A ranking of the value of patents granted by legal protection

This paper aims at ranking the value of legal patent protection among countries, using the real options approach. In particular, we manage to overcome the problem of the lack of data for those countries that do not collect patent renewal data. The econometric technique we propose is well grounded in economic theory, specifically in the real options literature. Following this estimation strategy, we rank the value of legal patent protection for seventeen countries, closely reproducing other rankings based on surveys, for instance the PatVal survey by the EU Commission (2006), but relying on macro data publicly available and easy to access.Legal protection, intellectual property, real option, value of patent.

Collective behavior of oscillating electric dipoles

The present work reports about the dynamics of a collection of randomly distributed, and randomly oriented, oscillators in 3D space, coupled by an interaction potential falling as $1/r^3$, where r stands for the inter-particle distance. This model schematically represents a collection of identical biomolecules, coherently vibrating at some common frequency, coupled with a $1/r^3$ potential stemming from the electrodynamic interaction between oscillating dipoles. The oscillating dipole moment of each molecule being a direct consequence of its coherent (collective) vibration. By changing the average distance among the molecules, neat and substantial changes in the power spectrum of the time variation of a collective observable are found. As the average intermolecular distance can be varied by changing the concentration of the solvated molecules, and as the collective variable investigated is proportional to the projection of the total dipole moment of the model biomolecules on a coordinate plane, we have found a prospective experimental strategy of spectroscopic kind to check whether the mentioned intermolecular electrodynamic interactions can be strong enough to be detectable, and thus to be of possible relevance to biology.Comment: 20 pages, 4 figure

Design and Bench-Scale Hydrodynamic Testing of Thin-Layer Wavy Photobioreactors

In a thin-volume photobioreactor where a concentrated suspension of microalgae is circulated throughout the established spatial irradiance gradient, microalgal cells experience a time-variable irradiance. Deploying this feature is the most convenient way of obtaining the so-called flashing light effect, improving biomass production in high irradiance. This work investigates the light flashing features of sloping wavy photobioreactors, a recently proposed type, by introducing and validating a computational fluid dynamics (CFD) model. Two characteristic flow zones (straight top-to-bottom stream and local recirculation stream), both effective toward light flashing, have been found and characterized: a recirculation-induced frequency of 3.7 Hz and straight flow-induced frequency of 5.6 Hz were estimated. If the channel slope is increased, the recirculation area becomes less stable while the recirculation frequency is nearly constant with flow rate. The validated CFD model is a mighty tool that could be reliably used to further increase the flashing frequency by optimizing the design, dimensions, installation, and operational parameters of the sloping wavy photobioreactor

Spectroscopy of 10 gamma-ray BL Lac objects at high redshift

We present high S/N optical spectra of 10 BL Lac objects detected at GeV energies by Fermi satellite (3FGL catalog), for which previous observations suggested that they are at relatively high redshift. The new observations, obtained at the 10 m Gran Telescopio Canarias, allowed us to find the redshift for J0814.5+2943 (z = 0.703) and we can set spectroscopic lower limit for J0008.0+4713 (z>1.659) and J1107.7+0222 (z>1.0735) on the basis of Mg II intervening absorption features. In addition we confirm the redshifts for J0505.5+0416 (z=0.423) and for J1450+5200 (z>2.470). Finally we contradict the previous z estimates for five objects (J0049.7+0237, J0243.5+7119, J0802.0+1005, J1109.4+2411, and J2116.1+3339).Comment: 10 pages, 2 figures, 4 tables; accepted for publication in Ap

On the redshift of the very high energy {\gamma}-ray BL Lac object S2 0109+22

The determination of the redshift of extragalactic gamma ray sources is of fundamental importance for the interpretation of their emission models and extragalactic population studies, AGN classification schemes, and to study the interaction with the extragalactic background light. Here we focus on the BL Lac S2 0109+22, recently detected at very high energies. We obtained a high signal-to-noise optical spectrum at Gran Telescopio Canarias for the source over the spectral range 4000-10000 Angstrom, to search for spectral features of the host galaxy and/or of the nuclear source and it was compared with previous observations in order to confirm and/or dispute its redshift determination. We find the S2 0109+22 optical spectrum is well represented by a power law continuum without any absorption or emission feature of Equivalent Width >0.1 Angstrom. Based on the new optical spectrum we are able to set a redshift lower limit z>0.35, assuming the source is hosted by a massive elliptical galaxy typical for this class of sources. The redshift z=0.265 proposed in the literature for this object is most probably referred to a r=18.3 galaxy at 15" from S2 0109. This galaxy could belong to a group of faint galaxies located at z~0.26.Comment: 5 pages, 5 figures; accepted on MNRA

Physics-based large-signal sensitivity analysis of microwave circuits using technological parametric sensitivity from multidimensional semiconductor device models

The authors present an efficient approach to evaluate the large-signal (LS) parametric sensitivity of active semiconductor devices under quasi-periodic operation through accurate, multidimensional physics-based models. The proposed technique exploits efficient intermediate mathematical models to perform the link between physics-based analysis and circuit-oriented simulations, and only requires the evaluation of dc and ac small-signal (dc charge) sensitivities under general quasi-static conditions. To illustrate the technique, the authors discuss examples of sensitivity evaluation, statistical analysis, and doping profile optimization of an implanted MESFET to minimize intermodulation which makes use of LS parametric sensitivities under two-tone excitatio

Surface plasmon resonance imaging for affinity-based biosensors

SPR imaging (SPRi) is at the forefront of optical label-free and real-time detection. It offers the possibility of monitoring hundreds of biological interactions simultaneously and from the binding profiles, allows the estimation of the kinetic parameters of the interactions between the immobilised probes and the ligands in solution. We review the current state of development of SPRi technology and its application including commercially available SPRi instruments. Attention is also given to surface chemistries for biochip functionalisation and suitable approaches to improve sensitivity