The effects of local systems on the international de-localisation of production.The case of made in Italy

The paper examines the fragmentation of production from the view-point of industrialised countries. From this perspective, the following questions are addressed: how do local systems evolve in the process of de-localisation of productions? Which are the short term and long term effects to be expected? Can we interpret these processes under the light of changing specialization of economic systems, necessarily associated with gains from trade? Evidence is provided on the internationalization of manufacturing activities that are commonly identified as “made in Italy”, with specific reference to the textile and footwear industries. The focus will be on the re-organization of economic activities at the level of local systems specialized in these industries, rather than on individual firms; on the whole set of international operations involved in this process, regardless of the legal form adopted (FDIs, import-export, cooperative agreements and licensing); and on how changes in the international organisation of production in these industries are associated with changes in the economic performances within these industries as well as in related sectors, such as service industries.Foreign Direct Investments,Import-export cooperative agreements, Licensing.

Libya between History and Revolution: Resilience, New Opportunities and Challenges for the Berbers

[Italiano]: La conferenza internazionale Libya between History and Revolution: Resilience, new opportunities and new challenges for the Berbers svolta all’Università di Napoli "L’Orientale" dal 15 al 17 gennaio 2018, è stata dedicata alla storia contemporanea della Libia. L’obiettivo è stato di comprendere una realtà che è per la maggior parte poco nota alla stragrande maggioranza del pubblico italiano, e questo nonostante la colonizzazione, le sue conseguenze e le relazioni che sono sempre esistite tra i due paesi. Al contrario, prima la promozione della logica dei colonizzatori, poi la retorica del regime di Gheddafi e infine le attuali rappresentazioni strettamente legate alle emergenze terroristiche, all’immigrazione e alla guerra all’interno e all’esterno del mondo islamico, sono tutte ben note e documentate. Questo volume Libya between History and Revolution: Resilience, New Opportunities and Challenges for the Berbers comprende articoli degli studiosi italiani e stranieri che hanno preso parte alla conferenza e mirano a fornire approfondimenti su una serie di questioni cruciali che sono state ereditate dalla storia coloniale fino alle rivolte del 2011; in particolare il ruolo dei berberi in Libia, attraverso il prisma delle nuove opportunità e le sfide che devono affrontare oggi e che sono stati discussi durante la conferenza internazionale di tre giorni ./[English]: The International Conference Libya between History and Revolution: Resilience and New Narrations of Berber Identity convened at the University of Naples “L’Orientale” from the 15th to the 17th January 2018, was dedicated to the contemporary history of Libya. Its purpose was to understand a reality that is for the most part little known to the vast majority of the Italian public, and this despite colonization, its consequences, and the relations that have always existed between the two countries. Conversely, first the promotion of the colonizers’ rationale, then the rhetoric of Qadhafi’s regime, and finally the current representations closely related to terrorist emergencies, immigration, and war within and outside the Islamic world, are all well-known and documented. This volume Libya between History and Revolution: Resilience, New Opportunities and Challenges for the Berbers brings together papers by the scholars (from both Italy and abroad) who took part in the conference. The aim of this collection is to provide insights into a range of crucial issues that affected the country as a consequence of its colonial history and informed the uprisings of 2011; the volume looks in particular at the role of the Berbers in Libya through the prism of the new opportunities and challenges that face them today and which were discussed during the three-day international conference

Post-lacustrine evolution of a tectonically-controlled intermontane basin: Drainage network analysis of the Mercure basin, southern Italy

Topographic analysis, drainage network morphometry, river profile analysis, and spatial distribution of fluvio-lacustrine terraces have been used to reconstruct the drainage network evolution in the Mercure River basin, a large intermontane tectonic basin of the axial zone of southern Apennines. Morphotectonic evolution of the study area is mainly controlled by poly-kinematics high-angle WNW-ESE and NE-SW faults, which promoted the development of a complex landscape with relict landscapes and/or low-relief erosional surfaces that occurred in a staircase arrangement at the top of the landscapes or at higher altitudes than the basin infill. The creation of the accommodation space for the deposition of the thick basin infill was related to an important tectonic phase of block-faulting along N120°-trending normal faults, which occurred in the final part of the Lower Pleistocene. Such an evolution strongly controls the longitudinal profile forms of channels draining the northern sector of the study area, which are featured by a well-developed concave-up segment in river profiles of these channels between an upward trait with lower values of channel steepness and the trace of the master fault. River profiles in north-western and south-east sectors of the Mercure River basin exhibit clear knickpoints at altitudes comparable with those of the superimposed orders of relict landscapes related to the initial formation of the tectonic basin and the subsequent evolution of the endorheic basin, with a post-lacustrine geomorphological evolution of the drainage network that is controlled by fluvial incision occurring at rates comparable than those reconstructed by independent morphotectonic markers. The erosion of the threshold of the endorheic basin occurring during the base-level fall of the MIS 12 promoted a dramatic base-level fall of about 150 m, which corresponds to a mean incision rate of about 0.35 mm/yr. Post-lacustrine evolution of the Mercure basin strongly controls the morphometric features of the drainage network, which preserves a centripetal pattern with several planimetric anomalies such as counterflow and high-angle confluences, local-scale fluvial capture phenomena and drainage divide migrations

Can a fully integrated approach enclose the drainage system design and the flood risk analysis?

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CDK/CCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity

The regulation of cell growth and division occurs in an accurate sequential manner. It is dictated by the accumulation of cyclins (CCNs) and cyclin-dependent kinases (CDKs) complexes and degradation of CCNs. In human tumors, instead, the cell cycle is deregulated, causing absence of differentiation and aberrant cell growth. Oncogenic alterations of CCNs, CDKs, and CDKIs have been reported in more than 90% of human cancers, and the most frequent are those related to the G1 phase. Several molecular mechanisms, including gene overexpression, chromosomal translocations, point mutations, insertions and deletions, missense and frame shift mutation, splicing, or methylation, may be responsible for these alterations. The cell cycle regulators are involved in tumor progression given their association with cancers characterized by higher incidence of relapses and chemotherapy resistance. In the last decade anticancer drug researches focused on new compounds, able to target molecules related to changes in genes associated with tumor status. Recently, the studies have focused on the restoration of cell cycle control modulating molecular targets involved in cancer-cell alterations. This paper aims to correlate alterations of cell cycle regulators with human cancers and therapeutic responsivity

effects of a new human recombinant mnsod in the treatment of photoaging and actinic keratosis

Physiological processes, as aerobic metabolism and inflammatory response, generate reactive oxygen species (ROS) that may induce cellular injury when their amount is increased and antioxidant defense mechanisms are overwhelmed. Also, ROS are generated following UV skin irradiation able to deplete the natural antioxidant defenses in the skin. The increase in exposure to UV may lead to photoaging and precancerous skin lesions (actinic keratosis). New antioxidant strategies in the prevention and therapy of skin lesions are urgently needed. In this study, we evaluated the antioxidant efficacy of a recombinant form of human manganese superoxide dismutase able to inhibit reactive oxygen species production in some patients affected by severe photoaging and actinic keratosis

PNA-based graphene oxide/porous silicon hybrid biosensor: towards a label-free optical assay for Brugada Syndrome

Peptide nucleic acid (PNA) is a synthetic DNA mimic that outperforms the properties of traditional oligonucleotides (ONs). On account of its outstanding features, such as remarkable binding affinity towards complementary DNA or RNA as well as high thermal and chemical stability, PNA has been proposed as a valuable alternative to the ON probe in gene-sensor design. In this study, a hybrid transducer made-up of graphene oxide (GO) nano-sheets covalently grafted onto a porous silicon (PSi) matrix has been investigated for the early detection of a genetic cardiac disorder, the Brugada syndrome (BS). A functionalization strategy towards the realization of a potential PNA-based device is described. A peptide nucleic acid (PNA), able to detect the SCN5A associated with the BS has been properly synthesized and used as a bioprobe for the realization of a proof-of-concept label-free optical PNA-biosensor. PSi reflectance and GO photoluminescence (PL) signals were simultaneously exploited for the monitoring of the device functionalization and response

A new hexapeptide from the leader peptide of rMnSOD enters cells through the oestrogen receptor to deliver therapeutic molecules

A 24-amino acid leader peptide of a new human recombinant manganese superoxide dismutase can enter cells and carry molecules. Here, we demonstrated that six of the 24 amino acids penetrate cells through a particular gate represented by a specific amino acid sequence of the oestrogen receptor (ER). We analysed the internalization of the synthetic hexapeptide and the cytotoxic activity of the hexapeptide conjugated to cisplatin on a cell line panel. In most cell lines, the hexapeptide delivered an amount of cisplatin that was 2 to 8 times greater than that released by cisplatin when the drug was used alone. This increased delivery increases the therapeutic index of cisplatin and reduces side effects caused by a high dosage or long-term treatment times. We may consider this hexapeptide a new molecular carrier to deliver molecules with therapeutic activity into ER+ cells for diagnostic purposes and clinical or immune therapy