Associations between depressive symptoms and disease progression in older patients with chronic kidney disease: results of the EQUAL study

Background Depressive symptoms are associated with adverse clinical outcomes in patients with end-stage kidney disease; however, few small studies have examined this association in patients with earlier phases of chronic kidney disease (CKD). We studied associations between baseline depressive symptoms and clinical outcomes in older patients with advanced CKD and examined whether these associations differed depending on sex. Methods CKD patients (>= 65 years; estimated glomerular filtration rate <= 20 mL/min/1.73 m(2)) were included from a European multicentre prospective cohort between 2012 and 2019. Depressive symptoms were measured by the five-item Mental Health Inventory (cut-off <= 70; 0-100 scale). Cox proportional hazard analysis was used to study associations between depressive symptoms and time to dialysis initiation, all-cause mortality and these outcomes combined. A joint model was used to study the association between depressive symptoms and kidney function over time. Analyses were adjusted for potential baseline confounders. Results Overall kidney function decline in 1326 patients was -0.12 mL/min/1.73 m(2)/month. A total of 515 patients showed depressive symptoms. No significant association was found between depressive symptoms and kidney function over time (P = 0.08). Unlike women, men with depressive symptoms had an increased mortality rate compared with those without symptoms [adjusted hazard ratio 1.41 (95% confidence interval 1.03-1.93)]. Depressive symptoms were not significantly associated with a higher hazard of dialysis initiation, or with the combined outcome (i.e. dialysis initiation and all-cause mortality). Conclusions There was no significant association between depressive symptoms at baseline and decline in kidney function over time in older patients with advanced CKD. Depressive symptoms at baseline were associated with a higher mortality rate in men

Wall current monitor using PXI and LabVIEW at CERN

The new data acquisition system for the PS ring wall current monitors installed in the PS is able to perform high frequency measurements of a beam bunch up to a frequency of 2.7 GHz. This is an important improvement, since the oscillating signal within the bandwidth 500-700 MHz, is related to losses of a beam bunch. The losses could be eventually reduced by measuring the frequency and classifying the cause of the oscillations. The PXI-5661 is used to carry out spectral analysis of this signal. The acquisition is performed on a PXI running LabVIEW Real-Time and synchronized using a trigger from the accelerator timing system

Wall current monitor using PXI and LabVIEW at CERN

The new data acquisition system for the PS ring wall current monitors installed in the PS is able to perform high frequency measurements of a beam bunch up to a frequency of 2.7 GHz. This is an important improvement, since the oscillating signal within the bandwidth 500-700 MHz, is related to losses of a beam bunch. The losses could be eventually reduced by measuring the frequency and classifying the cause of the oscillations. The PXI-5661 is used to carry out spectral analysis of this signal. The acquisition is performed on a PXI running LabVIEW Real-Time and synchronized using a trigger from the accelerator timing system

SEE Testing in the 24-GeV Proton Beam at the CHARM Facility

A 24-GeV proton beam is available at the Cern High energy AcceleRator Mixed field facility which can be used to test components and boards for single-event effects (SEEs) at a worst case energy for both accelerator and interplanetary space applications. The main beam characteristics are described, and SEE results for three different components are presented in combination with Monte Carlo results, focusing on the significant energy dependence, and risk of underestimating the operational error rate for hard spectral environments when considering SEE cross sections measured at proton cyclotron facilities

From ERATO Basic Research to the Blue Edge Rotor Blade

In 2015, Airbus Helicopters unveiled the secrecy around its Dauphin successor and presented the all new H160 heli-copter. A special feature immediately attracting attention is its unusual and revolutionary fore-aft swept main rotor blade. This design, aiming at significantly reducing the blade-vortex interaction noise signature and also reducing fast forward flight power requirements, finds its origins far back in the 1990s, when DLR and ONERA formed a joint team to acoustically optimize a rectangular reference rotor blade. Based on state-of-the-art comprehensive rotor codes and a 50-50 work share, the ERATO rotor blade design was developed, patented worldwide and tested on a rotor test rig and in the wind tunnel. Airbus Helicopters (then: Eurocopter) took up that design, optimized hover and forward flight high lift performance and prepared it for serial production, until it finally made it as the Blue EdgeTM rotor blade on the Airbus Helicopters H160 helicopter. The paper covers the history and technical achievements, wind tunnel test results and flight tests

From ERATO Basic Research to the Blue Edge Rotor Blade: an Example of Virtual Engineering?

In 2015, Airbus Helicopters unveiled the secrecy around its Dauphin successor and presented the all new H160 heli-copter. A special feature immediately attracting attention is its unusual and revolutionary fore-aft swept main rotor blade. This design, aiming at significantly reducing the blade-vortex interaction noise signature and also reducing fast forward flight power requirements, finds its origins far back in the 1990s, when DLR and ONERA formed a joint team to acoustically optimize a rectangular reference rotor blade. Based on state-of-the-art comprehensive rotor codes and a 50-50 work share, the ERATO rotor blade design was developed, patented worldwide and tested on a rotor test rig and in the wind tunnel. Airbus Helicopters (then: Eurocopter) took up that design, optimized hover and forward flight high lift performance and prepared it for serial production, until it finally made it as the Blue EdgeTM rotor blade on the Airbus Helicopters H160 helicopter. The paper covers the history and technical achievements, wind tunnel test results and flight tests

From Aeroacoustics Basic Research to a Modern Low Noise Rotor Blade

In 2015, Airbus Helicopters unveiled the secrecy around its Dauphin successor and presented the all new H160 helicopter. A special feature that immediately attracted attention was its unusual and revolutionary fore-aft swept main rotor blade. This design, which aims to significantly reduce the blade-vortex interaction noise signature and reduce high-speed forward flight power requirements, was first investigated in the 1990s. At this time, DLR and ONERA formed a joint team to acoustically optimize a rectangular reference rotor blade. Based on state-of-the-art comprehensive rotor codes and a 50/50 work share, the ERATO rotor blade design was developed, patented worldwide and tested on both a rotor test rig and in the wind tunnel. Airbus Helicopters (then: Eurocopter) adopted the design, optimized hover and forward flight high lift performance and prepared it for serial production, as the Blue EdgeTM rotor blade on the Airbus Helicopters H160 helicopter

From ERATO Basic Research to the Blue EdgeTM Rotor Blade: an Example of Virtual Engineering ?

International audienceIn 2015, Airbus Helicopters unveiled the secrecy around its Dauphin successor and presented the all new H160 helicopter. A special feature immediately attracting attention is its unusual and revolutionary fore-aft swept main rotor blade. This design, aiming at reducing the blade-vortex interaction noise signature and also reducing fast forward flight power requirements, finds its origins far back in the 90s, when DLR and ONERA formed a joint team to acoustically optimize a rectangular reference rotor blade. Based on state-of-the-art comprehensive rotor codes and a 50-50 work share, the ERATO rotor blade design was developed, patented worldwide and tested on a rotor test rig and in the wind tunnel. Airbus Helicopters took up that design, optimized hover and forward flight high lift performance and prepared it for serial production, until it finally made it as the Blue Edge TM rotor blade on the H160 helicopter. The paper covers the history and technical achievements, wind tunnel test results and flight tests

Design and Development of an Innovative Low Noise Rotor

In 2015, Airbus Helicopters unveiled the secrecy around its Dauphin successor and presented the all new H160 helicopter. A special feature immediately attracting attention is its unusual and revolutionary fore-aft swept main rotor blade. This design, aiming at significantly reducing the so-called blade-vortex interaction noise signature and also reducing fast forward flight power requirements, finds its origins far back in the 1990s. At that time DLR and ONERA formed a joint team to acoustically optimize a rectangular reference rotor blade. Based on state-of-the-art comprehensive rotor codes and a 50-50 work share, the ERATO rotor blade design was developed, patented worldwide and tested on a rotor test rig and in both wind tunnels, DNW-LLF in the Netherlands and S1 in France. Airbus Helicopters (then: Eurocopter) took up that design, optimized hover and forward flight high lift performance and prepared it for serial production, until it finally made it as the Blue EdgeTM rotor blade on the Airbus Helicopters H160 helicopter. The presentation covers the motivation for noise reduction, the history of the ERATO/Blue EdgeTM rotor blades and technical achievements, wind tunnel test results and flight test