877 research outputs found
Monte Carlo Simulation of 2-D Quantum Gravity as Open Dynamically Triangulate Random Surfaces
We describe a Monte Carlo procedure for the simulation of dynamically
triangulate random surfaces with a boundary (topology of a disk). The algorithm
keeps the total number of triangles fixed, while the length of the boundary is
allowed to fluctuate. The algorithm works in the presence of matter fields. We
here present results for the pure gravity case. The algorithm reproduces the
theoretical expectations.Comment: LaTeX file, 16 pages, 7 LaTeX figures, preprints CERN-TH.7028/93,
MS-TPI-93-0
4U 1626-67 as seen by Suzaku before and after the 2008 torque reversal
Aims. The accretion-powered pulsar 4U 1626-67 experienced a new torque
reversal at the beginning of 2008, after about 18 years of steadily spinning
down. The main goal of the present work is to study this recent torque reversal
that occurred in 2008 February.
Methods. We present a spectral analysis of this source using two pointed
observations performed by Suzaku in 2006 March and in 2010 September.
Results. We confirm with Suzaku the presence of a strong emission-line
complex centered on 1 keV, with the strongest line being the hydrogen-like Ne
Ly-alpha at 1.025(3) keV. We were able to resolve this complex with up to seven
emission lines. A dramatic increase of the intensity of the Ne Ly-alpha line
after the 2008 torque reversal occurred, with the equivalent width of this line
reaching almost the same value measured by ASCA in 1993. We also report on the
detection of a cyclotron line feature centered at ~37 keV. In spite of the fact
that an increase of the X-ray luminosity (0.5-100 keV) of a factor of ~2.8
occurred between these two observations, no significant change in the energy of
the cyclotron line feature was observed. However, the intensity of the ~1 keV
line complex increased by an overall factor of ~8.
Conclusions. Our results favor a scenario in which the neutron star in 4U
1626-67 accretes material from a geometrically thin disk during both the
spin-up and spin-down phases.Comment: 7 pages, 5 figures and 2 tables. Accepted in A&
Multiple cyclotron line-forming regions in GX 301-2
We present two observations of the high-mass X-ray binary GX 301-2 with
NuSTAR, taken at different orbital phases and different luminosities. We find
that the continuum is well described by typical phenomenological models, like a
very strongly absorbed NPEX model. However, for a statistically acceptable
description of the hard X-ray spectrum we require two cyclotron resonant
scattering features (CRSF), one at ~35 keV and the other at ~50 keV. Even
though both features strongly overlap, the good resolution and sensitivity of
NuSTAR allows us to disentangle them at >=99.9% significance. This is the first
time that two CRSFs are seen in GX 301-2. We find that the CRSFs are very
likely independently formed, as their energies are not harmonically related
and, if it were a single line, the deviation from a Gaussian shape would be
very large. We compare our results to archival Suzaku data and find that our
model also provides a good fit to those data. We study the behavior of the
continuum as well as the CRSF parameters as function of pulse phase in seven
phase bins. We find that the energy of the 35 keV CRSF varies smoothly as
function of phase, between 30-38 keV. To explain this variation, we apply a
simple model of the accretion column, taking the altitude of the line-forming
region, the velocity of the in-falling material, and the resulting relativistic
effects into account. We find that in this model the observed energy variation
can be explained simply due to a variation of the projected velocity and
beaming factor of the line forming region towards us.Comment: 18 pages, 10 figures, accepted for publication in A&
The Sine Gordon Model: Perturbation Theory and Cluster Monte Carlo
We study the expansion of the surface thickness in the 2-dimensional lattice
Sine Gordon model in powers of the fugacity z. Using the expansion to order
z**2, we derive lines of constant physics in the rough phase. We describe and
test a VMR cluster algorithm for the Monte Carlo simulation of the model. The
algorithm shows nearly no critical slowing down. We apply the algorithm in a
comparison of our perturbative results with Monte Carlo data.Comment: compressed and uuencoded PostScript file, 25 pages, preprints CERN
TH.7374/94, MS-TPI-94-
IKKα modulates oxidative stress-induced DNA damage and repair in primary human OA chondrocytes
Spinning-Up: The Case of the Symbiotic X-Ray Binary 3A 1954+319
We present a timing and spectral analysis of the variable X-ray source 3A 1954+319, Our analysis is mainly based on an outburst serendipitously observed during INTEGRAL Key Program observations of the Cygnus region in 2008 fall and on the Swift/BAT longterm light curve, Previous observations, though sparse, have identified the source to be one of only nine known symbiotic X-ray binaries, i.e., systems composed of an accreting neutron star orbiting in a highly inhomogeneous medium around an M-giant companion. The spectrum of 3A 1954+319 above 20 keY can be best described by a broken power law model. The extremely long pulse period of approx.5.3 hours is clearly visible in the INTEGRAL/ISGRI light curve and confirmed through an epoch folding period search. Furthermore, the light curve allows us to determine a very strong spin up of -2x10(exp 4)h/h during the outburst. This spin up is confirmed by the pulse period evolution calculated from Swift/BAT data. The Swift/BAT data also show a long spin-down trend prior to the 2008 outburst. which is confirmed in archival INTEGRAL/ISGRI data. We discuss possible accretion models and geometries allowing for the transfer of such large amounts of angular momentum and investigate the harder spectrum of this outburst compared to previously published results
Cyclotron resonant scattering feature simulations. I. Thermally averaged cyclotron scattering cross sections, mean free photon-path tables, and electron momentum sampling
Electron cyclotron resonant scattering features (CRSFs) are observed as
absorption-like lines in the spectra of X-ray pulsars. A significant fraction
of the computing time for Monte Carlo simulations of these quantum mechanical
features is spent on the calculation of the mean free path for each individual
photon before scattering, since it involves a complex numerical integration
over the scattering cross section and the (thermal) velocity distribution of
the scattering electrons.
We aim to numerically calculate interpolation tables which can be used in
CRSF simulations to sample the mean free path of the scattering photon and the
momentum of the scattering electron. The tables also contain all the
information required for sampling the scattering electron's final spin.
The tables were calculated using an adaptive Simpson integration scheme. The
energy and angle grids were refined until a prescribed accuracy is reached. The
tables are used by our simulation code to produce artificial CRSF spectra. The
electron momenta sampled during these simulations were analyzed and justified
using theoretically determined boundaries.
We present a complete set of tables suited for mean free path calculations of
Monte Carlo simulations of the cyclotron scattering process for conditions
expected in typical X-ray pulsar accretion columns (0.01<B/B_{crit}<=0.12,
where B_{crit}=4.413x10^{13} G and 3keV<=kT<15keV). The sampling of the tables
is chosen such that the results have an estimated relative error of at most
1/15 for all points in the grid. The tables are available online at
http://www.sternwarte.uni-erlangen.de/research/cyclo.Comment: A&A, in pres
217 MECHANISMS OF ACTION OF ESE1, A NOVEL TRANSCRIPTIONAL REGULATOR OF CARTILAGE REMODELING, IN MMP-13 REGULATION
Ischemic preconditioning (IPC) limits myocardial infarct size through the activation of the PI3K-Akt signal cascade; however, little is known about the roles of individual PI3K isoforms in cardioprotection. We aimed, therefore, to elucidate the role of the PI3K alpha isoform in cardioprotection Pharmacological PI3K alpha inhibition was assessed in isolated-perfused mouse hearts subjected to ischemia/reperfusion injury (IRI), either during the IPC procedure or at reperfusion. PI3K alpha inhibition abrogated the IPC-induced protective effect at reperfusion, but not when given only during the IPC protocol. These results were confirmed in an in vivo model. Moreover, pharmacological PI3K alpha activation by insulin at reperfusion was sufficient to confer cardioprotection against IRI. In addition, PI3K alpha was shown to be expressed and activated in mouse cardiomyocytes, mouse cardiac endothelial cells, as well as in mouse and human heart tissue. Furthermore, PI3K alpha was shown to mediate its effect though the inhibition of mitochondrial permeability transition pore opening. In conclusion, PI3K alpha activity is required during the early reperfusion phase to reduce myocardial infarct size. This suggests that strategies specifically enhancing the alpha isoform of PI3K at reperfusion promote tissue salvage and as such, and could provide a direct target for clinical treatment of IRI.Fundacion Rafael del Pino
FONDECYT
3160298
British Heart Foundation
Cancer Research UK
C23338/A15965
UK NIHR University College London Hospitals Biomedical Research Centr
Products of a reciprocal chromosome translocation involving the c-myc gene in a murine plasmacytoma.
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