1,321 research outputs found
Compensation effects in GaN:Mg probed by Raman spectroscopy and photoluminescence measurements
This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in J. Appl. Phys. 113, 103504 (2013) and may be found at https://doi.org/10.1063/1.4794094.Compensation effects in metal organic chemical vapour deposition grown GaN doped with magnesium are investigated with Raman spectroscopy and photoluminescence measurements. Examining the strain sensitive E2(high) mode, an increasing compressive strain is revealed for samples with Mg-concentrations lower than 7 × 1018 cm−3. For higher Mg-concentrations, this strain is monotonically reduced. This relaxation is accompanied by a sudden decrease in crystal quality. Luminescence measurements reveal a well defined near band edge luminescence with free, donor bound, and acceptor bound excitons as well as a characteristic donor acceptor pair (DAP) luminescence. Following recent results, three acceptor bound excitons and donor acceptor pairs are identified. Along with the change of the strain, a strong modification in the luminescence of the dominating acceptor bound exciton and DAP luminescence is observed. The results from Raman spectroscopy and luminescence measurements are interpreted as fingerprints of compensation effects in GaN:Mg leading to the conclusion that compensation due to defect incorporation triggered by Mg-doping already affects the crystal properties at doping levels of around 7 × 1018 cm−3. Thereby, the generation of nitrogen vacancies is introduced as the driving force for the change of the strain state and the near band edge luminescence.DFG, 43659573, SFB 787: Halbleiter - Nanophotonik: Materialien, Modelle, Bauelement
Artificial photosynthesis: semiconductor photocatalytic fixation of CO_2 to afford higher organic compounds
Carbon dioxide is an appealing renewable feedstock for industrial chemical processes. This does not mean, however, that all chemical processes using CO_2 are environmentally-friendly. Perspectives on the sustainability of CO_2 utilization and artificial photosynthesis are provided. The discussions focus on the photocatalytic production of C_x (x ≥ 2) compounds, where all the carbon in the products is derived from CO_2. This area of research, while promising, has received far less attention than analogous systems leading to C_1 products
Dynamics of new strain emergence on a temporal network
Multi-strain competition on networks is observed in many contexts, including
infectious disease ecology, information dissemination or behavioral adaptation
to epidemics. Despite a substantial body of research has been developed
considering static, time-aggregated networks, it remains a challenge to
understand the transmission of concurrent strains when links of the network are
created and destroyed over time. Here we analyze how network dynamics shapes
the outcome of the competition between an initially endemic strain and an
emerging one, when both strains follow a susceptible-infected-susceptible
dynamics, and spread at time scales comparable with the network evolution one.
Using time-resolved data of close-proximity interactions between patients
admitted to a hospital and medical health care workers, we analyze the impact
of temporal patterns and initial conditions on the dominance diagram and
coexistence time. We find that strong variations in activity volume cause the
probability that the emerging strain replaces the endemic one to be highly
sensitive to the time of emergence. The temporal structure of the network
shapes the dominance diagram, with significant variations in the replacement
probability (for a given set of epidemiological parameters) observed from the
empirical network and a randomized version of it. Our work contributes towards
the description of the complex interplay between competing pathogens on
temporal networks.Comment: 9 pages, 4 figure
Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats.
The heptapeptide angiotensin-(1-7) (Ang-(1-7)) is protective in the cardiovascular system through its induction of vasodilator production and angiogenesis. Despite acting antagonistically to the effects of elevated, pathophysiological levels of angiotensin II (AngII), recent evidence has identified convergent and beneficial effects of low levels of both Ang-(1-7) and AngII. Previous work identified the AngII receptor type I (AT1R) as a component of the protein complex formed when Ang-(1-7) binds its receptor, Mas1. Importantly, pharmacological blockade of AT1R did not alter the effects of Ang-(1-7). Here, we use a novel mutation of AT1RA in the Dahl salt-sensitive (SS) rat to test the hypothesis that interaction between Mas1 and AT1R contributes to proangiogenic Ang-(1-7) signaling. In a model of hind limb angiogenesis induced by electrical stimulation, we find that the restoration of skeletal muscle angiogenesis in SS rats by Ang-(1-7) infusion is impaired in AT1RA knockout rats. Enhancement of endothelial cell (EC) tube formation capacity by Ang-(1-7) is similarly blunted in AT1RA mutant ECs. Transcriptional changes elicited by Ang-(1-7) in SS rat ECs are altered in AT1RA mutant ECs, and tandem mass spectrometry-based proteomics demonstrate that the protein complex formed upon binding of Ang-(1-7) to Mas1 is altered in AT1RA mutant ECs. Together, these data support the hypothesis that interaction between AT1R and Mas1 contributes to proangiogenic Ang-(1-7) signaling
Grid Code-Dependent Frequency Control Optimization in Multi-Terminal DC Networks
The increasing deployment of wind power is reducing inertia in power systems.
High-voltage direct current (HVDC) technology can help to improve the stability of AC areas in
which a frequency response is required. Moreover, multi-terminal DC (MTDC) networks can be
optimized to distribute active power to several AC areas by droop control setting schemes that adjust
converter control parameters. To this end, in this paper, particle swarm optimization (PSO) is used
to improve the primary frequency response in AC areas considering several grid limitations and
constraints. The frequency control uses an optimization process that minimizes the frequency nadir
and the settling time in the primary frequency response. Secondly, another layer is proposed for the
redistribution of active power among several AC areas, if required, without reserving wind power
capacity. This method takes advantage of the MTDC topology and considers the grid code limitations
at the same time. Two scenarios are defined to provide grid code-compliant frequency control.Australian Education International, Australian Government TEC2016-80242-PMinisterio de Economía y Competitividad DPI2016-75294-C2-2-
Feasibility of the porous zone approach to modelling vegetation in CFD
Vegetation within stormwater ponds varies seasonly and its presence affects the flow field, which in turn affects the pond’s Residence Time Distribution and its effectiveness at pollutant removal. Vegetated flows are complex and, as a result, few suitable tools exist for evaluating realistic stormwater pond designs. Recent research has suggested using a porous zone to represent vegetation within a CFD model, and this paper investigates the feasibility of this approach using ANSYS Fluent. One of the main benefits of using a porous zone is the ability to derive the relevant parameters from the known physical characteristics of stem diameter and porosity using the Ergun equation. A sensitivity analysis on the viscous resistance factor 1/α1/α and the inertial resistance factor C2C2 has been undertaken by comparing model results to data collected from an experimental vegetated channel. Best fit values of C2C2 were obtained for a range of flow conditions including emergent and submerged vegetation. Results show the CFD model to be insensitive to 1/α1/α but very sensitive to values of C2C2. For submerged vegetation, values of C2C2 derived from the Ergun equation are under-predictions of best-fit C2C2 values as only the turbulence due to the shear layer is represented. The porous zone approach does not take into account turbulence generated from stem wakes such that no meaningful predictions for emergent vegetation were obtained. C2C2 values calculated using a force balance show better agreement with best-fit C2C2 values than those derived from the Ergun equation. Manually fixing values of kk and εε within the porous zone of the model shows initial promise as a means of taking stem wakes into account
Reconciliation of essential process parameters for an enhanced predictability of Arctic stratospheric ozone loss and its climate interactions
Significant reductions in stratospheric ozone occur inside the polar vortices each spring when chlorine radicals produced by heterogeneous reactions on cold particle surfaces in winter destroy ozone mainly in two catalytic cycles, the ClO dimer cycle and the ClO/BrO cycle. Chlorofluorocarbons (CFCs), which are responsible for most of the chlorine currently present in the stratosphere, have been banned by the Montreal Protocol and its amendments, and the ozone layer is predicted to recover to 1980 levels within the next few decades. During the same period, however, climate change is expected to alter the temperature, circulation patterns and chemical composition in the stratosphere, and possible geo-engineering ventures to mitigate climate change may lead to additional changes. To realistically predict the response of the ozone layer to such influences requires the correct representation of all relevant processes. The European project RECONCILE has comprehensively addressed remaining questions in the context of polar ozone depletion, with the objective to quantify the rates of some of the most relevant, yet still uncertain physical and chemical processes. To this end RECONCILE used a broad approach of laboratory experiments, two field missions in the Arctic winter 2009/10 employing the high altitude research aircraft M55-Geophysica and an extensive match ozone sonde campaign, as well as microphysical and chemical transport modelling and data assimilation. Some of the main outcomes of RECONCILE are as follows: (1) vortex meteorology: the 2009/10 Arctic winter was unusually cold at stratospheric levels during the six-week period from mid-December 2009 until the end of January 2010, with reduced transport and mixing across the polar vortex edge; polar vortex stability and how it is influenced by dynamic processes in the troposphere has led to unprecedented, synoptic-scale stratospheric regions with temperatures below the frost point; in these regions stratospheric ice clouds have been observed, extending over >106km2 during more than 3 weeks. (2) Particle microphysics: heterogeneous nucleation of nitric acid trihydrate (NAT) particles in the absence of ice has been unambiguously demonstrated; conversely, the synoptic scale ice clouds also appear to nucleate heterogeneously; a variety of possible heterogeneous nuclei has been characterised by chemical analysis of the non-volatile fraction of the background aerosol; substantial formation of solid particles and denitrification via their sedimentation has been observed and model parameterizations have been improved. (3) Chemistry: strong evidence has been found for significant chlorine activation not only on polar stratospheric clouds (PSCs) but also on cold binary aerosol; laboratory experiments and field data on the ClOOCl photolysis rate and other kinetic parameters have been shown to be consistent with an adequate degree of certainty; no evidence has been found that would support the existence of yet unknown chemical mechanisms making a significant contribution to polar ozone loss. (4) Global modelling: results from process studies have been implemented in a prognostic chemistry climate model (CCM); simulations with improved parameterisations of processes relevant for polar ozone depletion are evaluated against satellite data and other long term records using data assimilation and detrended fluctuation analysis. Finally, measurements and process studies within RECONCILE were also applied to the winter 2010/11, when special meteorological conditions led to the highest chemical ozone loss ever observed in the Arctic. In addition to quantifying the 2010/11 ozone loss and to understand its causes including possible connections to climate change, its impacts were addressed, such as changes in surface ultraviolet (UV) radiation in the densely populated northern mid-latitudes
Reconciliation of essential process parameters for an enhanced predictability of Arctic stratospheric ozone loss and its climate interactions : (RECONCILE) ; activities and results
The international research project RECONCILE has addressed central questions regarding polar ozone depletion, with the objective to quantify some of the most relevant yet still uncertain physical and chemical processes and thereby improve prognostic modelling capabilities to realistically predict the response of the ozone layer to climate change. This overview paper outlines the scope and the general approach of RECONCILE, and it provides a summary of observations and modelling in 2010 and 2011 that have generated an in many respects unprecedented dataset to study processes in the Arctic winter stratosphere. Principally, it summarises important outcomes of RECONCILE including (i) better constraints and enhanced consistency on the set of parameters governing catalytic ozone destruction cycles, (ii) a better understanding of the role of cold binary aerosols in heterogeneous chlorine activation, (iii) an improved scheme of polar stratospheric cloud (PSC) processes that includes heterogeneous nucleation of nitric acid trihydrate (NAT) and ice on non-volatile background aerosol leading to better model parameterisations with respect to denitrification, and (iv) long transient simulations with a chemistry-climate model (CCM) updated based on the results of RECONCILE that better reproduce past ozone trends in Antarctica and are deemed to produce more reliable predictions of future ozone trends. The process studies and the global simulations conducted in RECONCILE show that in the Arctic, ozone depletion uncertainties in the chemical and microphysical processes are now clearly smaller than the sensitivity to dynamic variability
Comment on Spracklandus Hoser, 2009 (Reptilia, Serpentes, ELAPIDAE): request for confirmation of the availability of the generic name and for the nomenclatural validation of the journal in which it was published (Case 3601; see BZN 70: 234–237; 71: 30–38, 133–135, 181–182, 252–253)
Phase 1/2a trial of intravenous BAL101553, a novel controller of the spindle assembly checkpoint, in advanced solid tumours
Background:
BAL101553 (lisavanbulin), the lysine prodrug of BAL27862 (avanbulin), exhibits broad anti-proliferative activity in human cancer models refractory to clinically relevant microtubule-targeting agents.
Methods:
This two-part, open-label, phase 1/2a study aimed to determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of 2-h infusion of BAL101553 in adults with advanced or recurrent solid tumours. The MTD was determined using a modified accelerated titration design in phase I. Patients received BAL101553 at the MTD and at lower doses in the phase 2a expansion to characterise safety and efficacy and to determine the recommended phase 2 dose (RP2D).
Results:
Seventy-three patients received BAL101553 at doses of 15–80 mg/m2 (phase 1, n = 24; phase 2a, n = 49). The MTD was 60 mg/m2; DLTs observed at doses ≥60 mg/m2 were reversible Grade 2–3 gait disturbance with Grade 2 peripheral sensory neuropathy. In phase 2a, asymptomatic myocardial injury was observed at doses ≥45 mg/m2. The RP2D for 2-h intravenous infusion was 30 mg/m2. The overall disease control rate was 26.3% in the efficacy population.
Conclusions:
The RP2D for 2-h infusion of BAL101553 was well tolerated. Dose-limiting neurological and myocardial side effects were consistent with the agent’s vascular-disrupting properties.
Clinical trial registration:
EudraCT: 2010-024237-23
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