Caccioppoli's inequalities on constant mean curvature hypersurfaces in Riemannian manifolds

This is a revised version (minor changes and a deeper insight in the positive curvature case). We prove some Caccioppoli's inequalities for the traceless part of the second fundamental form of a complete, noncompact, finite index, constant mean curvature hypersurface of a Riemannian manifold, satisfying some curvature conditions. This allows us to unify and clarify many results scattered in the literature and to obtain some new results. For example, we prove that there is no stable, complete, noncompact hypersurface in ${\mathbb R}^{n+1},$ $n\leq 5,$ with constant mean curvature $H\not=0,$ provided that, for suitable $p,$ the $L^p$-norm of the traceless part of second fundamental form satisfies some growth condition.Comment: 31 page

Familial multiple cavernous malformation syndrome : MR features in this uncommon but silent threat

Cerebral cavernous malformations (CCM) are vascular malformations in the brain and spinal cord. The familial form of cerebral cavernous malformation (FCCM) is uncommon. This autosomal dominant pathology mostly presents with seizures and focal neurological symptoms. Many persons affected by FCCM remain asymptomatic. However, acute hemorrhages may appear over time. MRI demonstrates multiple focal regions of susceptibility induced signal loss, well seen on gradient-echo sequences (GRE) or even better on susceptibility-weighted imaging (SWI). The presence of a single CCM – especially in young persons – without history of FCCM does not exclude this diagnosis. Some clinicians also advise an MRI of the spinal cord at the time of diagnosis to serve as a baseline and a control MRI of the brain every one to two years. MRI is certainly indicated in individuals with obvious new neurologic symptoms. Symptomatic siblings should also undergo an MRI of the brain to determine presence, size, and location of the lesions. Even in asymptomatic siblings, a screening MRI may be considered, as there may be an increased risk of hemorrhage, spontaneous or due to the use of certain medications; the knowledge of the presence and the type of these lesions are important. Surgical removal of a CCM may be justified to prevent a life-threatening hemorrhage. Control MRI may reveal the postoperative outcome

Options on Hedge Funds under the High Water Mark Rule

The rapidly growing hedge fund industry has provided individual and institutional investors with new investment vehicles and styles of management. It has also brought forward a new form of performance contract: hedge fund managers receive incentive fees which are typically a fraction of the fund net asset value (NAV) above its starting level - a rule known as high water mark. Options on hedge funds are becoming increasingly popular, in particular because they allow investors with limited capital to get exposure to this new asset class. The goal of the paper is to propose a valuation of plain-vanilla options on hedge funds which accounts for the high water market rule. Mathematically, this valuation leads to an interesting use of local times of Brownian motion. Option prices are numerically computed by inversion of their Laplace transforms

Fluctuation effects in metapopulation models: percolation and pandemic threshold

Metapopulation models provide the theoretical framework for describing disease spread between different populations connected by a network. In particular, these models are at the basis of most simulations of pandemic spread. They are usually studied at the mean-field level by neglecting fluctuations. Here we include fluctuations in the models by adopting fully stochastic descriptions of the corresponding processes. This level of description allows to address analytically, in the SIS and SIR cases, problems such as the existence and the calculation of an effective threshold for the spread of a disease at a global level. We show that the possibility of the spread at the global level is described in terms of (bond) percolation on the network. This mapping enables us to give an estimate (lower bound) for the pandemic threshold in the SIR case for all values of the model parameters and for all possible networks.Comment: 14 pages, 13 figures, final versio

New Bounds on Isotropic Lorentz Violation

Violations of Lorentz invariance that appear via operators of dimension four or less are completely parameterized in the Standard Model Extension (SME). In the pure photonic sector of the SME, there are nineteen dimensionless, Lorentz-violating parameters. Eighteen of these have experimental upper bounds ranging between 10^{-11} and 10^{-32}; the remaining parameter, k_tr, is isotropic and has a much weaker bound of order 10^{-4}. In this Brief Report, we point out that k_tr gives a significant contribution to the anomalous magnetic moment of the electron and find a new upper bound of order 10^{-8}. With reasonable assumptions, we further show that this bound may be improved to 10^{-14} by considering the renormalization of other Lorentz-violating parameters that are more tightly constrained. Using similar renormalization arguments, we also estimate bounds on Lorentz violating parameters in the pure gluonic sector of QCD.Comment: 10 pages, 1 figure. v2: reference adde

CopulaDTA: An R Package for Copula Based Bivariate Beta-Binomial Models for Diagnostic Test Accuracy Studies in a Bayesian Framework

The current statistical procedures implemented in statistical software packages for pooling of diagnostic test accuracy data include hSROC regression and the bivariate random-effects meta-analysis model (BRMA). However, these models do not report the overall mean but rather the mean for a central study with random-effect equal to zero and have difficulties estimating the correlation between sensitivity and specificity when the number of studies in the meta-analysis is small and/or when the between-study variance is relatively large. This tutorial on advanced statistical methods for meta-analysis of diagnostic accuracy studies discusses and demonstrates Bayesian modeling using CopulaDTA package in R to fit different models to obtain the meta-analytic parameter estimates. The focus is on the joint modelling of sensitivity and specificity using copula based bivariate beta distribution. Essentially, we extend the work of Nikoloulopoulos by: i) presenting the Bayesian approach which offers flexibility and ability to perform complex statistical modelling even with small data sets and ii) including covariate information, and iii) providing an easy to use code. The statistical methods are illustrated by re-analysing data of two published meta-analyses. Modelling sensitivity and specificity using the bivariate beta distribution provides marginal as well as study-specific parameter estimates as opposed to using bivariate normal distribution (e.g., in BRMA) which only yields study-specific parameter estimates. Moreover, copula based models offer greater flexibility in modelling different correlation structures in contrast to the normal distribution which allows for only one correlation structure.Comment: 26 pages, 5 figure

A new look at Lorentz-Covariant Loop Quantum Gravity

In this work, we study the classical and quantum properties of the unique commutative Lorentz-covariant connection for loop quantum gravity. This connection has been found after solving the second-class constraints inherited from the canonical analysis of the Holst action without the time-gauge. We show that it has the property of lying in the conjugacy class of a pure \su(2) connection, a result which enables one to construct the kinematical Hilbert space of the Lorentz-covariant theory in terms of the usual \SU(2) spin-network states. Furthermore, we show that there is a unique Lorentz-covariant electric field, up to trivial and natural equivalence relations. The Lorentz-covariant electric field transforms under the adjoint action of the Lorentz group, and the associated Casimir operators are shown to be proportional to the area density. This gives a very interesting algebraic interpretation of the area. Finally, we show that the action of the surface operator on the Lorentz-covariant holonomies reproduces exactly the usual discrete \SU(2) spectrum of time-gauge loop quantum gravity. In other words, the use of the time-gauge does not introduce anomalies in the quantum theory.Comment: 28 pages. Revised version taking into account referee's comment

Frequency-locked chaotic opto-RF oscillator

A driven opto-RF oscillator, consisting of a dual-frequency laser (DFL) submitted to frequency-shifted feedback, is studied experimentally and numerically in a chaotic regime. Precise control of the reinjection strength and detuning permits to isolate a parameter region of bounded-phase chaos, where the opto-RF oscillator is frequency-locked to the master oscillator, in spite of chaotic phase and intensity oscillations. Robust experimental evidence of this synchronization regime is found and phase noise spectra allows to compare phase-locking and bounded-phase chaos regimes. In particular, it is found that the long-term phase stability of the master oscillator is well transferred to the opto-RF oscillator even in the chaotic regime