The Mexican Mural Movement 1900-1930

Many studies have been made of the 'Mexican Mural Renaissance', but these generally have not provided an integrated account of the philosophical and ideological beginnings, development and end of the Mexican government's 1920's programme. Also, recent studies dealing with aspects of the programme have brought new evidence forward which allows this study to provide an overview of the social, political and aesthetic context of the mural programme. This is helpful in the assessment of the muralists' artistic achievements both as individuals and as members of the artists' syndicate. Primary source material such as the artists' autobiographies and the newspapers such as 'La Vanguardia' and 'EI Machete' to which they frequently contributed have also been studied closely to provide new insights into their political thinking and aesthetic principles as they sought to create a 'revolutionary art for all.' Since the programme was government-sponsored as part of a national education policy, the ideology of the regimes which preceded and followed the Revolution of 1910-17 has been examined to ascertain how well the muralists' ideals and work matched the expectations of their official patrons. Accordingly an account is also given of the political life of Mexico, in particular during the dictatorship of Porfirio Diaz and the Revolution, and especially close attention is given to politics during the 1920's when the mural programme was underway. Concerning the muralists themselves, aspects of their experience which may have influenced their art are considered concurrently with their contemporary work. This is particularly important as a major question addressed in this study concerns the reduction of the muralists' programme from a group project, to the efforts of three noted muralists with assistance in some cases from others previously employed as muralists in their own right, to the final reduction of the programme to just Diego Rivera and several assistants

Lattice polytopes from Schur and symmetric Grothendieck polynomials

Given a family of lattice polytopes, two common questions in Ehrhart Theory are determining when a polytope has the integer decomposition property and determining when a polytope is reflexive. While these properties are of independent interest, the confluence of these properties is a source of active investigation due to conjectures regarding the unimodality of the $h^\ast$-polynomial. In this paper, we consider the Newton polytopes arising from two families of polynomials in algebraic combinatorics: Schur polynomials and inflated symmetric Grothendieck polynomials. In both cases, we prove that these polytopes have the integer decomposition property by using the fact that both families of polynomials have saturated Newton polytope. Furthermore, in both cases, we provide a complete characterization of when these polytopes are reflexive. We conclude with some explicit formulas and unimodality implications of the $h^\ast$-vector in the case of Schur polynomials.Comment: 37 pages, 3 tables, 4 figures; Comments Welcome; Version 2: updated references to acknowledge one result was previously known, corrected values in Table 1 and reference correct OEIS sequence; Version 3: Final Version. To appear in Electronic Journal of Combinatoric

The fifth adaptor protein complex.

Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. Four distinct AP complexes have been identified, which are present in most eukaryotes. We report the existence of a fifth AP complex, AP-5. Tagged AP-5 localises to a late endosomal compartment in HeLa cells. AP-5 does not associate with clathrin and is insensitive to brefeldin A. Knocking down AP-5 subunits interferes with the trafficking of the cation-independent mannose 6-phosphate receptor and causes the cell to form swollen endosomal structures with emanating tubules. AP-5 subunits can be found in all five eukaryotic supergroups, but they have been co-ordinately lost in many organisms. Concatenated phylogenetic analysis provides robust resolution, for the first time, into the evolutionary order of emergence of the adaptor subunit families, showing AP-3 as the basal complex, followed by AP-5, AP-4, and AP-1 and AP-2. Thus, AP-5 is an evolutionarily ancient complex, which is involved in endosomal sorting, and which has links with hereditary spastic paraplegia

Exercise prescription improves exercise tolerance in young children with CHD:a randomised clinical trial

Objective The main objective of this study was to ascertain if a structured intervention programme can improve the biophysical health of young children with congenital heart disease (CHD). The primary end point was an increase in measureable physical activity levels following the intervention.Methods Patients aged 5–10 years with CHD were identified and invited to participate. Participants completed a baseline biophysical assessment, including a formal exercise stress test and daily activity monitoring using an accelerometer. Following randomisation, the intervention group attended a 1 day education session and received an individual written exercise plan to be continued over the 4-month intervention period. The control group continued with their usual level of care. After 4 months, all participants were reassessed in the same manner as at baseline.Results One hundred and sixty-three participants (mean age 8.4 years) were recruited, 100 of whom were male (61.3%). At baseline, the majority of the children were active with good exercise tolerance. The cyanotic palliated subgroup participants, however, were found to have lower levels of daily activity and significantly limited peak exercise performance compared with the other subgroups. One hundred and fifty-two participants (93.2%) attended for reassessment. Following the intervention, there was a significant improvement in peak exercise capacity in the intervention group. There was also a trend towards increased daily activity levels.Conclusion Overall physical activity levels are well preserved in the majority of young children with CHD. A structured intervention programme significantly increased peak exercise capacity and improved attitudes towards positive lifestyle changes

The temporal relationship between local school closure and increased incidence of pediatric diabetic ketoacidosis

IMPORTANCE: The incidence of pediatric diabetic ketoacidosis (DKA) increased early in the COVID-19 pandemic, but the relative contribution of behavioral changes and viral-related pathophysiology are unknown. OBJECTIVE: To evaluate the relationship between school closure date and onset of increased DKA to help clarify the etiology of the increased incidence. DESIGN: A multi-center, quality-controlled Pediatric Intensive Care Unit (PICU) database was used to identify the number of admissions to a participating PICU with DKA on each calendar day from 60 days before local school closure to 90 days after, and compared to baseline data from the same periods in 2018-2019. Interrupted time series and multiple linear regression analyses were used to identify admission rates that differed significantly between 2020 and baseline. SETTING: Eighty-one PICUs in the United StatesParticipants: Children ages 29 days to 17 years admitted to a PICU with DKAExposures: Statewide school closureMain outcome/measure: Rate of admission to the PICU for DKA. RESULTS: There were 1936 admissions for children with DKA in 2020 and 1795 admissions/year to those same PICUs in 2018-2019. Demographics and clinical outcomes did not differ before school closure, but pandemic-era patients were less often white and had longer hospital length of stay in the post-school closure period. The difference between 2020 admissions and 2018-2019 admissions was not different than zero before school closure, and significantly higher than zero after school closure, but was significantly increased in 2020 at \u3e30 days after school closure ( CONCLUSIONS/RELEVANCE: An increase in pediatric DKA admissions began one month after school closures. Given that behavioral changes started near school closure dates and viral activity peaked weeks after, this suggests that behavioral factors may not be the primary etiology and it is possible that SARS-CoV-2 infection may have direct effects on pediatric DKA

Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma

<p>Abstract</p> <p>Background</p> <p>Metastatic melanoma is an incurable disease with an average survival of less than one year. Talabostat is a novel dipeptidyl peptidase inhibitor with immunostimulatory properties.</p> <p>Methods</p> <p>This phase II, open label, single arm study was conducted to evaluate the safety and efficacy of 75–100 mg/m²cisplatin combined with 300–400 mcg talabostat bid for 6, 21-day cycles. The primary endpoint was overall response. The rate of complete responses, duration of overall objective response, progression-free survival (PFS), and overall survival were the secondary endpoints.</p> <p>Results</p> <p>Six objective partial responses were recorded in the 74 patients (8.1%) in the intention-to-treat population. Five of these responses involved the 40 evaluable patients (12.5%). Thirty-one percent of patients reported SAEs to the combination of talabostat and cisplatin.</p> <p>Conclusion</p> <p>Acceptable tolerability was observed in the intention-to-treat population and antitumor activity was observed in 12.5% of evaluable patients, which is not greater than historical expectation with cisplatin alone.</p