Analysis Of Factors Related To Stunting Prevention In Children Aged 2-5 Years

Background: Nutritional status in Indonesia, especially stunting in toddlers, is still a problem that is influenced by many interrelated factors. This Study aimed to analyze the factors related to prevention of stunting in toddlers. Methods: This study used a cross-sectional design. The population was 131 mothers who have children aged 2-5 years at Timbulharjo village, Sewon, Bantul with number of samples are 57 people using purposive sampling technique. The independent variables were prior related behavior, education level, socio-economic status, perceived benefits to action and perceived barrier to action. Dependent variable was prevention of stunting. Data were collected using questionnaire and analyzed using logistic regression with a significance level α 0.05. Results: The vast majority (54.4%) of maternal education is high school (61.4%) with a family income of <1,790,500, most respondents have the benefit of perceived actions insufficient categories (56.1%). High prior related behavior was 1.26 times better at stunting prevention than low prior related behavior. Any change per 1 unit on the previous behavioral variable and a change per 1 unit on the benefit variable of the perceived action, will increase the likelihood of stunting prevention behavior (4.6%). Conclusion: Factors associated with stunting prevention behavior are prior related behavior and perceived benefit to action. The dominants factor related to stunting prevention behavior is prior related behavior. This research showed that it is able to add information and improve stunting prevention behavior for the community. This can be realized through collaboration with health workers to conduct integrated service program held an activities, training, workshop, and family mentoring related to stunting prevention

Pengaruh Ekstrak Kelakai (Stenochlaena palustris (Burm.f) Bedd) terhadap Kadar Interleukin-10 (IL-10) Mencit

Abstract : Interleukin-10 as pro-inflammatory cytokines have a role to protect the damage of severe malaria. Kelakai contain bioactive compounds that have anti-inflammatory activity. The purpose of this study was to determine the potential of the extract kelakai on levels of IL-10 in mice BALB / s infected by P. berghei ANKA. This study is true experimental studies with posttest-only with Control Group Design. The treatment group was divided into 8 groups. Two groups received kelakai extract per oral 10 mg/kgBW and 100 mg/kgBW. Four groups received kelakai extract per oral 10 mg/kgBW and 100 mg/kgBW 3 hours after infection and when the parasitaemia reaches 15-20%. Negative controls do not receive the extract kelakai and parasitic infections. Positive controls get a parasitic infection. Treatment was given for 4 days. Blood samples were taken 24 hours after the last treatment. Levels of IL-10 were measured by sandwich ELISA method. Data were analyzed with Games Howell test, with a confidence level of 95%. There were no significant differences between treatment groups. Extract kelakai Giving oral dose of 10 mg/KgBW and 100 mg/KgBW not significantly increase the levels of interleukin-10. Keywords: Stenochlaena palustris (Burm.f) bedd; Interleukin-10 Abstrak : Interleukin-10 sebagai Sitokin pro-inflamasi memiliki peran melindungi kerusakan pada malaria berat. Kelakai mengandung senyawa bioaktif yang mempunyai aktifitas anti-inflamasi. Tujuan penelitian ini adalah untuk mengetahui potensi ekstrak kelakai terhadap kadar IL-10 pada mencit BALB/s yang diinfeksi P. berghei ANKA. Penelitian ini merupakan studi eksperimental murni dengan Posttest-only with Control Group Design. Kelompok perlakuan dibagi menjadi 8 kelompok. Dua kelompok mendapat ekstrak kelakai per oral 10 mg/kg berat badan dan 100 mg/kg berat badan. Empat kelompok mendapat ekstrak kelakai per oral 10 mg/kg berat badan dan 100 mg/kg berat badan 3 jam setelah infeksi dan pada saat parasitemia mencapai 15-20%. Kontrol negatif tidak mendapat ekstrak kelakai dan infeksi parasit. Kontrol positif mendapat infeksi parasit. Perlakuan diberikan selama 4 hari. Sampel darah diambil 24 jam setelah perlakuan terakhir. Kadar Il-10 diukur dengan ELISA metode sandwich. Data dianalisa dengan tes Games Howell, dengan tingkat kepercayaan 95%. Tidak didapatkan perbedaan bermakna antar kelompok perlakuan. Pemberian Ekstrak kelakai secara oral dosis 10 mg/Kg berat badan dan 100 mg/Kg berat badan tidak signifikan meningkatkan kadar Interleukin-10. Kata-kata Kunci : Stenochlaena palustris (Burm.f) Bedd; Interleukin-1

POTENSI EKSTRAK KELAKAI (Stenochlaena palustris (Burm.f) Bedd) TERHADAP KADAR TNF-α dan IL-10 PADA MENCIT BALB/c YANG DIINFEKSI Plasmodium berghei ANKA

Malaria masih menjadi masalah kesehatan utama di dunia. Sitokin pro-inflamasi seperti TNF-α meningkat pada malaria berat. Sitokin anti-inflamasi, seperti IL-10 memiliki peran untuk melindungi terjadinya kerusakan. Keseimbangan antara produksi sitokin pro dan antiinflamasi mempengaruhi sistem pertahanan tubuh sebagai sesuatu yang penting untuk resolusi berbagai kondisi patologis. Di Kalimantan Selatan, tanaman kelakai digunakan untuk mengobati demam dan penyakit infeksi. Kelakai mengandung senyawa-senyawa bioaktif antara lain flavonoid, steroid, dan alkaloid yang dilaporkan memiliki banyak efek biologis, termasuk aktivitas anti-inflamasi. Tujuan penelitian ini adalah untuk mengetahui potensi ekstrak kelakai terhadap kadar TNF-α pada mencit BALB/s yang diinfeksi P. berghei ANKA. Penelitian ini merupakan studi eksperimental murni dengan Posttest-only with Control Group Design. Kelompok perlakuan dibagi menjadi 8 kelompok. Dua kelompok mendapat ekstrak kelakai per oral 10 mg/kg BB dan 100 mg/kg BB. Empat kelompok mendapat ekstrak kelakai per oral 10 mg/kg BB dan 100 mg/kg BB 3 jam setelah infeksi dan pada saat parasitemia mencapai 15-20%. Kontrol negatif tidak mendapat ekstrak kelakai dan infeksi parasit. Kontrol positif mendapat infeksi parasit. Perlakuan diberikan selama 4 hari. Sampel darah diambil 24 jam setelah perlakuan terakhir. Kadar TNF-α dan IL-10 diukur dengan ELISA metode sandwich. Data dianalisa dengan tes Games Howell, dengan tingkat kepercayaan 95%. Terdapat perbedaan bermakna antar kelompok perlakuan, nilai p = 0,000 (p<0,05). Ekstrak kelakai berpotensi menghambat produksi TNF-α pada kelompok Pb + EK10 5 hari (p = 0,005)

PENGARUH EKSTRAK KELAKAI (Stenochlaena palustris (Burm.f) Bedd) TERHADAP KADAR INTERLEUKIN-10 (IL-10) MENCIT

Abstract Abstract : Interleukin-10 as pro-inflammatory cytokines have a role to protect the damage of severe malaria. Kelakai contain bioactive compounds that have anti-inflammatory activity. The purpose of this study was to determine the potential of the extract kelakai on levels of IL-10 in mice BALB / s infected by P. berghei ANKA. This study is true experimental studies with posttest-only with Control Group Design. The treatment group was divided into 8 groups. Two groups received kelakai extract per oral 10 mg/kgBW and 100 mg/kgBW. Four groups received kelakai extract per oral 10 mg/kgBW and 100 mg/kgBW 3 hours after infection and when the parasitaemia reaches 15-20%. Negative controls do not receive the extract kelakai and parasitic infections. Positive controls get a parasitic infection. Treatment was given for 4 days. Blood samples were taken 24 hours after the last treatment. Levels of IL-10 were measured by sandwich ELISA method. Data were analyzed with Games Howell test, with a confidence level of 95%. There were no significant differences between treatment groups. Extract kelakai Giving oral dose of 10 mg/KgBW and 100 mg/KgBW not significantly increase the levels of interleukin-10. Keywords: Stenochlaena palustris (Burm.f) bedd; Interleukin-10 Abstrak : Interleukin-10 sebagai Sitokin pro-inflamasi memiliki peran melindungi kerusakan pada malaria berat. Kelakai mengandung senyawa bioaktif yang mempunyai aktifitas anti-inflamasi. Tujuan penelitian ini adalah untuk mengetahui potensi ekstrak kelakai terhadap kadar IL-10 pada mencit BALB/s yang diinfeksi P. berghei ANKA. Penelitian ini merupakan studi eksperimental murni dengan Posttest-only with Control Group Design. Kelompok perlakuan dibagi menjadi 8 kelompok. Dua kelompok mendapat ekstrak kelakai per oral 10 mg/kg berat badan dan 100 mg/kg berat badan. Empat kelompok mendapat ekstrak kelakai per oral 10 mg/kg berat badan dan 100 mg/kg berat badan 3 jam setelah infeksi dan pada saat parasitemia mencapai 15-20%. Kontrol negatif tidak mendapat ekstrak kelakai dan infeksi parasit. Kontrol positif mendapat infeksi parasit. Perlakuan diberikan selama 4 hari. Sampel darah diambil 24 jam setelah perlakuan terakhir. Kadar Il-10 diukur dengan ELISA metode sandwich. Data dianalisa dengan tes Games Howell, dengan tingkat kepercayaan 95%. Tidak didapatkan perbedaan bermakna antar kelompok perlakuan. Pemberian Ekstrak kelakai secara oral dosis 10 mg/Kg berat badan dan 100 mg/Kg berat badan tidak signifikan meningkatkan kadar Interleukin-10. Kata-kata Kunci : Stenochlaena palustris (Burm.f) Bedd; Interleukin-1