Diethyl 2-{(dibenzyl­amino)[4-(trifluoro­meth­yl)phen­yl]meth­yl}malonate

The asymmetric unit of the title compound, C29H30F3NO4, contains two independent mol­ecules. In each independent mol­ecule, one of two terminal ethyl groups is disordered over two conformations: the occupancies of major components were fixed at 0.53 and 0.64 in the two mol­ecules. In the crystal structure, weak inter­molecular C—H⋯O hydrogen bonds link mol­ecules into chains propagating along [10]

4-tert-Butyl-4′-(4-meth­oxy­phen­yl)-3′-(4-methyl­phen­yl)-1,2,3,4-tetra­hydro­spiro­[naphthalene-2,5′(4′H)-1,2-oxazol]-1-one

In the title compound, C30H31NO3, the tolyl ring is almost coplanar with the isoxazole ring [dihedral angle = 12.51 (7)°], whereas the meth­oxy­phenyl ring is almost perpendicular to the isoxazole ring [dihedral angle = 89.77 (5)°]. In the crystal, mol­ecules are connected through C—H⋯O hydrogen bonds, forming chains running along the a axis

Synthesis, characterization and coordination chemistry of substituted β-amino dicarbonyls

AbstractAn efficient and facile method for the synthesis of novel structurally diverse β-amino dicarbonyl compounds is described by exploring the aza-Michael addition reaction in an aqueous medium as a key step. Thereby, 2-(aryl-disubstituted-amino-1-yl-methyl)-malonic acid diethyl esters were achieved in a good to excellent yields. These products were easily isolated with enough purity just by using simple recrystallization. The crystals of the compounds (17) and (24) have been obtained and studied by X-ray crystallographic analyses

(2E)-4-tert-Butyl-2-(4-meth­oxy­benzyl­idene)-3,4-dihydro­naphthalen-1(2H)-one

In the title compound C22H24O2, the exocyclic C=C double bond is in an E configuration and the tert-butyl group is in an axial position on the cyclo­hexa­none ring. The cyclo­hexa­none ring in the dihydro­naphthalene fused-ring system adopts a half-chair conformation in both independent two mol­ecules in the asymetric unit. The benzene ring system is oriented angles of 43.97 (12) and 39.24 (12)° with respect to the naphthyl ring system in the two independent mol­ecules. In the crystal, mol­ecules are linked via C—H⋯O hydrogen bonds and C—H⋯π inter­actions

Diethyl 2-[(3,5-dimethyl-1H-pyrazol-1-yl)(4-meth­oxy­phen­yl)meth­yl]propane­dioate

The title compound, C20H26N2O5, was prepared in good yield (76%) through condensation of diethyl (4-meth­oxy­benz­yl)propane­dioate with 3,5-dimethyl-1H-pyrazole. The dihedral between the benzene and pyrazole rings is 83.96 (10)°. The crystal packing is stabilized by a C—H⋯O inter­action, which links the mol­ecules into centrosymmetric dimers

3,4-Bis(4-nitro­phen­yl)-1,2,5-oxadiazole 2-oxide

The title compound, C14H8N4O6, a new 1,2,5-oxadiazole N-oxide derivative, was formed by dimerization of 4-nitro­benz­al­de­hyde oxime. The compound crystallizes with two independent mol­ecules per asymmetric unit. The N-oxide O atom is disordered over two sites in each mol­ecule; site occupancy factors are 0.57/0.43 and 0.5/0.5. The mean planes through the two benzene rings are inclined to the planar 1,2,3-oxadiazole ring by 25.03 (11) and 41.64 (11)° in one mol­ecule, and 22.58 (11) and 42.66 (11)° in the other mol­ecule, the smaller angle being for the ring on the oxide side of the oxadiazole ring in each case. In the crystal structure, the individual mol­ecules form centrosymmetric dimers linked via C—H⋯O hydrogen bonds. The dimers of one mol­ecule are then linked to those of the other mol­ecule via C—H⋯O hydrogen bonds, forming a three-dimensional network

Poly[[bis­{μ3-2-[(3,5-dimethyl-1H-pyrazol-1-yl)(phen­yl)meth­yl]propane­dioato}tetra­sodium(I)] 7.5-hydrate]

The asymmetric unit of the title polymer, {[Na4(C15H14N2O4)2]·7.5H2O}n, contains two 2-[(3,5-dimethyl-1H-pyrazol-1-yl)(phen­yl)meth­yl]propane­dioate (ppmp) anions, eight water mol­ecules (one located on a twofold rotation axis) and five sodium cations (one located on an inversion center and the other one located on a twofold rotation axis). The carboxyl­ate groups of the ppmp anions and the water mol­ecules bridge the Na cations, forming a two-dimensional polymeric structure. In the structure there are two types of coordination environment around the metal cations: one Na cation is coordinated by five O atoms in a distorted square-pyramidal geometry while the other four Na cations are coordinated by six O atoms in a distorted octa­hedral geometry. Extensive O—H⋯O and O—H⋯N hydrogen bonding is present in the crystal structure. The H atoms of one methyl group of the ppmp anion are disordered equally over two positions

Idiopathic encapsulating peritonitis revealed by an acute bowel occlusion in a young patient

La péritonite encapsulante est une péritonite chronique aboutissant à une membrane fibreuse épaisse, blanc nacré. C’est une affection rare dont la physiopathologie reste mal expliquée et le diagnostic est souvent porté en peropératoire ; elle peut être la cause d’une urgence chirurgicale, le caractère idiopathique est exceptionnel, retrouvé chez l’adolescent provenant des régions tropicales et subtropicales, jamais dans le Maghreb. Nous rapportons l’observation d’une jeune patiente marocaine de 18 ans, opérée pour une occlusion intestinale, chez qui le diagnostic d’une péritonite encapsulante a été posé en peropératoire.Encapsulating peritonitis is a chronic peritonitis leading to the constitution of a thick pearly-white fibrosis membrane. It is a rare affection, which physiopathology is poorly elucidated. Diagnosis is usually assessed during surgery; the idiopathic character is exceptional, occurring in teenagers coming from the tropical and subtropical countries, never in Maghreb. We report an unpublished case of an 18-year-old patient, admitted for bowel obstruction; diagnosis was made during surgery revealing an encapsulating peritonitis

Polymorphism of the Fractalkine Receptor CX3CR1 and Systemic Sclerosis-associated Pulmonary Arterial Hypertension

Fractalkine (FKN) and its receptor CX3CR1 are critical mediators in the vascular and tissue damage of several chronic diseases, including systemic sclerosis (SSc) and pulmonary arterial hypertension (PAH). Interestingly, the V249I and T280M genetic polymorphisms influence CX3CR1 expression and function. We investigated whether these polymorphisms are associated with PAH secondary to SSc. CX3CR1 genotypes were analyzed by PCR and sequencing in 76 patients with limited SSc and 204 healthy controls. PAH was defined by colorDoppler echocardiography. Homozygosity for 249II as well as the combined presence of 249II and 280MM were significantly more frequent in patients with SSc compared to controls (17 vs 6%, p = 0.0034 and 5 vs 1%, p = 0.0027, respectively). The 249I and 280M alleles were associated with PAH (odd ratio [OR] 2.2, 95% confidence interval [CI] 1.01-4.75, p = 0.028 and OR 7.37, 95%CI: 2.45-24.60, p = 0.0001, respectively). In conclusion, the increased frequencies of 249I and 280M CX3CR1 alleles in a subgroup of patients with SSc-associated PAH suggest a role for the fractalkine system in the pathogenesis of this condition. Further, the 249I allele might be associated with susceptibility to SSc