalizaciones fueron: terapia con corticoides, ciclofosfamida y mayor SLICC. Conclusiones: se refleja la complejidad del manejo de estos pacientes y se visualizan aspectos estructurales como la desigualdad. El uso del belimumab resultaría beneficioso en los pacientes seleccionados

Drogas dopaminérgicas alteram a coerência beta durante a imagética motora e a execução motora em adultos saudáveis

BACKGROUND: Motor Imagery (MI) represents the cognitive component of the movement and recruits dopaminergic systems. OBJECTIVE: To investigate the role of dopaminergic system through the action of methylphenidate and risperidone over beta coherence during execution, action observation and motor imagery. METHODS: Electroencephalography (EEG) data were recorded before and after the substance intake. For statistical analysis, a three-way ANOVA was used to identify changes in beta coherence induced by the group, task and the moment variables. Statistical significance was set at p≤0.007. RESULTS: We found a main effect for group for C3/CZ, and a main effect for task for CZ/C4 pairs of electrodes. Furthermore, significant differences were found in the post-drug administration between groups for C3/CZ pair of electrodes, and between task for C4/CZ pair of electrodes. CONCLUSION: The administration of methylphenidate and risperidone was able to produce electrocortical changes of the cortical central regions, even when featuring antagonistic effects on the dopaminergic pathways. Moreover, the execution task allowed beta-band modulation increase

Alpha power oscillation in the frontal cortex under Bromazepam and Modafinil effects

ABSTRACTObjective Our aim was to investigate and compare the neuromodulatory effects of bromazepam (6 mg) and modafinil (200 mg) during a sensorimotor task analyzing the changes produced in the absolute alpha power.Method The sample was composed of 15 healthy individuals exposed to three experimental conditions: placebo, modafinil and bromazepam. EEG data were recorded before, during and after the execution of the task. A three-way ANOVA was applied, in order to compare the absolute alpha power among the factors: Group (control, bromazepam and modafinil) Condition (Pre and Post-drug ingestion) and Moment (pre and post-stimulus).Results Interaction was found between the group and condition factors for Fp1, F4 and F3. We observed a main effect of moment and condition for the Fp2, F8 and Fz electrodes.Conclusion We concluded that drugs may interfere in sensorimotor processes, such as in the performance of tasks carried out in an unpredictable scenario

The effects of bromazepam over the central and frontal areas during a motor task: an EEG study

The present study investigates the influence of bromazepam while executing a motor task. Specifically, we intend to analyze the changes in alpha absolute power under two experimental conditions, bromazepam and placebo. We also included analyses of theta and beta frequencies. We collected electroencephalographic data before, during, and after motor task execution. We used a Two Way ANOVA to investigate the condition (PL × Br6 mg) and moment (pre and post) variables for the following electrodes: Fp1, Fp2, F7, F3, Fz, F4, F8, C3, CZ and C4. We found a main effect for condition on the electrodes FP1, F7, F3, Fz, F4, C3 and CZ, for alpha and beta bands. For beta band we also found a main effect for condition on the electrodes Fp2, F8 and C4; for theta band we identified a main effect for condition on C3, Cz and C4 electrodes. This finding suggests that the motor task did not have any influence on the electrocortical activity in alpha, and that the existing modifications were a consequence due merely to the drug use. Despite its anxiolytic and sedative action, bromazepam did not show any significant changes when the individuals executed a finger extension motor task

Neurophysiological evidence of compensatory brain mechanisms in early-stage multiple sclerosis

Multiple sclerosis (MS) is a chronic central nervous system disorder characterized by white matter inflammation, demyelination and neurodegeneration. Although cognitive dysfunction is a common manifestation, it may go unnoticed in recently-diagnosed patients. Prior studies suggest MS patients develop compensatory mechanisms potentially involving enhanced performance monitoring. Here we assessed the performance monitoring system in early-stage MS patients using the error-related negativity (ERN), an event-related brain potential (ERP) observed following behavioral errors. Twenty-seven early-stage MS patients and 31 controls were neuropsychologically assessed. Electroencephalography recordings were obtained while participants performed: a) a stop task and b) an auditory oddball task. Behavior and ERP measures were assessed. No differences in performance were found between groups in most neuropsychological tests or in behavior or ERP components in the auditory oddball task. However, the amplitude of the ERN associated with stop errors in the stop task was significantly higher in patients. ERN amplitude correlated positively with scores on the Expanded Disability Status Scale and the Multiple Sclerosis Severity Score, and negatively with the time since last relapse. Patients showed higher neuronal recruitment in tasks involving performance monitoring. Results suggest the development of compensatory brain mechanisms in early-stage MS and reflect the sensitivity of the ERN to detect these changes

Revisiting the species status of Pecari maximus van Roosmalen et al., 2007 (Mammalia) from the Brazilian Amazon

Volume: 60Start Page: 95End Page: 10