Oncolytic virotherapy for anaplastic and poorly differentiated thyroid cancer: a promise or a clinical reality?

Oncolytic viruses (OVs) selectively infect and lyse cancer cells. A direct lytic effect of OVs has been theorized in the initial studies; however, the antineoplastic effect of OVs is also due to the induction of an immune response against cancer cells. Anaplastic thyroid cancer is one of the most aggressive human malignancies with a short survival time of about 6–12 months from the diagnosis. The lack of effective therapies has prompted to investigate the efficacy of OVs in anaplastic thyroid carcinoma. Different OVs have been tested in preclinical studies, either as single agents or in combinatorial treatments. In this review, the results of these studies are summarized and future perspective discussed

Lessons Learned from EVALITA 2020 and Thirteen Years of Evaluation of Italian Language Technology

This paper provides a summary of the 7th Evaluation Campaign of Natural Language Processing and Speech Tools for Italian (EVALITA2020) which was held online on December 17th, due to the 2020 COVID-19 pandemic. The 2020 edition of Evalita included 14 different tasks belonging to five research areas, namely: (i) Affect, Hate, and Stance, (ii) Creativity and Style, (iii) New Challenges in Long-standing Tasks, (iv) Semantics and Multimodality, (v) Time and Diachrony. This paper provides a description of the tasks and the key findings from the analysis of participant outcomes. Moreover, it provides a detailed analysis of the participants and task organizers which demonstrates the growing interest with respect to this campaign. Finally, a detailed analysis of the evaluation of tasks across the past seven editions is provided; this allows to assess how the research carried out by the Italian community dealing with Computational Linguistics has evolved in terms of popular tasks and paradigms during the last 13 years

Microalgae as a Nutraceutical Tool to Antagonize the Impairment of Redox Status Induced by SNPs: Implications on Insulin Resistance

Microalgae represent a growing innovative source of nutraceuticals such as carotenoids and phenolic compound which are naturally present within these single-celled organisms or can be induced in response to specific growth conditions. The presence of the unfavourable allelic variant in genes involved in the control of oxidative stress, due to one or more SNPs in gene encoding protein involved in the regulation of redox balance, can lead to pathological conditions such as insulin resistance, which, in turn, is directly involved in the pathogenesis of type 2 diabetes mellitus. In this review we provide an overview of the main SNPs in antioxidant genes involved in the promotion of insulin resistance with a focus on the potential role of microalgae-derived antioxidant molecules as novel nutritional tools to mitigate oxidative stress and improve insulin sensitivity

Gender influence on professional satisfaction and gender issue perception among young oncologists. A survey of the Young Oncologists Working Group of the Italian Association of Medical Oncology (AIOM)

Background: The professional gender gap is increasingly recognised in oncology. We explored gender issues perception and gender influence on professional satisfaction/gratification among young Italian oncologists. Methods: Italian oncologists aged 6440 years and members of the Italian Association of Medical Oncology were invited to participate in an online survey addressing workload/burnout, satisfaction in professional abilities and relations, relevant factors for professional gratification, and gender barriers. \u3c72 test for general association or \u3c72 test for trend was used to analyse the data. Results: 201 young oncologists participated in the survey: 67% female, 71% aged 30-40 years, 41% still in training and 82% without children. Women and men were equally poorly satisfied by the relations with people occupying superior hierarchical positions. There was heterogeneity between women and men in current (p=0.011) and expected future (p=0.007) satisfaction in professional abilities: women were more satisfied by current empathy and relations with colleagues and were more confident in their future managerial and team leader skills. The most important elements for professional gratification indicated by all participants were, in general, work-life balance (36%) and intellectual stimulation/research (32%); specifically for women, work-life balance (48%) and intellectual stimulation/research (20%); and specifically for men, career (29%) and social prestige/recognition (26%). Heterogeneity within the same gender emerged. For example, the elements indicated by men as the most important were intellectual stimulation/research (39%) and work-life balance (21%) in general, versus social prestige/recognition (24%) and career (24%), respectively, specifically for men (p<0.0001). More women versus men perceived gender issue as an actual problem (60% vs 38%, p=0.03); men underestimated gender barriers to women's career (p=0.011). Conclusions: Satisfaction in professional abilities varied by gender. Work-life balance is important for both women and men. Stereotypes about gender issues may be present. Gender issue is an actual problem for young oncologists, mostly perceived by women

A Multi-Criteria Approach to the Evaluation of Aviation e-marketplace portals

After a proliferation of logistics e-Marketplaces during the dot.com boom of 1998-2000, there has been a high rate of failure and survivals are developing much more slowly than expected. This is the case of aviation industry where a large number of B2B e-Marketplaces emerged according to the focus of aviation companies’ strategies on electronic B2B in the late 1990s. However, the current use of e-Marketplaces in the industry is low and many of them have ceased trading. The traditional e-Marketplaces model have been characterised by poor quality of portals and the lack of technical standards. Such an approach is unsustainable in today’s competitive scenario. Improvements in websites quality attributes may strongly contribute to simplify the website functionalities by users and speed-up communication with all supply chain parties. In such context, it appears of critical importance to develop models for the evaluation of e-Marketplaces web sites. This paper, after a discussion about the development of e-Marketplaces in the transport and logistics service industry and its application in the aviation industry, proposes a multi-criteria model for assessing e-Marketplaces portals that has been subsequently applied to three different types of aeronautic B2B e-Marketplaces

Assessing Aviation E-Marketplaces: a Mmulti-Criteria Approach.

After a proliferation of logistics e-Marketplaces during the dot.com boom of 1998-2000, there has been a high rate of failure and survivals are developing much more slowly than expected. This is the case in the aviation industry where a large number of B2B e-Marketplaces emerged according to the focus of aviation companies’ strategies on electronic B2B in the late 1990s. However, the current use of e-Marketplaces in the industry is low and many of them have ceased trading. The traditional e-Marketplaces model has been characterised by poor quality portals and a lack of technical standards. Such an approach is unsustainable in today’s competitive scenario. Improvements in website quality attributes may strongly contribute to the simplification of website functionality by users and speed up communication with all supply chain partners. In this context, it appears critical to develop models for the evaluation of e-Marketplace web sites. This chapter, after a discussion about the development of e-Marketplaces in the transport and logistics service industry and its application in the aviation industry, proposes a multi-criteria model for assessing different types of aeronautic B2B e-Marketplaces

Effect of human chorionic gonadotrophin administration 2 days after insemination on progesterone concentration and pregnancy per artificial insemination in lactating dairy cows

peer-reviewedThe aim of this study was to examine the effect of a single administration of human chorionic gonadotrophin (hCG) during the establishment of the corpus luteum (CL) on progesterone (P4) concentration and pregnancy per artificial insemination (P/AI) in lactating dairy cows. Postpartum spring-calving lactating dairy cows (n = 800; mean ± SD days in milk and parity were 78.5 ± 16.7 and 2.3 ± 0.8, respectively) on 3 farms were enrolled on the study. All cows underwent the same fixed-time AI (FTAI) protocol involving a 7-d progesterone-releasing intravaginal device with gonadotrophin-releasing hormone (GnRH) administration at device insertion, prostaglandin at device removal followed by GnRH 56 h later, and AI 16 h after the second GnRH injection. Cows were blocked on days postpartum, body condition score, and parity and randomly assigned to receive either 3,000 IU of hCG 2 d after FTAI or no further treatment (control). Blood samples were collected on d 7 and 14 postestrus by coccygeal venipuncture on a subset of 204 cows to measure serum P4 concentration, and pregnancy was diagnosed by ultrasonography approximately 30 and 70 d after FTAI. Administration of hCG caused an increase in circulating P4 concentrations compared with the control treatment on d 7 (+22.2%) and d 14 (+25.7%). The P/AI at 30 d after FTAI was affected by treatment, farm, body condition score, and calving to service interval. Overall, administration of hCG decreased P/AI (46.3% vs. 55.1% for the control). Among cows that did not become pregnant following AI, a greater proportion of control cows exhibited a short repeat interval (≤17 d) compared with cows treated with hCG (8.6% vs. 2.8%, respectively). In addition, the percentages of cows pregnant at d 21 (59.6% vs. 52.0%) and d 42 (78.3% vs. 71.9%) were greater in control than in hCG-treated cows. The overall incidence of embryo loss was 10.7% and was not affected by treatment. There was a tendency for an interaction between treatment and CL status at synchronization protocol initiation for both P4 concentration and P/AI. In conclusion, administration of hCG 2 d after FTAI increased circulating P4 concentrations. Unexpectedly, cows treated with hCG had lower fertility; however, this negative effect on fertility was manifested primarily in cows lacking a CL at the onset of the synchronization protocol

La relación entre el uso de redes sociales y la procrastinación en universitarios

El uso de las redes sociales genera un impacto en las diferentes áreas de la vida de las personas, en especial en la de los estudiantes, por lo que es importante analizarlo. El objetivo de esta investigación es identificar la relación entre el uso de las redes sociales y la procrastinación a través de la creación de un reporte escrito basado en el análisis de estudios previos realizados en este ámbito durante los últimos 8 años. Teniendo en cuenta las indicaciones de la guía Prisma, se revisaron las bases de datos EBSCO, Proquest y Scopus, y tomando en consideración nuestros criterios de inclusión y exclusión, se llegó a un total de 10 estudios que mostraban la relación entre la variable “uso de redes sociales” y sus derivados, con la procrastinación en general y la académica. La mayoría de los resultados confirman la existencia de una relación significativamente positiva entre las variables en cuestión, así como la capacidad predictiva del uso de redes sociales en la procrastinación. Asimismo, se encontró variables mediadoras relacionadas a las dos principales variables. Se proponen recomendaciones prácticas en base a las implicancias y limitaciones.The use of social media generates an impact in different areas of the lives of people, especially the lives of students, and that is why it’s important to analyze it. The objective of this investigation is to identify the relationship between social media usage and procrastination through the creation of a written report based on the analysis of previous studies conducted in this field during the past 8 years. Keeping in mind the advice from the Prisma guide, the data bases EBSCO, Proquest and Scopus were reviewed, and considering our inclusion and exclusion criteria, we achieved a total of 10 articles that showed the relationship between the variable “social media usage” and its derivatives, with general and academic procrastination. Most of the results confirm the existence of a significantly positive relationship between the variables in question, just like the predictive capacity of social media usage in procrastination. Additionally, there were mediator variables related to both main variables. Practical recommendations are proposed based on the implications and limitations