Flavonoid-enriched plant-extract-loaded emulsion: a novel phytocosmetic sunscreen formulation with antioxidant properties

The aim of this study was to develop a phytocosmetic sunscreen emulsion with antioxidant effect, containing a blend of flavonoid-enriched plant extracts. In vitro sun protection factor, antioxidant activity, skin irritation, photostability, cutaneous permeation, and retention of flavonoids were evaluated. Thermodynamically stable emulsions were obtained and tested for sensorial analysis after loading the blend of extracts. The selected emulsion was stable when stored at low temperatures (5 C), for which after 120 days the concentration of quercetin and rutin were above their limit of quantification, i.e., 2.8 ± 0.39 µg/mL and 30.39 ± 0.39 µg/mL, respectively. Spreadability, low rupture strength and adhesiveness were shown to be similar to a conventional topical product. Higher brittleness, pseudo-plastic, and viscoelastic behaviors were also recorded for the developed phytocosmetic sunscreen. The product presented a critical wavelength of 387.0 nm and ultraviolet rays A and B (UVA/UVB) rate of 0.78, confirming that the developed formulation shows capacity for UVA/UVB protection, protecting skin against damages caused by Ultraviolet (UV) radiation. Rutin was shown to permeate the skin barrier and was also quantified in the stratum corneum (3.27 ± 1.92 µg/mL) by tape stripping and retention test (114.68 ± 8.70 µg/mL). The developed flavonoid-enriched phytocosmetic was shown to be non-irritant to skin by an in vitro assay. Our results confirm the antioxidant activity, sun protection, and physical properties of the developed phytocosmetic for topical application.This research was funded by FAPESP (grant number 2015/25533‐7 and 2017/14757‐7), CAPES and CNPq. The authors also received support from the Portuguese Science and Technology Foundation (FCT/MCT) and from European Funds (PRODER/COMPETE) under the project reference M‐ERA‐NET/0004/2015‐PAIRED, co‐financed by FEDER, under the Partnership Agreement PT2020, and PhD scholarship (SFRH/BD/130555/2017).info:eu-repo/semantics/publishedVersio

Incorporation of molecularly imprinted polymer nanoparticles in electrospun polycaprolactone fibers

Polymers synthesized by molecular imprinting technology are commonly known as molecularly imprinted polymers (MIP). In this work, nanoparticles of MIP for β-caryophyllene (NP-MIP-βCP) were synthesized and incorporated into poly (ε-caprolactone) PCL fibers by electrospinning, where morphological characterization was performed by SEM and average diameter of 129 ± 32.3 nm was found. Also, PCL electrospun fiber diameters without and with nanoparticles were 1.66 ± 1.12 and 0.70 ± 0.24 µm, respectively. Chemical characterization by infrared spectroscopy (FTIR) confirmed the synthesis of the NP-MIP-βCP and vibrational band present at 1628 cm−1 indicates the insertion of the NP-MIP-βCP into PCL fibers. It was found the influence of the incorporation of NP-MIP-βCP in thermal and tensile properties of the PCL electrospun membrane. Therefore, NP-MIP-βCP can be incorporated in PCL electrospun membranes by electrospinning and presents a potential application in the pharmaceutical and biomedicine areas, and biosensors275CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO AMAZONAS - FAPEAM308660/2015-3; 421745/2016-9Não te

In vitro and in vivo evaluation of electrospun membranes of poly (ε-caprolactone) and poly (rotaxane)

Sem informação77912919CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP308660/2015-3; 401297/2014-41995535/15055-