A Bilingual Thesaurus of Everyday Life in Medieval England: Some Issues at the Interface of Semantics and Lexicography

This paper reports on issues at the interface between semantics and lexicography that arose out of the data collection and classification of vocabulary in Anglo-Norman and Middle English in order to create a bilingual thesaurus of everyday life in medieval England. The Bilingual Thesaurus project is based at Birmingham City University and the University of Westminster. Issues to be resolved included the definition of an occupational domain; the creation of a methodology of data collection; the delimitation of domain-specific vocabulary; making distinctions between sense and usage; and the categorisation of the lexical items. Some of these issues are general to thesaurus-making, some are specific to the making of historical thesauruses, while some are unique to the production of a thesaurus of two languages whose use overlapped for several centuries in the late medieval period in England

Lone other-language items in later medieval texts

This paper addresses the use in medieval texts of ‘lone other-language items’ (Poplack and Dion 2012), considering their status as loans or code-switches (Durkin 2014; Schendl and Wright 2011). French-origin and English-origin lexemes in Middle English, respectively, were taken from the Bilingual Thesaurus of Everyday Life in Medieval England, a source of loan words chosen for its sociolinguistic representativeness and studied via Middle English Dictionary citations and textbase occurrences. Four criteria were applied for whether they should be treated as code-switches or as loans: the textual context in which the item appears, the adoption of target language verbal morphology, the length of attestation within the target language of individual lexical items (Matras 2009), and the integration of items into the syntactic structure of nominal phrases in conflict sites for code-switching (Poplack et al. 2015). Results provide little support for code-switching as the channel for the integration of lone other-language items, suggesting rather that individual items of foreign origin were immediately borrowed, consistently with Poplack and Dion’s (2012) treatment of contemporary contact phenomena

Physical activity as an aid to smoking cessation during pregnancy: Two feasibility studies

Background: Pharmacotherapies for smoking cessation have not been adequately tested in pregnancy and women are reluctant to use them. Behavioural support alone has a modest effect on cessation rates; therefore, more effective interventions are needed. Even moderate intensity physical activity (e.g. brisk walk) reduces urges to smoke and there is some evidence it increases cessation rates in non-pregnant smokers. Two pilot studies assessed i) the feasibility of recruiting pregnant women to a trial of physical activity for smoking cessation, ii) adherence to physical activity and iii) womens' perceptions of the intervention. Methods: Pregnant smokers volunteered for an intervention combining smoking cessation support, physical activity counselling and supervised exercise (e.g. treadmill walking). The first study provided six weekly treatment sessions. The second study provided 15 sessions over eight weeks. Physical activity levels and continuous smoking abstinence (verified by expired carbon monoxide) were monitored up to eight months gestation. Results: Overall, 11.6% (32/277) of women recorded as smokers at their first antenatal booking visit were recruited. At eight months gestation 25% (8/32) of the women achieved continuous smoking abstinence. Abstinent women attended at least 85% of treatment sessions and 75% (6/8) achieved the target level of 110 minutes/week of physical activity at end-of-treatment. Increased physical activity was maintained at eight months gestation only in the second study. Women reported that the intervention helped weight management, reduced cigarette cravings and increased confidence for quitting. Conclusion: It is feasible to recruit pregnant smokers to a trial of physical activity for smoking cessation and this is likely to be popular. A large randomised controlled trial is needed to examine the efficacy of this intervention

Ground state spin and Coulomb blockade peak motion in chaotic quantum dots

We investigate experimentally and theoretically the behavior of Coulomb blockade (CB) peaks in a magnetic field that couples principally to the ground-state spin (rather than the orbital moment) of a chaotic quantum dot. In the first part, we discuss numerically observed features in the magnetic field dependence of CB peak and spacings that unambiguously identify changes in spin S of each ground state for successive numbers of electrons on the dot, N. We next evaluate the probability that the ground state of the dot has a particular spin S, as a function of the exchange strength, J, and external magnetic field, B. In the second part, we describe recent experiments on gate-defined GaAs quantum dots in which Coulomb peak motion and spacing are measured as a function of in-plane magnetic field, allowing changes in spin between N and N+1 electron ground states to be inferred.Comment: To appear in Proceedings of the Nobel Symposium 2000 (Physica Scripta

Tectonic Geomorphology and Volcano-Tectonic Interaction in the Eastern Boundary of the Southern Cascades (Hat Creek Graben Region), California, USA

The eastern boundary of the Southern Cascades (Hat Creek Graben region), California, USA, is an extensively faulted volcanic corridor between the Cascade Range and Modoc Plateau. The morphology of the region is a result of plate motions associated with different tectonic provinces, faulting, and recurring volcanic activity, making it an ideal place to study the interrelationship between tectonics, volcanoes, and geomorphology. We use the morphometry and spatial distribution of volcanoes and their interaction with regional structures to understand howlong termregional deformation can affect volcano evolution. Adatabase of volcanic centers and structures was created frominterpretations of digital elevation models. Volcanic centers were classified by morphological type into cones, sub-cones, shields and massifs. A second classification by height separated the larger and smaller edifices, and revealed an evolutionary trend. Poisson Nearest Neighbor analysis showed that bigger volcanoes are spatially dispersed while smaller ones are clustered. Using volcano centroid locations, about 90 lineaments consisting of at least three centers within 6 km of one another were found, revealing that preferential north-northwest directedpathways control the transport of magma fromthe source to the surface, consistent with the strikes of the major fault systems. Most of the volcano crater and collapse scar openings are perpendicular to the north northwest-directed maximum horizontal stress, expected for extensional environments with dominant normal faulting. Early in the history of a volcano or volcano cluster, melt propagates to the surface using the easiest and most efficient pathway, mostly controlled by the pre-existing normal faults and near-surface stress fields, as indicated by the pervasive vent alignments. Volcano growth continues to be dependent on the regional structures as indicated by the opening directions, suggesting structural control on the growth of the volcanic edifices. The results present a particularly well-defined case in which extension of a volcanic region is accommodated mostly by faulting, and only partly by intrusion to formvolcanoes. This is attributed to a low magma supply rate.</p

Withania somnifera Root Extract Inhibits Mammary Cancer Metastasis and Epithelial to Mesenchymal Transition

Though clinicians can predict which patients are at risk for developing metastases, traditional therapies often prove ineffective and metastatic disease is the primary cause of cancer patient death; therefore, there is a need to develop anti-metastatic therapies that can be administered over long durations to specifically inhibit the motility of cancer cells. Withania somnifera root extracts (WRE) have anti-proliferative activity and the active component, Withaferin A, inhibits the pro-metastatic protein, vimentin. Vimentin is an intermediate filament protein and is part of the epithelial to mesenchymal transition (EMT) program to promote metastasis. Here, we determined whether WRE standardized to Withaferin A (sWRE) possesses anti-metastatic activity and whether it inhibits cancer motility via inhibition of vimentin and the EMT program. Several formulations of sWRE were created to enrich for Withaferin A and a stock solution of sWRE in EtOH could recover over 90% of the Withaferin A found in the original extract powder. This sWRE formulation inhibited breast cancer cell motility and invasion at concentrations less than 1μM while having negligible cytotoxicity at this dose. sWRE treatment disrupted vimentin morphology in cell lines, confirming its vimentin inhibitory activity. To determine if sWRE inhibited EMT, TGF-β was used to induce EMT in MCF10A human mammary epithelial cells. In this case, sWRE prevented EMT induction and inhibited 3-D spheroid invasion. These studies were taken into a human xenograft and mouse mammary carcinoma model. In both models, sWRE and Withaferin A showed dose-dependent inhibition of tumor growth and metastatic lung nodule formation with minimal systemic toxicity. Taken together, these data support the hypothesis that low concentrations of sWRE inhibit cancer metastasis potentially through EMT inhibition. Moreover, these doses of sWRE have nearly no toxicity in normal mouse organs, suggesting the potential for clinical use of orally administered WRE capsules. © 2013 Yang et al

All Two-Loop MHV Amplitudes in Multi-Regge Kinematics From Applied Symbology

Recent progress on scattering amplitudes has benefited from the mathematical technology of symbols for efficiently handling the types of polylogarithm functions which frequently appear in multi-loop computations. The symbol for all two-loop MHV amplitudes in planar SYM theory is known, but explicit analytic formulas for the amplitudes are hard to come by except in special limits where things simplify, such as multi-Regge kinematics. By applying symbology we obtain a formula for the leading behavior of the imaginary part (the Mandelstam cut contribution) of this amplitude in multi-Regge kinematics for any number of gluons. Our result predicts a simple recursive structure which agrees with a direct BFKL computation carried out in a parallel publication.Comment: 20 pages, 2 figures. v2: minor correction