LAURA: LocAlization and Ubiquitous monitoRing of pAtients for health care support

This works illustrates the LAURA system, which performs localization, tracking and monitoring of patients hosted at nursing institutes by exploiting a wireless sensor network based on the IEEE 801.15.4 (Zigbee) standard. We focus on the indoor personal localization module, which leverages a method based on received signal strength measurements, together with a particle filter to perform tracking of moving patients. We discuss the implementation and dimensioning of the localization and tracking system using commercial hardware, and we test the LAURA system in real environment, both with static and moving patients, achieving an average localization error lower than 2 m in 80% of the cases. The data sets containing the real measurements of received signal strengths collected during the experiments are made publicly available to enable reproducible research

Novelty in hypertension in children and adolescents: Focus on hypertension during the first year of life, use and interpretation of ambulatory blood pressure monitoring, role of physical activity in prevention and treatment, simple carbohydrates and uric acid as risk factors

The present article intends to provide an update of the article "Focus on prevention, diagnosis and treatment of hypertension in children and adolescents" published in 2013 (Spagnolo et al., Ital J Pediatr 39:20, 2013) in this journal. This revision is justified by the fact that during the last years there have been several new scientific contributions to the problem of hypertension in pediatric age and during adolescence. Nevertheless, for what regards some aspects of the previous article, the newly acquired information did not require substantial changes to what was already published, both from a cultural and from a clinical point of view. We felt, however, the necessity to rewrite and/or to extend other parts in the light of the most recent scientific publications. More specifically, we updated and extended the chapters on the diagnosis and management of hypertension in newborns and unweaned babies, on the use and interpretation of ambulatory blood pressure monitoring, and on the usefulness of and indications for physical activity. Furthermore, we added an entirely new section on the role that simple carbohydrates (fructose in particular) and uric acid may play in the pathogenesis of hypertension in pediatric age

Integrated platform for detecting pathogenic DNA via magnetic tunneling junction-based biosensors

In recent years, the development of portable platforms for performing fast and point-of-care analyses has drawn considerable attention for their wide variety of applications in life science. In this framework, tools combining magnetoresistive biosensors with magnetic markers have been widely studied in order to detect concentrations of specific molecules, demonstrating high sensitivity and ease of integration with conventional electronics. In this work, first, we develop a protocol for efficient hybridization of natural DNA; then, we show the detection of hybridization events involving natural DNA, namely genomic DNA extracted from the pathogenic bacterium Listeria monocytogenes, via a compact magnetic tunneling junction (MTJ)-based biosensing apparatus. The platform comprises dedicated portable electronic and microfluidic setups, enabling point-of-care biological assays. A sensitivity below the nM range is demonstrated. This work constitutes a step forward towards the development of portable lab-on-chip platforms, for the multiplexed detection of pathogenic health threats in food and food processing environment

Timing and protocols of clinical and endoscopic surveillance of Barrett's esophagus

Barrett\u2019s esophagus (BE) is a premalignant lesion in which normal squamous epi- thelium of the esophagus is replaced by metaplastic columnar epithelium of any histological subtype [1]. Several guidelines for diagnosing and managing BE have been published; however, they differ significantly among and within countries [1\u20133]. Only few large well-designed trials have been conducted so far [4\u20136]

The safety of beclomethasone dipropionate in the treatment of ulcerative colitis

Introduction: Beclomethasone dipropionate (BDP) is a second-generation corticosteroid that uses novel drug technologies to ensure colonic targeting and potentially reducing systemic corticosteroid concentrations. It is approved for treatment of patients with mild-to-moderate ulcerative colitis (UC) who do not respond to mesalazine. The gut-selective mechanism of action has the potential to improve the safety profile of BDP compared with other conventional corticosteroids. Areas covered: We reviewed the mechanism of action, efficacy, and safety of BDP in the treatment of UC. The positioning of BDP in management algorithms is also discussed. Expert opinion: The highly selective mechanism of action of BDP restricts the steroid-related side effects. BDP is efficacious in the treatment of active UC. Topical formulation is the first choice in distal UC, while oral formulation is used in patients with an extensive involvement of the colon. The rates of adverse events (AE), serious AEs, and steroid-related side-effects are similar to placebo and mesalamine and slightly inferior to traditional corticosteroids

Performance of Capsule Endoscopy and Cross-Sectional Techniques in detecting small bowel lesions in patients with Crohn's disease

Background: Crohn\u2019s disease (CD) can be classified according to endoscopic and cross-sectional imaging characteristics. Information regarding disease extent and phenotype may be provided by advanced endoscopic and imaging techniques. In this study, we compare the ability of capsule endoscopy (CE) and cross-sectional imaging techniques (CST) (MRE/Computer Tomography Enteroscopy [CTE]) in detecting small bowel (SB) lesions. Methods: We retrospectively analyzed 102 patients with a diagnosis of CD who underwent both CE and CST. Only patients with at least a 12-month follow-up after CE were included. Results: Sensitivity and specificity for the detection of SB lesions were, respectively, 100% and 83.3% for CE, 55.1% and 80% for CTE, and 60% and 82.3% for MRE. CE detected proximal CD lesions in 73% of patients, whereas MRE and CTE detected proximal lesions in 41% and 16% of patients, respectively (P < 0.001). Positive findings on CE led to management changes in all patients, in a median follow-up period of 58.7 months. During the follow-up period, 26.5% of patients underwent surgery. Multivariate analysis revealed that moderate-to-severe disease at CE was independently correlated with surgery (P = 0.03). Conclusions: CE has a superior sensitivity for detecting CD lesions in the proximal and medium SB compared with CST. In the terminal ileum, MRE and CTE displayed similar performance to CE

Implications of the Westernized Diet in the Onset and Progression of IBD

Inflammatory bowel diseases (IBD) are currently considered multifactorial pathologies in which various combined environmental factors act on a genetic background, giving rise to a chronic inflammation of the gastrointestinal tract. Among the various environmental factors, it now seems clear that the diet plays the major role in IBD onset and progression. Several clinical studies have attempted to understand the impact of diet in the development and progression of these diseases in order to establish useful guidelines for their management. However, the modest and sometimes contradictory results did not lead to the definition of shared dietary suggestions. On the other hand, food fads and recommendations based on anecdotal episodes are often followed by IBD patients to improve their diet. This review provides a critical overview of existing data on the role of diet as a risk factor for IBD. The methodology used was that of analyzing the results of clinical studies conducted on diet and IBD over the last 12 years through PubMed, as well as analyzing the most relevant studies on nutrients and their possible roles in IBD through the knowledge of the mechanisms by which they can modulate the microbiota or the intestinal physiology

Medical Treatment of Ulcerative Colitis: does traditional therapy still have a role?

Ulcerative colitis (UC) is a chronic inflammatory disease which involves the colonic mucosa continuously starting from the rectum and progressively involving the entire colon. Its etiology is still unknown, although numerous studies have clarified the inflammatory mechanisms involved in the pathogenesis, allowing the development of new targeted drugs. Correct medical treatment requires the evaluation of disease extension, activity and behavio

Synthesis and characterisation of a trithiocarbonate for the decoration of carbon nanostructures

A novel aldehyde-bearing trithiocarbonate has been synthesized and reacted with carbon nanostructures with different dimensionalities (nanotubes, fullerenes, graphite). The decoration of these carbon nanostructures with trithiocarbonate moieties should provide a powerful tool for the design of advanced carbon nanofillers