Thermal effects on chaotic directed transport

We study a chaotic ratchet system under the influence of a thermal environment. By direct integration of the Lindblad equation we are able to analyze its behavior for a wide range of couplings with the environment, and for different finite temperatures. We observe that the enhancement of the classical and quantum currents due to temperature depend strongly on the specific properties of the system. This makes difficult to extract universal behaviors. We have also found that there is an analogy between the effects of the classical thermal noise and those of the finite $\hbar$ size. These results open many possibilities for their testing and implementation in kicked BECs and cold atoms experiments.Comment: 5 pages, 4 figure

Weyl law for fat fractals

It has been conjectured that for a class of piecewise linear maps the closure of the set of images of the discontinuity has the structure of a fat fractal, that is, a fractal with positive measure. An example of such maps is the sawtooth map in the elliptic regime. In this work we analyze this problem quantum mechanically in the semiclassical regime. We find that the fraction of states localized on the unstable set satisfies a modified fractal Weyl law, where the exponent is given by the exterior dimension of the fat fractal.Comment: 8 pages, 4 figures, IOP forma

Spectral behavior of contractive noise

We study the behavior of the spectra corresponding to quantum systems subjected to a contractive noise, i.e. the environment reduces the accessible phase space of the system, but the total probability is conserved. We find that the number of long lived resonances grows as a power law in $\hbar$ but surprisingly there is no relationship between the exponent of this power law and the fractal dimension of the corresponding classical attractor. This is in disagreement with the predictions of the fractal Weyl law which has been established for open systems where the probability is lost under the effect of a projective noise.Comment: 5 pages, 8 figure

Body composition by simple anthropometry, bioimpedance and DXA in preschool children: interrelationships among methods

Objetivo. Comparar la composición corporal estimada por dos métodos antropométricos simples y por impedanciometría (BIA, por sus siglas en inglés) y absorciometría de doble haz de rayos X (DXA, por sus siglas en inglés) y estudiar las correlaciones existentes entre ellos, en una población preescolar de Argentina. Población, material y métodos. Se estudió transversalmente una población clínicamente sana, de edad comprendida entre 4 y 6 años, de 230 niños (118 varones y 112 niñas), que concurrían a Jardines Integrales de La Matanza, Argentina. Se determinó el índice de masa corporal (IMC), la circunferencia de cintura (Cci) y el contenido de grasa corporal, expresado como porcentaje, por BIA (Maltron BF900) y por DXA (densitómetro Lunar DPX-L, software pediátrico). Resultados. En IMC y Cci no se observaron diferencias estadísticamente significativas entre ambos sexos, pero sí en el porcentaje de grasa corporal por BIA o DXA. La correlación entre BIA y ambos métodos antropométricos fue moderada (r de Pearson= 0,43-0,53), al igual que entre DXA y Cci (r= 0,66), mientras que las demás correlaciones fueron fuertes (r= 0,71-0,83). Las medidas obtenidas por BIA y DXA no concordaron (prueba de Bland Altman); sin embargo, las diferencias se distribuyeron en forma homogénea a lo largo del eje horizontal e independientemente de las medias. BIA reprodujo valores más bajos de porcentaje de grasa corporal que DXA (p <0,0001). Conclusiones. Existe buena correlación entre los métodos antropométricos sencillos y la bioimpedancia y DXA. Sin embargo, los resultados no son intercambiables, incluso entre BIA y DXA.Objective.To examine the interrelationships of body composition variables derived from simple anthropometry, bioelectrical impedance (BIA) and dualenergy X-ray absorptiometry (DXA). Population, material and methods. A total of 230 healthy preschool children (118 males and 112 females) age 4-6 years, attending a day care center, were examined to determine body mass index (BMI) and waist circumference (WC). Percentage of body fat content (%BF) was predicted by BIA (Maltron BF900) and DXA (Lunar DPX-L, pediatric software). Results. BMI and WC did not show significant differences among sex, while %BF by BIA or DXA did. BIA measures were lower than DXA´s (p <0.0001). Correlation between BIA vs. anthropometric methods and WC vs. DXA were moderate (Pearson r= 0.43 to 0.53), whereas the other correlations were strong (r= 0.71 to 0.83). However Bland Altman comparison showed wide limits of agreement between BIA and DXA; BIA significantly underestimated %BF as determined by DXA (p <0.0001). Conclusion. The methods used to estimate body composition in healthy preschool children highly correlated. However, the Bland Altman procedure suggests that BIA and DXA should not be used interchangeably.Fil: Rodriguez, Patricia N.. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Bioquímica General y Bucal; ArgentinaFil: Bermúdez, Enrique E.. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Bioquímica General y Bucal; ArgentinaFil: Rodriguez, Gabriela Soledad. Hospital del Niño; ArgentinaFil: Spina, Maria A.. Hospital del Niño; ArgentinaFil: Zeni, Susana Noemi. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Bioquímica General y Bucal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Friedman, Silvia María. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Bioquímica General y Bucal; ArgentinaFil: Exeni, Ramón Alfonso. Hospital del Niño; Argentin

Actinomicosis periapical con resistencia a las penicilinas

La actinomicosis es una enfermedad comúnmente causada por el Actinomyces israelii, bacteria anaeróbica grampositiva habitante normal de la cavidad bucal. La infección aparece generalmente después de un trauma, cirugía o una infección previa aunque extracciones dentarias, cirugía periodontales e infecciones orales predisponen al desarrollo de esta enfermedad. El tratamiento habitual es la eliminación de la causa acompañado de antibioticoterapia con penicilinas.Facultad de Odontologí

Actinomicosis periapical con resistencia a las penicilinas

La actinomicosis es una enfermedad comúnmente causada por el Actinomyces israelii, bacteria anaeróbica grampositiva habitante normal de la cavidad bucal. La infección aparece generalmente después de un trauma, cirugía o una infección previa aunque extracciones dentarias, cirugía periodontales e infecciones orales predisponen al desarrollo de esta enfermedad. El tratamiento habitual es la eliminación de la causa acompañado de antibioticoterapia con penicilinas.Facultad de Odontologí

¿Y si nos vacunamos?

Introducción: Es publicamente conocido que los adultos que superan los 65 años forman parte de la población de mayor riesgo de numerosas enfermedades, entre ella Covid-19. El promedio de edad de los fallecidos por esta virosis es de aproximadamente 73 años. Además, la presencia de otras infecciones como influenza, neumonia, sepsis generalizada, hepatitis, aumentan las posibilidades de contraer la enfermedad causada por el SARS-CoV-2 y la agravan. Aunque aún la vacuna contra este coronavirus esta en desarrollo, ya existen las que previenen los demás cuadros infecciosos antes mencionados. Objetivos:Generar conciencia en la prevención de enfermedades a partir de las vacunas en los adultos mayores de 65 años y su entorno familiar y reafirmar/actualizar informacion sobre Covid-19 y su prevencion.Facultad de Odontologí

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

We identified rare coding variants associated with Alzheimer’s disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants (P<1×10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations (P<5×10-8) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P=5.38×10-10, OR=0.68, MAFcases=0.0059, MAFcontrols=0.0093), a risk variant in ABI3 (rs616338/p.S209F, P=4.56×10-10, OR=1.43, MAFcases=0.011, MAFcontrols=0.008), and a novel GWS variant in TREM2 (rs143332484/p.R62H, P=1.55×10-14, OR=1.67, MAFcases=0.0143, MAFcontrols=0.0089), a known AD susceptibility gene. These protein-coding changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified AD risk genes. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to AD development