PROSPECÇAO DE PATENTES DE PERSONALIDADE NOS JOGOS

A personalidade é uma característica que revela muitas informações sobre um indivíduo. Estas informações podem ser utilizadas no âmbito computacional para tomada de decisão via sistemas de recomendação, interação personalizada, dentre outros. Para que isto seja possível, estudos tentam desenvolver maneiras de extrair a personalidade de forma estruturada para que possam ser utilizadas em sistemas computacionais. O objetivo desta prospecção é o de verificar o estado atual da técnica e identificar possíveis oportunidades de desenvolvimento na área

PROSPECÇÃO TECNOLÓGICA DO TERMO AGENTE INTELIGENTE PARA REDES COM FOCO NA CIÊNCIA DA COMPUTAÇÃO

Em uma rede de computadores de tamanho considerável, é comum a dificuldade de gerenciar recursos de hardware para detectar problemas ou planejar escalonamento de recursos. A aplicação de agente inteligente pode vir a melhorar o processo de gerenciamento para redes. Este artigo tem como objetivo fazer um mapeamento das tecnologias já desenvolvidas, bem como analisando as potencialidades e a evolução dos produtos na área no que se refere à aplicação de agentes inteligentes no gerenciamento de redes. A prospecção foi realizada no Banco Europeu de Patentes, no Banco da Organização Mundial de Propriedade Intelectual, no Banco Americano de Marcas e Patentes e no Banco de dados do Instituto Nacional de Propriedade Industrial do Brasil

A Systematic Mapping Study on Search Engine Industry’s Patent Innovations Focused on Matching the Search Results to User Intent

This report presents a systematic mapping study to survey patent documents in Brazilian and international databases to characterize the technical state-of-the-art in search engines under the intent matching paradigm as well as to discover the size of academia initiatives as part of the technical state-of-the-art agenda to commercial innovation ventures in the search engine industry. The goal is achieved by the identification of the search engine industry most common innovation claims concerning the intent matching paradigm and by the discussion of important issues regarding its patent application patterns, such as the search engine industry’s proficiency to churn its innovative landscape.This report presents a systematic mapping study to survey patent documents in Brazilian and international databases to characterize the technical state-of-the-art in search engines under the intent matching paradigm as well as to discover the size of academia initiatives as part of the technical state-of-the-art agenda to commercial in- novation ventures in the search engine industry. The goal is achieved by the identifica- tion of the search engine industry most common innovation claims concerning the in- tent matching paradigm and by the discussion of important issues regarding its patent application patterns, such as the search engine industry’s proficiency to churn its inno- vative landscape

Animated Pedagogical Agent in a Learning Environment

Abstract: Artificial Intelligence is an important area in the field of Computing applied to Education in terms of technological implementation. This paper describes IVTE, Intelligent Virtual Teaching Environment, implemented by Multi-Agents technology including pedagogical features, represented by Guilly. Guilly is a Animated Pedagogical Agent that acts based on a student model and teaching strategies

A non-functional galanin receptor-2 in a multiple sclerosis patient

Multiple Sclerosis (MS) is an inflammatory neurodegenerative disease that affects approximately 2.5 million people globally. Even though the etiology of MS remains unknown, it is accepted that it involves a combination of genetic alterations and environmental factors. Here, after performing whole exome sequencing, we found a MS patient harboring a rare and homozygous single nucleotide variant (SNV; rs61745847) of the G-protein coupled receptor (GPCR) galanin-receptor 2 (GALR2) that alters an important amino acid in the TM6 molecular toggle switch region (W249L). Nuclear magnetic resonance imaging showed that the hypothalamus (an area rich in GALR2) of this patient exhibited an important volumetric reduction leading to an enlarged third ventricle. Ex vivo experiments with patient-derived blood cells (AKT phosphorylation), as well as studies in recombinant cell lines expressing the human GALR2 (calcium mobilization and NFAT mediated gene transcription), showed that galanin (GAL) was unable to stimulate cell signaling in cells expressing the variant GALR2 allele. Live cell confocal microscopy showed that the GALR2 mutant receptor was primarily localized to intracellular endosomes. We conclude that the W249L SNV is likely to abrogate GAL-mediated signaling through GALR2 due to the spontaneous internalization of this receptor in this patient. Although this homozygous SNV was rare in our MS cohort (1:262 cases), our findings raise the potential importance of impaired neuroregenerative pathways in the pathogenesis of MS, warrant future studies into the relevance of the GAL/GALR2 axis in MS and further suggest the activation of GALR2 as a potential therapeutic route for this disease1917282CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP480138/2013-323038.007775/2014-98; 7350-15-5; 1197-79-42013/24293-7, 2015/07925-5, 2016/06488-3Associacao Beneficente Alzira Denise Hertzog Silva (ABADHS); Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil)CAPES [23038.007775/2014-98, 7350-15-5, 1197-79-4]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)National Council for Scientific and Technological Development (CNPq) [480138/2013-3]; Fundacao de Amparo a Pesquisa do Estado de Sao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/24293-7, 2015/07925-5, 2016/06488-3

Role of body mass index and gestational weight gain on preterm birth and adverse perinatal outcomes

The association of body mass index (BMI) and gestational weight gain (GWG) with preterm birth (PTB) remains controversial in the literature. To evaluate different maternal BMI and GWG categories, according to the initial BMI, in relation to different PTB subtypes and perinatal outcomes, we conducted a secondary analysis of a multicentre cross-sectional study, along with a nested case-control study including PTB from 20 centers in Brazil. Pre-pregnancy underweight was associated with a lower risk of provider-initiated PTB, while overweight and obesity were associated with a higher risk of provider-initiated PTB and a lower risk of spontaneous preterm birth. Insufficient gestational weight gain was associated with a higher prevalence of spontaneous PTB and preterm premature rupture of membranes. Excessive GWG correlated with a higher prevalence of provider-initiated PTB or preterm premature rupture of membranes. Irrespective of the initial BMI, the greater the rate of GWG, the higher the predicted probability of all PTB subtypes, except for spontaneous PTB in underweight women and those with normal BMI. On multivariate analysis, the initial BMI was shown to be the only factor associated with pi-PTB. Briefly, further studies evaluating the risk for PTB should consider that GWG may have a different role depending on the initial BMI and PTB subtype9CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP401636/2013-5sem informaçãoFAPESP (Foundation for Research Support of the State of Sao Paulo) BrazilFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); CNPq (Brazilian National Research Council) BrazilNational Council for Scientific and Technological Development (CNPq); Bill and Melinda Gates FoundationGates Foundation [401636/2013-5, 05/2013]; Brazilian National Research Council (CNPq)National Council for Scientific and Technological Development (CNPq) [401636/2013-5, 05/2013

Cluster analysis identifying clinical phenotypes of preterm birth and related maternal and neonatal outcomes from the Brazilian Multicentre Study on Preterm Birth

To explore a conceptual framework of clinical conditions associated with preterm birth (PTB) by cluster analysis, assessing determinants for different PTB subtypes and related maternal and neonatal outcomes. Methods Secondary analysis of the Brazilian Multicentre Study on Preterm Birth of 33 740 births in 20 maternity hospitals between April 2011 and July 2012. In accordance with a prototype concept based on maternal, fetal, and placental conditions, an adapted k-means model and fuzzy algorithm were used to identify clusters using predefined conditions. The mains outcomes were phenotype clusters and maternal and neonatal outcomes. Results Among 4150 PTBs, three clusters of PTB phenotypes were identified: women who had PTB without any predefined conditions; women with mixed conditions; and women who had pre-eclampsia, eclampsia, HELLP syndrome and fetal growth restriction. The prevalence of different preterm subtypes differed significantly in the three clusters, varying from 80.95% of provider-initiated PTBs in cluster 3-6.62% in cluster 1 (P<0.001). Although some maternal characteristics differed among the clusters, maternal and neonatal outcomes did not. Conclusions The analysis identified three clusters with distinct phenotypes. Women from the different clusters had different subtypes of PTB and maternal and pregnancy characteristics.1461110117CNPQ - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPESP – Fundação de Amparo à Pesquisa Do Estado De São PauloSem informaçãoSem informaçã