Retrofit 2050: critical challenges for urban transitions

Scaling up retrofit presents a number of critical challenges for the transition to urban sustainability. Drawing together insights from the EPSRC Retrofit 2050 project this briefing sets out key success factors that need to be in place to deliver sustainable futures for UK cities

Towards Sustainable Informal Settlements: A Toolkit for Community-Led Upgrading in Durban, South Africa

Across sub-Saharan Africa, 238 million people live in slums or informal settlements. Because of rapid urbanisation and population growth, informal settlements have become a major challenge in the urban landscape, exacerbating issues related to poverty, inadequate infrastructure, housing and poor living conditions. As part of a collaborative interdisciplinary project ISULABANTU, this paper provides an overview of toolkits focused on informal settlement upgrading (ISU) in South Africa and presents the process of an integrated toolkit development for sustainable human settlements in Durban, which was informed by participatory action research and co-production strategies. A toolkit can be a valuable and effective way of engaging communities in the process of ISU and for community members to take full ownership of the process, designing strategies that best respond to their needs. The review of existing toolkits has revealed several critical gaps related to community-led practices, integrated approaches to housing and environmental management, and gender. The integrated ISULABANTU toolkit aims to fill these gaps and complement the existing resources. It provides a framework for action research, active involvement of and partnership building with local communities in upgrading practices required to achieve sustainable human settlements

A dataset of community perspectives on living conditions and disaster risk management in informal settlements: A case study in KwaZulu-Natal Province, South Africa

This article describes a dataset of community perspectives on living conditions and disaster risk management in Khan Road, a non-serviced informal settlement, located in Pietermaritzburg, the capital of KwaZulu-Natal province in South Africa. The data were collected by local community researchers via a structured questionnaire of 159 informal dwellers conducted between August and September 2022, using mobile phones via KoboToolbox. The dataset was analysed using exploratory data analysis (EDA) techniques. This household survey is part of a research project aiming to develop an evidence base of opportunities, risks and vulnerabilities related to housing construction and resource management in incremental upgrading of informal settlements in South Africa. This dataset can be used by local practitioners and policymakers involved in decision-making for informal settlement upgrading and help them prioritise resources and upgrading interventions based on what informal dwellers need. Furthermore, this cleaned dataset could support the analysis of further South African data guiding the development of digital platforms as a real-time resource management tool or guide the enhancement of existing theoretical frameworks in the field of participatory design and co-production used by academic scholars

Effects of air embolism size and location on porcine hepatic microcirculation in machine perfusion

The handling of donor organs frequently introduces air into the microvasculature, but little is known about the extent of the damage caused as a function of the embolism size and distribution. Here we introduced embolisms of different sizes into the portal vein, the hepatic artery, or both during the flushing stage of porcine liver procurement. The outcomes were evaluated during 3 hours of machine perfusion and were compared to the outcomes of livers with no embolisms. Dynamic contrast-enhanced ultrasound (DCEUS) was used to assess the perfusion quality, and it demonstrated that embolisms tended to flow mostly into the left lobe, occasionally into the right lobe, and rarely into the caudate lobe. Major embolisms could disrupt the flow entirely, whereas minor embolisms resulted in reduced or heterogeneous flow. Embolisms occasionally migrated to different regions of the same lobe and, regardless of their size, caused a general deterioration in the flow over time. Histological damage resulted primarily when both vessels of the liver were compromised, whereas bile production was diminished in livers that had arterial embolisms. Air embolisms produced a dose-dependent increase in vascular resistance and a decline in oxygen consumption. This is the first article to quantify the impact of air embolisms on microcirculation in an experimental model, and it demonstrates that air embolisms have the capacity to degrade the integrity of donor organs. The extent of organ damage is strongly dependent on the size and distribution of air embolisms. The diagnosis of embolism severity can be safely and easily made with DCEUS

Retrofit 2050: Critical challenges for urban transitions

Scaling up retrofit presents a number of critical challenges for the transition to urban sustainability. Drawing together insights from the EPSRC Retrofit 2050 project this briefing sets out key success factors that need to be in place to deliver sustainable futures for UK cities

Sequential evaluation of serum hepcidin in anemic myeloma patients: Study of correlations with myeloma treatment, disease variables, and anemia response

Hepcidin is a liver-derived hormone with a central role In Iron regulation and In anemia of Inflammation. Its correlations with disease variables, anemia response (AR), and responses to treatment have not been investigated In multiple myeloma (MM). A cohort of anemic MM patients undergoing treatment with Immunomodulatory drug (IMiDs)-based regimens (n = 18) or conventional chemotherapy (n = 16) was studied. Overall, hepcidin decreased significantly between baseline and treatment Cycles 2 and 4 (P < 0.05), and this was more profound In the IMiDs group compared with the conventional group. Baseline hepcidin Inversely correlated with baseline hemoglobin (Hb) and platelets (PLT) and positively correlated with beta 2M, ferritin, transferrin saturation (TSAT%), and International Scoring System (ISS) (P < 0.05). Abnormally high baseline hepcidin inversely correlated with duration of response (DOR) In all studied patients and In the conventional group. Abnormally high hepcidin before treatment Cycles 2 and 3 predicted for AR and disease response (DR), respectively, In all studied patients (P < 0.05). These results suggest that serum hepcidin correlates with significant MM variables and may serve as a surrogate marker for MM and as a predictor for response Indicators

Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

International audienc