Metabolic features of women with polycystic ovary syndrome in Latin America : a systematic review

Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder that commonly affects women of childbearing age and has been associated with metabolic and reproductive abnormalities. Only a few studies have investigated metabolic traits in women with PCOS in Latin America. Therefore, we conducted a systematic review to provide an overview of the available evidence on the metabolic profile of Latin American women with PCOS. Methods: We searched PubMed, Cochrane Central Register of Controlled Trials, and Embase databases for cross-sectional, case-control, or cohort studies focusing on populations of countries in South and Central America and Mexico, published until October 31, 2019. We selected studies that reported the diagnostic criteria for PCOS. In the absence of a control group, we included studies if they reported relevant metabolic data. Results: The initial search yielded 4878 records, of which 41 studies were included in the systematic review. Sample sizes ranged from 10 to 288 in PCOS groups and from 10 to 1500 in control groups. The prevalence of phenotypes A and B (classic PCOS) ranged from 65.8% to 87.5% as reported in studies from Argentina, Brazil, and Chile. Metabolic syndrome ranged from 33.3% to 44.0% for phenotype A, from 15.0% to 58.0% for phenotype B, from 11.9% to 36.0% for phenotype C, and from 14.2% to 66.0% for phenotype D. Women with PCOS had higher body mass index, waist circumference, blood pressure, glucose, and homeostasis model assessment index as well as a more adverse lipid profile than those without PCOS. Conclusions: Evidence from the present systematic review suggests that anthropometric and metabolic profiles are worse in women with PCOS who live in different Latin American countries than in women without PCOS living in the same region. Additional studies assessing metabolic comorbidities, such as diabetes, and distinct PCOS phenotypes in different Latin American countries are warranted and may produce invaluable information for primary and secondary prevention of PCOS in the region

Is there a relation between harmful oral habits and facial typology and dental occlusion?

OBJETIVO: verificar se há predominância de hábitos orais deletérios nos diferentes tipos faciais eaprofundar o estudo da relação entre os hábitos orais deletérios e a oclusão dentária. MÉTODO: foram analisados 307 prontuários de pacientes entre 2 e 59 anos de idade de ambos os sexos, encaminhados ao ambulatório do Instituto CEFAC. Foram anotados dos prontuários os hábitos orais deletérios, oclusão dentária, tipologia facial, sexo e idade. RESULTADOS: observou-se que os hábitos com maior prevalência são: chupeta (125 indivíduos), ranger dentes (115 indivíduos) e mamadeira (102 indivíduos). Dentre as comparações estudadas, as que apresentaram diferença estatisticamente significante foram: a presença do uso da chupeta no grupo de 9 a 12 anos, quando comparado ao de 6 a 9 anos (p=0,0269); presença do hábito de ranger dentes no grupo de 3 a 6 anos quando comparado ao grupo com mais de 20 anos (p=0,0393); presença do hábito de ranger dentes no grupo de oclusão dentária classe I quando comparado ao classe III (p=0,0128) e presença de oclusão dentária classe I no sexo feminino quando comparado ao masculino (p=0,0177). CONCLUSÃO: não há relação entre os hábitos orais deletérios e a tipologia facial. Entretanto, há relação entre o hábito oral deletério de ranger dentes com a oclusão dentária Classe I de Angle.PURPOSE: to check whether there is a predominance of deleterious oral habits in different facial typesand further study of the relationship between harmful oral habits and dental occlusion. METHOD: we analyzed 307 cases of patients between 2 and 59-year old of both genders, referred to the outpatient clinic of CEFAC Institute. Were we registered medical records of deleterious oral habits, dental occlusion, facial type, gender and age. RESULTS: we observed that the following habits are most prevalent: pacifier (125 subjects), gnashing teeth (115 subjects) and bottle (102 individuals). Among the comparisons, the ones who showed statistical significance was the presence of pacifier use in the group from 9 to 12 years, compared to 6 to 9 years (p=0.0269), presence of habit of gnashing teeth in the group from 3 to 6 years when compared to more than 20 years (p = 0.0393), presence of the habit of gnashing teeth in the group of dental occlusion class I compared to class III (p = 0.0128) and presence dental occlusion class I in females compared to males (p=0.0177). CONCLUSION: there is no relationship between harmful oral habits and facial typology. However, there is a relationship between the harmful oral habit of grinding the teeth with Angle class I dental occlusion

Transferable Fishing Concessions (TFC): A pilot study on the applicability in the Mediterranean Sea

Fisheries management systems based on Transferable Fishing Concessions (TFC) and similar rights-based systems have been developed during the last decades in some European countries. However, at present there is not a clear view on the possible effects caused by the application of this management systems in the Mediterranean Sea. The current study, involving nine Geographical Sub-Areas (GSAs) of the Mediterranean Sea, focuses on the appropriateness, transferability and modes of applicability of a TFC system in the Mediterranean area. Three different scenarios of quota allocation have been analyzed by taking into account biological, ecological, environmental, economic and social aspects: quota in terms of resource quantity, quota as a portion of the total fishing time, quota as a portion of the total fishing capacity. Results show that the transferability of a TFC-based system to the Mediterranean context appears to be low due to the characteristics of the Mediterranean fisheries (multispecificity of resources, fishing grounds shared among different countries, multigear, importance of small-scale fisheries) and to the general lack of sound and reliable individual historical data. The study also highlights rights-based systems such as Territorial Use Rights in Fisheries (TURF) might only be applied for the exploitation of sedentary resources, such as clams. A management system based on TFC could be theoretically reasonable for anchovy fishing, where a few species are caught, even if all countries and stakeholders should be involved in the decision making process

Metabolic profile of women with PCOS in Brazil : a systematic review and meta-analysis

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disease affecting women of reproductive age and associated with reproductive and metabolic dysfunction. Few studies are available regarding metabolic traits in Brazilian women with PCOS. The aim of this systematic review and meta-analysis was to summarize the available evidence regarding metabolic traits and comorbidities in Brazilian women with polycystic ovary syndrome (PCOS). Methods: We systematically searched PubMed, Cochrane Central Register of Controlled Trials, and Embase for cross-sectional, case–control, or cohort studies focusing on populations of different regions from Brazil, published until July 31, 2019. Studies were selected if they reported PCOS diagnostic criteria. Studies without a control group were included if they presented relevant metabolic data. Results: Of 4856 studies initially identified, 27 were included in the systematic review and 12 were included in the meta-analysis, for a total of 995 women with PCOS defined by Rotterdam criteria and 2275 controls from different regions of Brazil. Obesity, metabolic syndrome and IGT were prevalent, and standard mean differences for BMI (SMD 0.67, 95% CI, 0.29, 1.05), waist circumference (SMD 0.22, 95% CI 0.02, 0.41), systolic (SMD 0.66, 95% CI 0.30, 1.01) and diastolic blood pressure (SMD 0.55, 95% CI 0.24, 0.87), glucose (SMD 0.21, 95% CI 0.04, 0.38) and HOMA (SMD 0.78, 95% CI 0.52, 1.04) were significantly higher in Brazilian women with PCOS compared to controls. Lipid profile was more adverse in PCOS vs. non-PCOS women. Between-study heterogeneities were low/moderate for glucose and HOMA and moderate/high for the other variables. Conclusions: The data of this systematic review and meta-analysis indicate that Brazilian women with PCOS have a worse metabolic profile than women without PCOS with no important regional differences. The prevalence of metabolic changes is intermediate in Brazil vs. other countries

Performance of rice cultivars with the use of growth‑regulators in different cropping systems

O objetivo deste trabalho foi avaliar o efeito de reguladores de crescimento sobre o estabelecimento inicial e o desempenho agronômico de cultivares de arroz irrigado, em diferentes sistemas de cultivo. O experimento foi conduzido em ambiente controlado e em campo, com as cultivares Irga 424 e Irga 425, e os produtos ácido giberélico, tiametoxam e Haf Plus. Em campo, os tratamentos foram testados nos sistemas de cultivo convencional e pré‑germinado. Em ambiente controlado, as substâncias avaliadas promoveram a germinação de Irga 425, com incremento de 50% na germinação com o uso de tiametoxam, e de 39% com Haf Plus e ácido giberélico. Em campo, esse desempenho foi dependente do sistema de cultivo e da cultivar utilizada. O ácido giberélico causou estiolamento inicial, com reflexos na estatura da planta, na emissão de perfilhos e na deposição de biomassa vegetal. Tiametoxam e Haf Plus estimularam o perfilhamento das cultivares de arroz, nos dois sistemas de cultivo. Apesar de todos os produtos estimularem o número de panículas por metro quadrado, sua influência na produtividade de grãos não foi observada nos sistemas avaliados.The objective of this work was to evaluate the effect of growth‑regulating substances on initial establishment and agronomic performance of irrigated rice cultivars, in different cropping systems. The experiment was carried out in controlled environment and in field conditions, using the cultivars Irga 424 and Irga 425, and the products gibberellic acid, thiamethoxam and Haf Plus. At field, treatments were tested with conventional and pre‑germinated sowing systems. In the controlled environment, the evaluated substances promoted the germination of Irga 425, with an increase of 50% in germination with the use of thiamethoxam and of 39% with Haf Plus and gibberellic acid. In the field, this performance was dependent on the system and the cultivar used. Gibberellic acid caused initial blanching, which reflected in plant height, tiller emission, and deposition of vegetal biomass. Thiamethoxam and Haf Plus stimulated tillering of rice cultivars in both cultivation systems. Although all the products stimulated the number of panicles per square meter, there is no influence on grain yield in the evaluated systems

Prevalence and characteristics of polycystic ovary syndrome in brazilian women : protocol for a nation-wide case-control study

Introduction Brazil is a large country, with a population of mixed ethnic background and broad variation in dietary and physical activity traits across its five main regions. Because data on Brazilian women with polycystic ovary syndrome (PCOS) are still scarce, a nation-wide collaborative study was designed to determine the prevalence of metabolic and reproductive abnormalities and the presence of anxiety and depression in Brazilian women with PCOS. In addition, the study aims at describing how these characteristics are distributed across PCOS phenotypes and at detecting associations with regional demographic and lifestyle aspects, genetic variants, and epigenetic markers. Methods and analysis The Brazilian PCOS study is being conducted in the outpatient clinics of eight university hospitals within the public healthcare network (Unified Health System) across the country. Additional centres will be included following completion of the research ethics approval process. The sample includes women with PCOS according to Rotterdam criteria at inclusion in the study and a control group of healthy women matched by age, socioeconomic status and geographical region. Data will be collected in each centre and incorporated into a unified cloud database. Clinical, demographic, socioeconomic, psychological, metabolic, epigenetic and genotypic variables will be evaluated. The data resulting from this study will be useful to guide specific public strategies for primary and secondary prevention of metabolic and reproductive comorbidities in the PCOS population of Brazil