Intracameral lidocaine as supplement to classic topical anesthesia for relieving ocular pain in cataract surgery

● AIM: To evaluate safety, efficacy, and patient adherence of intracameral lidocaine as supplement of classic topical anesthetic drops in cataract surgery. ● METHODS: A prospective and controlled trial including a large cohort of 1650 individuals suffering with bilateral cataract not complicated, in program by phacoemulsification surgery, were randomly assigned to 2 different groups for the type of anesthesia received, 0.4% oxybuprocaine hydrochloride (INN) drops, and INN drops associated to intracameral 1% lidocaine hydrochloride monohydrate. At the end of surgery, tables were assigned to each patient indicating the degree of pain (0-3) felt during the operation. ● RESULTS: Thirty-two percent of patients in group 1 declared to have not felt any pain against the 77% of patients in group 2. Fifty-nine percent of patients in group 1 complained about only a slight discomfort against 20% of group 2 patients. Only a small percentage of patients in group 1 (5%) admitted severe pain, while no patient in group 2 admitted severe pain. Four patients of group 2 reported an episode of transient amaurosis, lasting several hours after surgery. ● CONCLUSION: Intracameral administration of lidocaine is a simple and secure method able to increase the analgesia during the cataract surgery, eliminating the discomfort and increasing also the cooperation of the patients during the steps of manipulation

New retinal imaging for the visualization and analysis of vitreoretinal interface (VRI) by short-wavelength scanning laser ophthalmoscope (swSLO)

Background: The purpose of the study was to evaluate vitreoretinal interface (VRI) alteration with a short-wavelength scanning laser ophthalmoscope (swSLO), the Nidek F-10, and compare the results with those obtained by means of spectral-domain optical coherence tomography (SD-OCT). Methods: Thirty-six eyes were studied (20 patients, mean age 68 ± 12.3 years). All patients underwent a complete ophthalmologic examination, which comprised SD-OCT and Nidek F-10 analysis with short-wavelength blue laser. Eyes were divided into four groups depending on the degree of VRI alteration observed with the swSLO and SD-OCT. Statistical analysis was performed using the Chi-square test. P values less than 0.05 were considered statistically significant. Results: OCT analysis: eight eyes (22%) grade 0 (no abnormalities), 15 eyes (42%) grade 1 (preretinal cellophane); seven (19%) grade 2 (preretinal wrinkling); six (17%) grade 3 (macular pucker or hole). Nidek F-10 analysis: seven (19%) grade 0, 16 (45%) grade 1; seven (19%) grade 2; six (17%) grade 3. Chi-square = 0.099, P = 0.992. There was no statistically significant difference between the two instruments. Conclusion: Nidek F-10 allows both a quantitative and a qualitative evaluation of VRI and is equal to SD-OCT in detecting alteration of the inner portion of the retina, providing an easy way to evaluate and map differences in the inner vitreoretinal surface. © 2011 Vingolo et al, publisher and licensee Dove Medical Press Ltd

Novel organotin-PTA complexes supported on mesoporous carbon materials as recyclable catalysts for solvent-free cyanosilylation of aldehydes

The work was also funded by national funds through FCT, under the Scientific Employment Stimulus-Institutional Call (CEEC-INST/00102/2018). AGM is grateful to Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento ( IST-ID ) for his post-doctoral fellowship through grant no. BL133/2021-IST-ID . AP and AMF are grateful to FCT and Instituto Superior Técnico (IST), Portugal through DL/57/2017 (Contract no. IST-ID/197/2019 and IST-ID/131/2018). This publication is also supported by the RUDN University Strategic Academic Leadership Program (recipient AJLP, preparation). The authors also acknowledge the Portuguese NMR Network (IST-UL Centre) for access to the NMR facility. Publisher Copyright: © 2023 Elsevier B.V.New organotin compounds with general formula [(PTA-CH2-C6H4-p-COO)SnR3]Br (where R is Me for 3 and Ph for 4; PTA = 1,3,5-triaza-7-phosphaadamantane), bearing the methylene benzoate PTA derivative, were synthesized through a mild two-step process. The compounds were characterized by Fourier transform infrared spectroscopy, electrospray ionization mass spectrometry, elemental analysis and nuclear magnetic resonance spectroscopy (NMR). They were heterogenized on commercially available activated carbon (AC) and multi-walled carbon nanotubes (CNT), as well as on their chemically modified analogues. The obtained materials were characterized by scanning electron microscopy, transmission electron microscopy and X-ray photoelectron spectroscopy. Complex 3 supported on activated carbon (3-AC) was found to be an active and recyclable catalyst for the cyanosilylation of several aromatic and aliphatic aldehydes. Using 3-AC with a low loading of 0.1 mol% several substrates were quantitatively converted, within just 5 min at 50 °C and under microwave irradiation in solvent-free conditions. Multinuclear NMR analysis suggested a mechanism that potentially involves a double activation process, where the nucleophilic phosphorus at the PTA derivative acts as a Lewis base and the Sn(IV) metal centre as a Lewis acid.publishersversionpublishe

VALUTAZIONE CLINICA SULL'IMPIEGO DELLA BENDALINA NELLA TERAPIA DELLA CATARATTA (Clinical evaluation on the use of Bendaline in cataract therapy)

The Authors administered Bendaline, the lysine salt of phenylmethyl - indazolyloxyacetic acid, by the oral route in 45 patients with pre-senile and senile cataract, at the dose of a tablet (500 mg) three times daily for 12 months. 75 eyes assessed for correct visual acuity showed: 16 (21%) improvement, 55 (73%) no change and 4 (5,3%) worsening. The Authors conclude for a positive therapeutic effect of the drug in cataract

Sturge-Weber syndrome associated with monolateral ocular melanocytosis, iris mammillations, and diffuse choroidal haemangioma

We present the case of a 12-year-old boy with Sturge-Weber syndrome and ocular melanocytosis who presented with bilateral naevus flammeus of the face and hyperpigmentation of the right iris associated with ipsilateral iris mammillations. The patient had glaucoma and a diffuse choroidal haemangioma of the right eye. Optical coherence tomography of the anterior segment confirmed iris hyper-pigmentation and did not show abnormalities of the chamber angle structures. B-scan ultrasonography and enhanced depth imaging optical coherence tomography were performed and showed a marked difference in thickness and reflectance between the right and left choroid. Visual field examinations with perimetry showed early defects in the right eye. Peripapillary optical coherence imaging showed borderline values of retinal nerve fibre layer thickness reduction in the right eye. Sturge-Weber syndrome associated with ocular melanocytosis and iris mammillations is an extremely rare condition. This paper highlights the role of multi-imaging methods in the enhanced evaluation of rare diseases towards choosing the most appropriate management strategies and improving the follow-up of patients over time

Tanganan Goes to Town

It can be said as a matter of fact that almost all people, generally follow the norms and standards of the society they belong to. Individuals have the naturally tendency to live their lives according to what their culture dictates. There can be as many varieties of cultures as there are societies in the world and this obviously means that there can be as many subcultures to conform to. The crime subculture is one such realm. The occurrence of crime is largely held to be inherent in Philippine society. Especially in urban areas, it is generally believed to not only be a constant threat to one\u27s safety but also an inescapable part of city life. As in any other society, criminal activity is considered to be deviant behavior. But in some parts of the world, such as in a barangay in Iloilo (as has been periodically reported newspapers), the residents are being socialized into criminal activity, shifting the general perception of crime from being something that is deviant to something of a standard. The group\u27s story revolves around a young man\u27s choice of a career path which has been invariably influenced by his socialization in a subculture that does not acknowledge the deviancy of crime. Ramon Tanganan was born and raised in the rural barangay of Abucay, Sta. Filomena, home of the notorious Manila bank robbers, the Asoaso Gang. Like every kid in his community, all he wants to become is an Asoaso: hero and breadwinner for the village, just like his slain father. Because of his clumsiness, the gang leader Magno decides that he is unfit to become a bank robber and wouldn\u27t train him to become one like the others. It is now up to Ramon to make himself the robber that he wants to be, and to go to Manila in pursuit of his dream