4,497 research outputs found

    How watching Pinocchio movies changes our subjective experience of extrapersonal space

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    The way we experience the space around us is highly subjective. It has been shown that motion potentialities that are intrinsic to our body influence our space categorization. Furthermore, we have recently demonstrated that in the extrapersonal space, our categorization also depends on the movement potential of other agents. When we have to categorize the space as "Near" or "Far" between a reference and a target, the space categorized as "Near" is wider if the reference corresponds to a biological agent that has the potential to walk, instead of a biological and non-biological agent that cannot walk. But what exactly drives this "Near space extension"? In the present paper, we tested whether abstract beliefs about the biological nature of an agent determine how we categorize the space between the agent and an object. Participants were asked to first read a Pinocchio story and watch a correspondent video in which Pinocchio acts like a real human, in order to become more transported into the initial story. Then they had to categorize the location ("Near" or "Far") of a target object located at progressively increasing or decreasing distances from a non-biological agent (i.e., a wooden dummy) and from a biological agent (i.e., a human-like avatar). The results indicate that being transported into the Pinocchio story, induces an equal "Near" space threshold with both the avatar and the wooden dummy as reference frames

    Linear IgA bullous dermatosis

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    Linear IgA bullous dermatosis (LABD) is group of heterogeneous autoimmune subepidermal blistering diseases characterized by exclusively IgA autoantibodies targeting a component of the epidermal basement membrane zone. The laminina-lucida-type LABD, also known as chronic bullous dermatosis of childhood, is a rare disease, yet the most common autoimmune blistering disease among childeren with a peak incidence at 4-5 years of age. The major target antigens in laminina-lucida-type LABD are 120 kDa LAD-1 antigen, and its carboxyterminal proteolysed form 97 kDa LABD antigen 1 (LABD97). Both proteins are produced by cleavage of the extracellular domain of BP180, one of the main structural components of the hemidesmosome. The autoantigen targeted by IgA in the sublamina densa-type LABD, also known as IgA epidermolysis bullosa acquisita, is type VII collagen. In adults, LABD may also be drug-induced.</p

    IgA pemphigus

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    IgA pemphigus (IGAP) is a rare variant of pemphigus characterized by tissue-bound and circulating autoantibodies exclusively from the IgA class against desmosomal and non-desmosomal proteins of the epidermis. Based on the clinics, histology, direct immunofluorescence and autoantibody profile it is classified in two types: the subcorneal pustulosis dermatosis (SPD) type and the intraepidermal neutrophilic IgA dermatosis (IEN) type. The first line therapy is dapsone.</p

    Dermatological examination of bullous diseases

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    Physical examination in bullous diseases always comprises looking at skin and mucous membranes. Examine the skin not only for the presence of vesicles or bullae but also for other efflorescence's and typical distribution pattern. Nikolsky sign tests the resilience of the healthy-lookig skin. The mucous membranes of mouth, nose, eyes and genitals need to be examined systematically. Disease activity and extent of skin and mucous membranes can be assessed using disease activity outcome measures that are validated for pemphigus, bullous pemphigoid and mucous membrane pemphigoid.</p

    Dermatitis herpetiformis

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    Dermatitis herpetiformis (DH) is the specific skin manifestation of coeliac disease (CD) caused by the digestion of gluten in HLA-DQ2 or HLA-DQ8 individuals. DH is characterized by intensely pruritic polymorphic papulovesicular eruption on the extensor surfaces of the body. Both diseases are characterized by circulating IgA autoantibodies against tissue transglutaminase (tTG), which bind to the smooth muscle layer of the monkey esophagus causing the so-called EMA positivity. Additionally DH patient have another autoantibody population targeting the epidermal transglutaminase (eTG), the autoantigen of DH, which protein is highly homologous to tTG.</p

    Bullous dermatitis artefacta

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    Bullous dermatitis artefacta is a psychodermatologic disorder in patients who mimic skin disease by inflicting themselves blisters. The diagnosis is often apparent at first visit. The diagnosis should never be immediately revealed to the patient. Instead a serious, yet limited, workup is advised, while developing a trustful patient-doctor relation. The strategy is to give the patient the impression you know it was self-inflicted, but leaving an escape for clearance by trivial causes imagined by the patient such as avoiding drinking coffee (narrow escape). In refractory cases, when confrontation becomes unavoidable, dual approach by dermatologist and psychiatrist is necessary.</p

    Summarizing Industrial Log Data with Latent Dirichlet Allocation

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    Industrial systems and equipment produce large log files recording their activities and possible problems. This data is often used for troubleshooting and root cause analysis, but using the raw log data is poorly suited for direct human analysis. Existing approaches based on data mining and machine learning focus on troubleshooting and root cause analysis. However, if a good summary of industrial log files was available, the files could be used to monitor equipment and industrial processes and act more proactively on problems. This contribution shows how a topic modeling approach based on Latent Dirichlet Allocation (LDA) helps to understand, organize and summarize industrial log files. The approach was tested on a real-world industrial dataset and evaluated quantitatively by direct annotation

    Surface modification of aluminum by runaway electron preionized diffuse discharges in different gases at atmospheric pressure

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    The paper presents the results of an examination of aluminum samples exposed to runaway electron preionized diffuse discharges in air, nitrogen, and argon at atmospheric pressure. The changes in the chemical composition, structure, and hardness of the aluminum surface layers caused by the action of the discharge were investigated. It has been found that the oxygen and carbon concentrations in the surface layers depend on the number of discharge pulses and on the chemical composition of the working gas. The goal of the study was to find possible uses of runaway electron preionized diffuse discharges in research and industry
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