フクコウナイ ハシュ シュヨウ ノ ナイショウシャ リョウホウ ニ ムケタ アビジン ノ コウヒ ホウシャノウ ヒョウシキホウ ニ カンスル ケンキュウ

京都大学0048新制・課程博士博士(医学)甲第10697号医博第2681号新制||医||852(附属図書館)UT51-2004-G544京都大学大学院医学研究科内科系専攻(主査)教授 今村 正之, 教授 乾 賢一, 教授 平岡 眞寛学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDA

DEB TACE for Intermediate and advanced HCC - Initial Experience in a Brazilian Cancer Center

Submitted by Fábio Marques ([email protected]) on 2018-03-26T16:38:58Z No. of bitstreams: 1 ve_Jose_Luz_etal_INI_Lapclin_2017.pdf: 987236 bytes, checksum: 583e3d9ffcded716bc24daf2d5a1dd11 (MD5)Approved for entry into archive by Raquel Dinelis ([email protected]) on 2018-04-04T13:48:38Z (GMT) No. of bitstreams: 1 ve_Jose_Luz_etal_INI_Lapclin_2017.pdf: 987236 bytes, checksum: 583e3d9ffcded716bc24daf2d5a1dd11 (MD5)Made available in DSpace on 2018-04-04T13:48:38Z (GMT). No. of bitstreams: 1 ve_Jose_Luz_etal_INI_Lapclin_2017.pdf: 987236 bytes, checksum: 583e3d9ffcded716bc24daf2d5a1dd11 (MD5) Previous issue date: 2017Instituto Nacional de Câncer José Alencar Gomes da Silva, Departamento de Radiologia Intervencionista, Rio de Janeiro, RJ, BrasilFundação Oswaldo cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilInstituto Nacional de Câncer José Alencar Gomes da Silva, Departamento de Radiologia Intervencionista, Rio de Janeiro, RJ, BrasilInstituto Nacional de Câncer José Alencar Gomes da Silva, Departamento de Radiologia Intervencionista, Rio de Janeiro, RJ, BrasilHospital Federal de Bonsucesso. Departamento de Radiologia Intervencionista, Rio de Janeiro, RJ, BrasilHospital Federal de Bonsucesso. Departamento de Radiologia Intervencionista, Rio de Janeiro, RJ, BrasilHospital Federal de Ipanema. Departamento de Radiologia Intervencionista, Rio de Janeiro, RJ, BrasilInstituto Nacional de Câncer José Alencar Gomes da Silva, Departamento de Radiologia Intervencionista, Rio de Janeiro, RJ, BrasilUniversidade Federal de Minas Gerais. Escola de Medicina. Departamento de Anatomia e Radiologia. Minas Gerais, MG, Brasil.According to Barcelona Clinic Liver Cancer classification transarterial chemoembolization is indicated in patients with Hepatocellular Carcinoma in the intermediate stage. Drug-eluting microspheres can absorb and release the chemotherapeutic agent slowly for 14 days after its intra-arterial administration. This type of transarterial chemoembolization approach appears to provide at least equivalent effectiveness with less toxicity

Second harmonic generation imaging of the collagen architecture in prostate cancer tissue.

Optical microscopy has been one of the most important tools for visualizing biological samples since the seventeenth century. Recently, with the advances in femtosecond laser technology, all the nonlinear optical processes have now been included as optical microscopy methods, and second harmonic generation (SHG) microscopy has emerged as a powerful new optical imaging tool with applications in medicine and biology. Here we use SHG microscopy to obtain images of 76 prostate biopsies on histological slides. Multiple samples from the excised prostates of patients who underwent a radical prostatectomy were evaluated. The samples were collected from prostate positions as in needle biopsy procedures. The results show the collagen fiber architecture among malignant acini, and analysis of the fiber orientation in the images reveals that the collagen fibers become more aligned at higher malignancy grades. Furthermore, we find that the degree of fiber alignment correlates directly with the Gleason patterns

Raman spectroscopy with a 1064-nm wavelength laser as a potential molecular tool for prostate cancer diagnosis : a pilot study.

Raman spectroscopy is widely used to investigate the structure and property of the molecules from their vibrational transitions and may allow for the diagnosis of cancer in a fast, objective, and nondestructive manner. This experimental study aims to propose the use of the 1064-nm wavelength laser in a Raman spectroscopy and to evaluate its discrimination capability in prostate cancer diagnosis. Seventy-four spectra from patients who underwent radical prostatectomy were evaluated. The acquired signals were filtered, normalized, and corrected for possible oscillations in the laser intensity and fluorescence effects. Wilcoxon tests revealed significant differences between the benign and malign samples associated with the deformation vibration characteristic of nucleic acids, proteins, and lipids. A classifier based on support vector machines was able to predict the Gleason scores of the samples with 95% of accuracy, opening a perspective for the use of the 1064-nm excitatory wavelength in prostatic cancer diagnosis

A case report of male breast cancer in a very young patient: What is changing?

<p>Abstract</p> <p>Male breast cancer accounts for 1% of all breast cancer cases, and men tend to be diagnosed at an older age than women (mean age is about 67 years). Several risk factors have been identified, such as genetic and hormonal abnormalities.</p> <p>The present study reported the case of a 25-year-old man who was diagnosed with an advanced invasive ductal carcinoma; however, he did not have any important risk factors.</p> <p>Even though more data is emerging about this disease, more efforts to understand risk factors, treatment options and survival benefits are needed. In this case, we discussed the risk factors as well as the impaired fertility associated with breast cancer therapies.</p

Brazilian Flora 2020: Leveraging the power of a collaborative scientific network

International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora