Efecto de los antimaláricos sobre los diferentes dominios del índice de daño SLICC en pacientes de la cohorte GLADEL

Objetivos: estimar el efecto de los antimaláricos (AM) sobre los diferentes dominios del índice de daño SLICC (SDI). Métodos: se estudiaron pacientes con diagnóstico clínico reciente (≤2 años) de lupus eritematoso sistémico (LES) de la cohorte GLADEL

Estandarización de la versión Peruana del Índice de Incapacidad Funcional del Cuestionario de Evaluación de Salud (Health Assesment Questionnaire - HAQ)

Objective: Standarization of a Peruvian version for the functional incapacity Index of the Health Assessment Questionaire (HAQ). Material and Methods: Forty one patients with Rheumatoid Arthritis, from 3 different Hospitals of Lima, were evaluated. All of them underwent HAQ, previously translated to a Spanish Peruvian version. Then we compared the results by direct observation, done by a blind researcher, of 12 activities. Statistical analysis: The coefficient of correlation of Pearson was applied. Results: The mean of the HAQ was 0.50 (scale 0-3) range 0.00-1.87, of observed incapacity was 0.45 (0.00 - 1.58) (r0.86, p<0.0001). Conclusion: There is a good correlation between referred and observed functional incapacity. With some modifications the Functional Incapacity Index of the Peruvian version of the HAQ should be applied to more Peruvian patients with with RA, for a long-term, for further validation.Objetivo: Estandarizar la versión peruana del Índice de Incapacidad Funcional del Cuestionario de Evaluación de salud [Health Assessment Questionaire (HAQ)] en pacientes de 3 hospitales de Lima – Perú. Material y Métodos: A 41 pacientes con artritis Reumatoide, según los criterios del colegio americano de Reumatología se les aplicó el HAQ, para medir el grado de incapacidad funcional {Incapacidad referida (Ir)} y se comparó con una observación directa de 12 actividades {Incapacidad observada (Io)}. Análisis Estadístico: Con el coeficiente de correlación de Pearson entre la Ir y la Io. Resultado: El promedio del Cuestionario fue 0,50 (Escala de 0-3) rango de 0,00 a 1,87, el resultado promedio de la observación directa fue 0,45 (0,00 – 1,58) (r=0,86, p<0,0001). Conclusión: La buena correlación entre lo referido y lo observado, hace que el HAQ – versión Peruana deba ser aplicado a un número mayor de pacientes y por un período más prolongado para confirmar esta validación

Estandarización de la versión Peruana del Índice de Incapacidad Funcional del Cuestionario de Evaluación de Salud (Health Assesment Questionnaire - HAQ)

Objective: Standarization of a Peruvian version for the functional incapacity Index of the Health Assessment Questionaire (HAQ). Material and Methods: Forty one patients with Rheumatoid Arthritis, from 3 different Hospitals of Lima, were evaluated. All of them underwent HAQ, previously translated to a Spanish Peruvian version. Then we compared the results by direct observation, done by a blind researcher, of 12 activities. Statistical analysis: The coefficient of correlation of Pearson was applied. Results: The mean of the HAQ was 0.50 (scale 0-3) range 0.00-1.87, of observed incapacity was 0.45 (0.00 - 1.58) (r0.86, p<0.0001). Conclusion: There is a good correlation between referred and observed functional incapacity. With some modifications the Functional Incapacity Index of the Peruvian version of the HAQ should be applied to more Peruvian patients with with RA, for a long-term, for further validation.Objetivo: Estandarizar la versión peruana del Índice de Incapacidad Funcional del Cuestionario de Evaluación de salud [Health Assessment Questionaire (HAQ)] en pacientes de 3 hospitales de Lima – Perú. Material y Métodos: A 41 pacientes con artritis Reumatoide, según los criterios del colegio americano de Reumatología se les aplicó el HAQ, para medir el grado de incapacidad funcional {Incapacidad referida (Ir)} y se comparó con una observación directa de 12 actividades {Incapacidad observada (Io)}. Análisis Estadístico: Con el coeficiente de correlación de Pearson entre la Ir y la Io. Resultado: El promedio del Cuestionario fue 0,50 (Escala de 0-3) rango de 0,00 a 1,87, el resultado promedio de la observación directa fue 0,45 (0,00 – 1,58) (r=0,86, p<0,0001). Conclusión: La buena correlación entre lo referido y lo observado, hace que el HAQ – versión Peruana deba ser aplicado a un número mayor de pacientes y por un período más prolongado para confirmar esta validación

Clinical features, damage accrual, and survival in patients with familial systemic lupus erythematosus: data from a multi-ethnic, multinational Latin American lupus cohort

Objectives This study aimed to compare the clinical features, damage accrual, and survival of patients with familial and sporadic systemic lupus erythematosus (SLE). Methods A multi-ethnic, multinational Latin American SLE cohort was studied. Familial lupus was defined as patients with a first-degree SLE relative; these relatives were interviewed in person or by telephone. Clinical variables, disease activity, damage, and mortality were compared. Odds ratios (OR) and 95% confidence intervals (CI) were estimated. Hazard ratios (HR) were calculated using Cox proportional hazard adjusted for potential confounders for time to damage and mortality. Results A total of 66 (5.6%) patients had familial lupus, and 1110 (94.4%) had sporadic lupus. Both groups were predominantly female, of comparable age, and of similar ethnic distribution. Discoid lupus (OR = 1.97; 95% CI 1.08-3.60) and neurologic disorder (OR = 1.65; 95% CI 1.00-2.73) were significantly associated with familial SLE; pericarditis was negatively associated (OR = 0.35; 95% CI 0.14-0.87). The SLE Disease Activity Index and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) were similar in both groups, although the neuropsychiatric (45.4% vs. 33.5%;p = 0.04) and musculoskeletal (6.1% vs. 1.9%;p = 0.02) domains of the SDI were more frequent in familial lupus. They were not retained in the Cox models (by domains). Familial lupus was not significantly associated with damage accrual (HR = 0.69; 95% CI 0.30-1.55) or mortality (HR = 1.23; 95% CI 0.26-4.81). Conclusion Familial SLE is not characterized by a more severe form of disease than sporadic lupus. We also observed that familial SLE has a higher frequency of discoid lupus and neurologic manifestations and a lower frequency of pericarditis