54 research outputs found
INFECĂĂO URINĂRIA NA PEDIATRIA: COMPREENDENDO SUAS REPERCUSSĂES: REVISĂO INTEGRATIVA
Introduction: Urinary tract infection in pediatrics is a common clinical condition affecting children and adolescents, being one of the main causes of consultations in emergency services and pediatric outpatient clinics.
Methodology: The search source included electronic databases recognized for their relevance and comprehensiveness in the biomedical field. The main databases selected were Google Scholar, Scielo, and PUBMED. These sources were chosen due to their ability to provide access to a wide range of high-quality studies, covering various disciplines and aspects related to the proposed topic.
Results: Diagnostic methods for urinary tract infection in pediatrics are essential to accurately identify the presence of infection and guide appropriate treatment. Proper urine sample collection is crucial to avoid contamination that could compromise test results.
Conclusion: In summary, urinary tract infections in pediatrics are a common but complex condition that requires a comprehensive approach for its management. Understanding the clinical, emotional, and social repercussions of these infections is fundamental to the development of effective diagnostic, treatment, and prevention strategiesIntrodução: Infecção urinĂĄria na pediatria Ă© uma condição clĂnica comum que afeta crianças e adolescentes, sendo uma das principais causas de consulta em serviços de emergĂȘncia e ambulatĂłrios pediĂĄtricos.
Metodologia: A fonte de busca incluiu bases de dados eletrĂŽnicas reconhecidas pela sua relevĂąncia e abrangĂȘncia na ĂĄrea biomĂ©dica. As principais bases de dados selecionadas foram Google AcadĂȘmico, Scielo e PUBMED. Estas fontes foram escolhidas devido Ă sua capacidade de fornecer acesso a uma vasta gama de estudos de alta qualidade, cobrindo diversas disciplinas e aspectos relacionados Ă temĂĄtica proposta.
Resultados: Os métodos diagnósticos para infecção urinåria na pediatria são essenciais para identificar com precisão a presença de infecção e para orientar o tratamento adequado. A coleta adequada de amostras de urina é crucial para evitar contaminaçÔes que possam comprometer os resultados dos exames.
ConclusĂŁo: Em resumo, as infecçÔes urinĂĄrias na pediatria sĂŁo uma condição comum, mas complexa, que requer uma abordagem abrangente para seu manejo. A compreensĂŁo das repercussĂ”es clĂnicas, emocionais e sociais dessas infecçÔes Ă© fundamental para o desenvolvimento de estratĂ©gias eficazes de diagnĂłstico, tratamento e prevenção
Anti-Inflammatory Activity of the Essential Oil Citral in Experimental Infection with Staphylococcus aureus
This study proposes to implement an alternative and effective strategy for local treatment of disease provoked by S. aureus. For the analysis of possible anti-inflammatory activity of essential oil, after establishing an air pouch model, 48 male mice of Balb/c were treated, infected, and euthanized at 4 and 8âh. Thus, the total and differential white blood cells were counted in the animalâs blood, and cytokines IL-1ÎČ, IL-6, and TNF-α were titrated using ELISA in the air pouch lavage. Moreover, TNF-α, IL-1ÎČ, and IL-6 gene expression was analyzed through an RT-qPCR array, and S. aureus was quantified using qPCR. Our results, p<0.05, showed that EOC reduced the quantity of microorganisms. The group of mice treated with essential oil citral showed a significant decrease in TNF-α levels in tests demonstrating anti-inflammatory activity. There is no data about the mutual influence of the air pouch model, essential oil citral, and S. aureus. Thus, considering the interaction of these variables and the anti-inflammatory activity of the essential oil citral, we demonstrated, by alternative local treatment, a new antimicrobial agent that is not an antibiotic
TendĂȘncias Atuais na EficĂĄcia e Mecanismos de Ação: Uma RevisĂŁo SistemĂĄtica sobre o Uso de AnĂĄlogos de GLP-1 no Tratamento da Obesidade
This work presents a systematic review on current trends in the effectiveness and mechanisms of action of GLP-1 analogs in the treatment of obesity. The introduction highlights the growing prevalence of obesity as a global public health challenge, positioning GLP-1 analogs as a promising approach. The methodology describes the formulation of the research question, study selection criteria, data extraction, and the analysis of study quality. The results emphasize the efficacy of these analogs in weight reduction, explore the neurobiological mechanisms involved, and demonstrate improvements in obesity-related comorbidities. The conclusion underscores the consistency of the reviewed evidence and the need for further research to optimize personalized therapeutic approaches.Este trabalho apresenta uma revisĂŁo sistemĂĄtica sobre as tendĂȘncias atuais na eficĂĄcia e nos mecanismos de ação dos anĂĄlogos de GLP-1 no tratamento da obesidade. A introdução destaca a crescente prevalĂȘncia da obesidade como um desafio global de saĂșde pĂșblica, situando os anĂĄlogos de GLP-1 como uma abordagem promissora. A metodologia descreve a formulação da pergunta de pesquisa, os critĂ©rios de seleção de estudos, a extração de dados e a anĂĄlise da qualidade dos estudos. Os resultados destacam a eficĂĄcia desses anĂĄlogos na redução de peso, exploram os mecanismos neurobiolĂłgicos envolvidos e evidenciam melhorias nas comorbidades associadas Ă obesidade. A conclusĂŁo ressalta a consistĂȘncia da evidĂȘncia revisada e a necessidade de pesquisas adicionais para otimizar abordagens terapĂȘuticas personalizadas
Sistema de controle interno da administração pĂșblica na UniĂŁo Europeia e no Brasil
- Divulgação dos SUMĂRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito Ă Lei de Direitos Autorais, nĂŁo disponibilizamos a obra na Ăntegra.- Localização na estante: 351.9(81+4) S622
Early and Late Pathogenic Events of Newborn Mice Encephalitis Experimentally Induced by Itacaiunas and CurionĂłpolis Bracorhabdoviruses Infection
In previous reports we proposed a new genus for Rhabdoviridae and described neurotropic preference and gross neuropathology in newborn albino Swiss mice after Curionopolis and Itacaiunas infections. In the present report a time-course study of experimental encephalitis induced by Itacaiunas and Curionopolis virus was conducted both in vivo and in vitro to investigate cellular targets and the sequence of neuroinvasion. We also investigate, after intranasal inoculation, clinical signs, histopathology and apoptosis in correlation with viral immunolabeling at different time points. Curionopolis and Itacaiunas viral antigens were first detected in the parenchyma of olfactory pathways at 2 and 3 days post-inoculation (dpi) and the first clinical signs were observed at 4 and 8 dpi, respectively. After Curionopolis infection, the mortality rate was 100% between 5 and 6 dpi, and 35% between 8 and 15 dpi after Itacaiunas infection. We identified CNS mice cell types both in vivo and in vitro and the temporal sequence of neuroanatomical olfactory areas infected by Itacaiunas and Curionopolis virus. Distinct virulences were reflected in the neuropathological changes including TUNEL immunolabeling and cytopathic effects, more intense and precocious after intracerebral or in vitro inoculations of Curionopolis than after Itacaiunas virus. In vitro studies revealed neuronal but not astrocyte or microglial cytopathic effects at 2 dpi, with monolayer destruction occurring at 5 and 7 dpi with Curionopolis and Itacaiunas virus, respectively. Ultrastructural changes included virus budding associated with interstitial and perivascular edema, endothelial hypertrophy, a reduced and/or collapsed small vessel luminal area, thickening of the capillary basement membrane, and presence of phagocytosed apoptotic bodies. Glial cells with viral budding similar to oligodendrocytes were infected with Itacaiunas virus but not with Curionopolis virus. Thus, Curionopolis and Itacaiunas viruses share many pathological and clinical features present in other rhabdoviruses but distinct virulence and glial targets in newborn albino Swiss mice brain
Acinic cell carcinoma of the oral and maxillofacial region : an international multicenter study
The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information. A total of 75 cases were included. Females (65.33%) with a mean age of 45.51 years were mostly affected. The lesions usually presented as an asymptomatic (64.28%) nodule (95.66%) in the parotid gland (70.68%). The association of two histopathological patterns was the most common finding (48.93%) and the tumors presented mainly conventional histopathological grades (86.11%). Surgical treatment was performed in the majority of the cases (59.19%). Local recurrence was observed in 20% of the informed cases, regional metastasis in 30.43%, and distant metastasis in 12.50%. The statistical analysis showed that the cases with a solid histopathological pattern (p=0.01), high-grade transformation (p=0.008), recurrence (p=0.007), and regional metastasis (p=0.03) were associated with poor survival. In conclusion, high histopathological transformation, presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region.The Brazilian National Council for Scientific and Technological Development (CNPq), the Coordination for the Improvement of Higher Education Personnel (CAPES) and the CNPq.https://www.scielo.br/j/boram2024Oral Pathology and Oral BiologySDG-03:Good heatlh and well-bein
Pervasive gaps in Amazonian ecological research
Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4
While the increasing availability of global databases on ecological communities has advanced our knowledge
of biodiversity sensitivity to environmental changes,5â7 vast areas of the tropics remain understudied.8â11 In
the American tropics, Amazonia stands out as the worldâs most diverse rainforest and the primary source of
Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13â15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazonâs biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus
crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced
environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian
Amazonia, while identifying the regionâs vulnerability to environmental change. 15%â18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by
2050. This means that unless we take immediate action, we will not be able to establish their current status,
much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio
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