Ocena stopnia deficytu w zakresie podstawowych czynności dnia codziennego

Introduction. The aging of the organism is a dynamic and irreversible process of our organism. The possibility of exercising self-care, i.e. performing activities on one's own, such as walking, eating, controlling physiological needs and maintaining personal hygiene, should be equated with independence. The aim.  The aim of the study is to assess the deficit in basic everyday activities among people covered by long-term residential care. Materials and methods. The tool in my research work is the analysis of patients' medical records in terms of the Barthel scale. Results. The analysis of the obtained own research allowed for the formulation of the following results: Gender has a significant impact on the mobility of the examined people. Age has a significant influence on the possibility of washing and bathing the whole body. There is a significant relationship between where older people live and the ability to use the toilet. Conclusions. The level of stress, measured one year after the outbreak of the pandemic, does not indicate excessive stress, but the adaptation phase in a crisis situation. The effects of working under chronic stress may not be visible until the future. Further stress monitoring and providing nursing staff with psychological support is highly advisable.Wstęp. Starzenie się organizmu jest dynamicznym i nieodwracalnym procesem naszego organizmu.  Możliwość sprawowania samoopieki czyli wykonanie we własnym zakresie czynności takich jak poruszanie się, odżywianie, kontrolowanie potrzeb fizjologicznych i utrzymanie higieny osobistej należy utożsamić z niezależnością. Cel. Celem pracy jest ocena stopnia deficytu  w zakresie podstawowych czynności dnia codziennego wśród osób objętych opieką długoterminową  stacjonarną. Materiał i metody. W mojej pracy badawczej narzędziem jest analiza dokumentacji medycznej pacjentów w zakresie skali Barthel. Wyniki. Analiza uzyskanych badań własnych pozwoliła na sformułowanie następujących wyników: Płeć ma istotny wpływ  na możliwość  poruszania się badanych osób. Wiek ma znaczny wpływ na możliwość mycia, kąpieli całego ciała. Istnieje istotna zależność pomiędzy miejscem pobytu osób starszych a możliwością korzystania z toalety. Wnioski. Płeć ma wpływ  na możliwość  poruszania się badanych osób. Wiek ma wpływ na możliwość mycia, kąpieli całego ciała. Istnieje zależność pomiędzy miejscem pobytu osób starszych a możliwością korzystania z toalety

Phosphorylated ERK5/BMK1 transiently accumulates within division spindles in mouse oocytes and preimplantation embryos

MAP kinases of the ERK family play important roles in oocyte maturation, fertilization, and early embryo development. The role of the signaling pathway involving ERK5 MAP kinase during meiotic and mitotic M-phase of the cell cycle is not well known. Here, we studied the localization of the phosphorylated, and thus potentially activated, form of ERK5 in mouse maturing oocytes and mitotically dividing early embryos. We show that phosphorylation/dephosphorylation, i.e. likely activation/inactivation of ERK5, correlates with M-phase progression. Phosphorylated form of ERK5 accumulates in division spindle of both meiotic and mitotic cells, and precisely co-localizes with spindle microtubules at metaphase. This localization changes drastically in the anaphase, when phospho-ERK5 completely disappears from microtubules and transits to the cytoplasmic granular, vesicle-like structures. In telophase oocytes it becomes incorporated into the midbody. Dynamic changes in the localization of phospho-ERK5 suggests that it may play an important role both in meiotic and mitotic division. (Folia Histochemica et Cytobiologica 2011, Vol. 49, No. 3, 528–534

Brugada syndrome: From diagnosis to treatment

Brugada syndrome is electrocardiographically characterised by ST segment elevation in right precordial leads and the occurrence of episodes of polymorphic ventricular tachycardia. It is also associated with a high risk of sudden death, which may be the first manifestation of the disease. Various mutations of SCN5A gene encoding for the cardiac sodium channel are among the proven causes of BS. ICD remains the only treatment for BS of proven efficacy. However, many questions about etiology, underlying mechanisms, safety of asymptomatic patients and treatment options for BS remain unanswered. (Cardiol J 2007; 14: 429-435

Comprehensive Approach to Increase Cyber Security and Resilience

In this paper the initial results of the European project CAMINO in terms of the realistic roadmap to counter cyber crime and cyber terrorism are presented. The roadmap is built in accordance to so called CAMINO THOR approach, where cyber security is perceived comprehensively in 4 dimensions: Technical, Human, Organizational, and Regulatory

Submassive pulmonary embolism as a mask of acute coronary syndrome

The paper presents a case of a 77-year-old man, who was admitted to hospital suffering from chest pain. The ECG showed horizontal ST segment depression in the V4-V6 leads. Non-ST segment elevation acute coronary syndrome was diagnosed. However, transthoracic echocardiography revealed signs of pulmonary embolism. The present case indicates the need to consider pulmonary embolism in the differential diagnosis of acute coronary syndromes and underlines the role of echocardiography, which should be performed at the earliest possible stage

Submassive pulmonary embolism as a mask of acute coronary syndrome

The paper presents a case of a 77-year-old man, who was admitted to hospital suffering from chest pain. The ECG showed horizontal ST segment depression in the V4-V6 leads. Non-ST segment elevation acute coronary syndrome was diagnosed. However, transthoracic echocardiography revealed signs of pulmonary embolism. The present case indicates the need to consider pulmonary embolism in the differential diagnosis of acute coronary syndromes and underlines the role of echocardiography, which should be performed at the earliest possible stage. (Cardiol J 2007; 14: 402-406

Synthesis of Novel Halogenated Heterocycles Based on o-Phenylenediamine and Their Interactions with the Catalytic Subunit of Protein Kinase CK2

: Protein kinase CK2 is a highly pleiotropic protein kinase capable of phosphorylating hundreds of protein substrates. It is involved in numerous cellular functions, including cell viability, apoptosis, cell proliferation and survival, angiogenesis, or ER-stress response. As CK2 activity is found perturbed in many pathological states, including cancers, it becomes an attractive target for the pharma. A large number of low-mass ATP-competitive inhibitors have already been developed, the majority of them halogenated. We tested the binding of six series of halogenated heterocyclic ligands derived from the commercially available 4,5-dihalo-benzene-1,2-diamines. These ligand series were selected to enable the separation of the scaffold effect from the hydrophobic interactions attributed directly to the presence of halogen atoms. In silico molecular docking was initially applied to test the capability of each ligand for binding at the ATP-binding site of CK2. HPLC-derived ligand hydrophobicity data are compared with the binding affinity assessed by low-volume differential scanning fluorimetry (nanoDSF). We identified three promising ligand scaffolds, two of which have not yet been described as CK2 inhibitors but may lead to potent CK2 kinase inhibitors. The inhibitory activity against CK2α and toxicity against four reference cell lines have been determined for eight compounds identified as the most promising in nanoDSF assay