Additional file 1: of A comparison of multiple imputation methods for handling missing values in longitudinal data in the presence of a time-varying covariate with a non-linear association with time: a simulation study

Supplementary Material. (DOCX 550 kb

Number (%) of waves with available hormone measurements for each hormone for females and males.

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Linear mixed-effect models for saliva hormones.

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Number (%) of females and males in cross-classifications of individuals by hormone level at age 9 years and hormone progression rate over time.

L1, L2, and L3 respectively indicate low, normal, and high predicted hormone levels compared to population; R1 and R2 indicate slow/normal and fast predicted progression rate over time compared to population.</p

Estimates of standard deviation and correlation parameters in the mixed-effects models for adrenal hormone measured at age 9 years old.

Estimates of standard deviation and correlation parameters in the mixed-effects models for adrenal hormone measured at age 9 years old.</p

Percentage of individuals who changed class after excluding hormone measurements collected after 11am (n = 51).

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Estimates of fixed-effect coefficients, with 95% confidence intervals, in the mixed-effects models.

Estimates of fixed-effect coefficients, with 95% confidence intervals, in the mixed-effects models.</p

Descriptive statistics for age at saliva collection, time of saliva collection, saliva flow rate, and hormone measurements at waves 1 to 4 for females (n = 667) and males (n = 572).

Descriptive statistics for age at saliva collection, time of saliva collection, saliva flow rate, and hormone measurements at waves 1 to 4 for females (n = 667) and males (n = 572).</p

Histogram of log detectable values for DHEA-S overlaid with a normal distribution curve.

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Percentage of individuals who changed class after excluding hormone measurements not collected at school setting (n = 149).

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