Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216

Impact of single nucleotide polymorphisms on the efficacy and toxicity of egfr tyrosine kinase inhibitors in advanced non-small cell lung cancer patients.

EGFR tyrosine kinase inhibitors (EGFR-TKIs) are the treatment of choice for advanced-stage (IIIB-IV) NSCLC patients with mutations in EGFR. However, EGFR-TKIs clinical outcomes vary from person to person and these inter-individual differences may be due to genetic factors such as single nucleotide polymorphisms (SNPs). SNPs in genes involved in EGFR-TKIs pharmacodynamics, metabolism and mechanism of action have been demonstrated to be associated with response, survival and toxicity in advanced NSCLC patients treated with EGFR-TKIs. Here we review the influence of gene polymorphisms in the EGFR pathway on clinical outcome and toxicity to EGFR-TKIs in advanced NSCLC patients. The EGFR-216 polymorphism has reported a strong association between response and/or survival to EGFR-TKIs in Caucasian population. Similarly, the effect of EGFR-CA repeats polymorphisms on survival of advanced NSCLC patients treated with EGFR-TKIs have been confirmed both in Caucasian and Asian population. The influence on toxicity of the -216, -191, CA repeats, Arg497Lys and Asp994Asp polymorphisms in EGFR have also been confirmed. Polymorphisms in AKT (rs1130214 and rs1130233) and SMAD3 (rs6494633, rs11071938 and rs11632964) have been associated with survival in advanced NSCLC patients treated with EGFR-TKIs. However, data come from a limited number of studies and need to be confirmed. Finally, polymorphisms in genes coding proteins of the membrane transporters and cytochrome P450 enzymes have been less extensively investigated. There are few studies with small samples, which complicated the generalization of their role in EGFR-TKIs treatment

Estudo de descargas elétricas atmosfericas em sistemas convectivos organizados: análise preliminar

Cloud-to-ground flashes by convection system were located over São Paulo State on September 30, 1991. Radar data showed reflectivities exceeding 60 dBZ associated to regions with rates of precipitation above 100 mmh-1 and clouds with top about 15 km. The propagation of this system was simultaneously monitored by meteorological radar and by a system of lightning detection LPATS (Lightning Position and Tracking System). Some regions presented high peak current of strikes

Interleukins as new prognostic genetic biomarkers in non-small cell lung cancer

Surgery is the standard treatment for early-stage NSCLC, and platinum-based chemotherapy remains as the treatment of choice for advanced-stage NSCLC patients with naïve EGFR status. However, overall 5-years relative survival rates are low. Interleukins (ILs) are crucial for processes associated with tumor development. In NSCLC, IL1B, IL6, IL12A, IL13 and IL16 gene polymorphisms may contribute to individual variation in terms of patient survival. The purpose of this study was to evaluate the association between IL gene polymorphisms and survival in NSCLC patients. A prospective cohorts study was performed, including 170 NSCLC patients (114 Stage IIIB-IV, 56 Stage I-IIIA). IL1B (C > T; rs1143634), IL1B (C > T; rs12621220), IL1B (C > G; rs1143623), IL1B (A > G; rs16944), IL1B (C > T; rs1143627), IL6 (C > G; rs1800795), IL12A (C > T; rs662959), IL13 (A > C; rs1881457) and IL16 (G > T; rs7170924) gene polymorphisms were analyzed by PCR Real-Time. Patients with IL16 rs7170924-GG genotype were in higher risk of death (p = 0.0139; HR = 1.82; CI95% = 1.13-2.94) Furthermore, carriers of the TT genotype for IL12A rs662959 presented higher risk of progression in the non-resected NSCLC patient subgroup (p = 0.0412; HR = 4.49; CI95% = 1.06-18.99). The rest of polymorphisms showed no effect of on outcomes. Our results suggest that IL16 rs7170924-GG and IL12A rs662959-TT genotypes predict higher risk of death and progression, respectively, in NSCLC patients. No influence of IL1B rs12621220, IL1B rs1143623, IL1B rs16944, IL1B rs1143627, IL6 rs1800795, IL13 rs1881457 on NSCLC clinical outcomes was found in our patients

Analysis of mebendazole binding to its target biomolecule by laser flash photolysis

[EN] Mebendazole (MBZ) and related anticancer benzimidazoles act binding the beta-subunit of Tubulin (TU) before dimerization with alpha-TU with subsequent blocking microtubule formation. Laser flash photolysis (LFP) is a new tool to investigate drug-albumin interactions and to determine binding parameters such as affinity constant or population of binding sites. The aim of this study was to evaluate the interactions between the nonfluorescent mebendazole (MBZ) and its target biomolecule TU using this technique. Before analyzing the MBZ@TU complex it was needed to determine the photophysical properties of MBZ triplet excited state ((3)MBZ*) in different media. Hence, 3MBZ* showed a transient absorption spectrum with maxima at 520 and 375 nm and a lifetime much longer in acetonitrile (12.5 mu s) than in water (260 ns). The binding of MBZ to TU produces a greater increase of the lifetime of 3MBZ* (25 mu s). This fact and the strong electron acceptor capability observed for (3)MBZ* evidence that MBZ must not be located close to any electron donor amino acid of TU such as its tryptophan or cysteine residues. Adding increasing amounts of MBZ to aqueous TU was determined the MBZ-TU binding constant (2.0 +/- 0.5 x 10(5) M-1 at 298 K) which decreased with increasing temperature. The LFP technique has proven to be a powerful tool to analyze the binding of drug-TU systems when the drug has a detectable triplet excited state. Results indicate that LFP could be the technique of choice to study the interactions of non-fluorescent drugs with their target biomolecules. (C) 2015 Elsevier B.V. All rights reserved.Financial support from the Spanish Government (grants CTQ2010-19909, BFU2011-23416 and SEV 2012-0267), the Generalitat Valenciana (Prometeo II/2013/005) and Comunidad de Madrid (S2010/BMD-2353) is gratefully acknowledged.Jornet Olivé, MD.; Bosca Mayans, F.; Andreu, JM.; Domingo, L.; Tormos Faus, RE.; Miranda Alonso, MÁ. (2016). Analysis of mebendazole binding to its target biomolecule by laser flash photolysis. Journal of Photochemistry and Photobiology B Biology. 155:1-6. https://doi.org/10.1016/j.jphotobiol.2015.12.003S1615

Amazonian Climate

Pages: 79-9

Dry to wet season LBA campaign in the Amazon radiation, clouds and climate interactions

During the Iransilion fromthe dry to wet season in 2002 (Seplember and October). an atmospheric intensive field campaign was carried in the southwestern region of the Amazon Basin within the framework of. The Large Scale Biosphere Atmosphere Experiment in Amazonia -LBA. The specific objectives of the DRYTOWET/LBA campaign were 10 describe and analyze: the global and large scale conb"ols of the beginning of the rainy season in the Amazon Region; the impact of convection in the Amazon region on the global and regional clímate in the transition season; the transition season in terms of cloud patlem evolution and aerosol concentration; the weather systems and air mass evolution during the transitíon from the dry to wet season; the several convective features of the Ar1:1azon region in lhe transition season including fite cycle. rainfall intensíly, líghtning. dynamics and thermodynamics; the relationship between CCN and convective patterns; the temperature inversíon equilibrium ín the presence of a mixed I.ayer wilh aerosol and its evolution afterthe first major rains; the evolution of the PBL during the transition season as a function of soil moísture and of evapotranspiration; the surface and PBL radíatíve budgel before, during and after the beginning of the rainy season. over forest and over pasture; the impact of land cover heterogeneity on PBL and surface layer turbulence during the transition season; the evolution of surface energy. momentum. water and CO2 budgets in pasture and forest and íts seasonal and interannual variabílity; the radíative transfer processes in the presence of aerosol and to what extent they modify the processes associated to water vapor seasonality; the microphysics processes with different aerosol concentration and to improve the ability to model the different processes in an integrated view of clímate and regional weather

The low level jet and the south American monsoon variability in the SALLJEX period

In january 2003 there was ocurrence of synoptic and mesoscale systems over south america : SACZ, Atlantic upper level cyclonic vortice, frontal systems, MCCs and short wave disturbance. During. the month there was variability of the low level meridional wind in the region of the LLJET and in the atmospheric features related to the south america monsoon. The discussions is based on CPTEC reanalysis for the SALLJEX period using CPTEC/COLA AGCM T126 L28 and the psas assimilation system incluiding data from the experiment. The atmospheric fields are shown for one epsode of MCC and another of SACZ

Amazonian climate: results and future research

Some of the results from the climate component of the Large Scale Biosphere-Atmosphere Experiment in Amazonia (LBA), which are presented in this Special Issue are summarised. Recent advances in Amazonian climate modelling are also discussed. There is a range of papers which fall into three groups: surface fluxes and boundary layer growth; convection, clouds and rainfall; and climate modelling. The new insight given by this work is discussed and an argument is made for future research to employ a wider approach to Amazonian climate modelling.Pages: 187-19