Preparation and Characterization of Antibacterial Polypropylene Meshes with Covalently Incorporated β-Cyclodextrins and Captured Antimicrobial Agent for Hernia Repair.

Polypropylene (PP) light weight meshes are commonly used as hernioplasty implants. Nevertheless, the growth of bacteria within textile knitted mesh intersections can occur after surgical mesh implantation, causing infections. Thus, bacterial reproduction has to be stopped in the very early stage of mesh implantation. Herein, novel antimicrobial PP meshes grafted with β-CD and complexes with triclosan were prepared for mesh infection prevention. Initially, PP mesh surfaces were functionalized with suitable cold oxygen plasma. Then, hexamethylene diisocyanate (HDI) was successfully grafted on the plasma-activated PP surfaces. Afterwards, β-CD was connected with the already HDI reacted PP meshes and triclosan, serving as a model antimicrobial agent, was loaded into the cyclodextrin (CD) cavity for desired antibacterial functions. The hydrophobic interior and hydrophilic exterior of β-CD are well suited to form complexes with hydrophobic host guest molecules. Thus, the prepared PP mesh samples, CD-TCL-2 and CD-TCL-6 demonstrated excellent antibacterial properties against Staphylococcus aureus and Escherichia coli that were sustained up to 11 and 13 days, respectively. The surfaces of chemically modified PP meshes showed dramatically reduced water contact angles. Moreover, X-ray diffractometer (XRD), differential scanning calorimeter (DSC), and Thermogravimetric (TGA) evidenced that there was no significant effect of grafted hexamethylene diisocyanate (HDI) and CD on the structural and thermal properties of the PP meshes

Charge recycling 8T SRAM design for low voltage robust operation

It is attractive to design power efficient and robust SRAM in low voltage and high performance systems for mobile or battery-powered electronics. To reduce the power consumption resulting from bit-line activities, a new bit-line charge recycling circuit is proposed for 8T SRAMs. By eliminating the use of analog blocks required in existing circuits in literature, this proposed charge recycling scheme results in less design complexity. In addition, two types of SRAM cells are employed to improve the robustness in write operation, and hierarchical bit-line structure is applied to reduce the power consumption in read operation. Post-layout simulations demonstrate the proposed design results in 3.08 and 2.62 times enhancement of WSNM and SWN compared to conventional 6T SRAM design in the same technology, respectively. The power consumption of proposed design results in a reduction of 64.2% and 27.5% in write and read power consumption compared to 6T SRAM design. Moreover, given the same supply voltage (e.g., 1.2 V), post-layout simulation shows the proposed design is able to run at 5 times higher clock rate than the existing designs in literature. Given the same clock frequency requirement (e.g., 100 MHz), a lower supply voltage (e.g., 0.7 V) can sustain robust operation of the proposed design

Boer-Mulders effect in the unpolarized pion induced Drell-Yan process at COMPASS within TMD factorization

We investigate the theoretical framework of the $\cos 2\phi$ azimuthal asymmetry contributed by the coupling of two Boer-Mulders functions in the dilepton production unpolarized $\pi p$ Drell-Yan process by applying the transverse momentum dependent factorization at leading order. We adopt the model calculation results of the unpolarized distribution function $f_1$ and Boer-Mulders function $h_1^\perp$ of pion meson from the light-cone wave functions. We take into account the transverse momentum evolution effects for both the distribution functions of pion and proton by adopting the existed extraction of the nonperturbative Sudakov form factor for the pion and proton distribution functions. An approximate kernel is included to deal with the energy dependence of the Boer-Mulders function related twist-3 correlation function $T_{q,F}^{(\sigma)}(x,x)$ needed in the calculation. We numerically estimate the Boer-Mulders asymmetry $\nu_{BM}$ as the functions of $x_p$, $x_\pi$, $x_F$ and $q_T$ considering the kinematics at COMPASS Collaboration.Comment: 11 pages, 2 figures, typos correcte

Controlled Levofloxacin Release and Antibacterial Properties of β-Cyclodextrins-Grafted Polypropylene Mesh Devices for Hernia Repair.

Mesh infection is a major complication of hernia repair. After knitted mesh implantation, bacteria can grow within textile structures causing infection. In this work, polypropylene (PP) mesh devices were two-step grafted with hexamethylene diisocyanate (HDI) and β⁻cyclodexrins (CD) and then loaded with suitable antimicrobial levofloxacin HCL for hernia mesh-infection prevention. First, oxygen plasma was able to create surface roughness, then HDI was successfully grafted onto PP fiber surfaces. Afterwards, CD was covalently grafted onto the HDI treated PP meshes, and levofloxacin HCL (LVFX) was loaded into the CD cavity of the modified meshes. The modified devices were evaluated for sustained antibiotic properties and drug-release profiles in a phosphate buffer, and sustained drug release was observed between interfaces of meshes and aqueous environment. The antibiotic-loaded PP mesh samples demonstrated sustained antibacterial properties for 7 and 10 days, respectively, against both Gram-negative and Gram-positive bacteria. The CD-captured levofloxacin HCL showed burst release after 6 h but later exhibited sustained release for the next 48 h. Among all samples, the modified mesh LVFX-6 was more stable and showed more sustained drug release and could be employed in future clinical applications

An Extended VIKOR Method for Multiple Criteria Group Decision Making with Triangular Fuzzy Neutrosophic Numbers

In this article, we combine the original VIKOR model with a triangular fuzzy neutrosophic set to propose the triangular fuzzy neutrosophic VIKOR method. In the extended method, we use the triangular fuzzy neutrosophic numbers (TFNNs) to present the criteria values in multiple criteria group decision making (MCGDM) problems. Firstly, we summarily introduce the fundamental concepts, operation formulas and distance calculating method of TFNNs. Then we review some aggregation operators of TFNNs. Thereafter, we extend the original VIKOR model to the triangular fuzzy neutrosophic environment and introduce the calculating steps of the TFNNs VIKOR method, our proposed method which is more reasonable and scientific for considering the conflicting criteria. Furthermore, a numerical example for potential evaluation of emerging technology commercialization is presented to illustrate the new method, and some comparisons are also conducted to further illustrate advantages of the new method

Power Efficient SRAM Design with Integrated Bit Line Charge Pump

Bit line toggling of SRAM systems in write operations leads to the largest portion of power dissipation. To reduce this amount of power loss and achieve power efficient memory, we propose a new SRAM design that integrates charge pump circuits to harvest and reuse bit line charge. In this work, a power-efficient charge recycling SRAM is designed and implemented in 180nm CMOS technology. Post-layout simulation demonstrates an 11% of power saving and 3.8% of area overhead, if the bit width of SRAM is chosen as 8. Alternatively, 22% of power reduction is obtained if the bit width of SRAM is extended to 64. Compared with existing charge recycling SRAM schemes, this proposed SRAM is robust to process variation, demonstrates good read/write stability, and illustrates better trade-off between design complexity and power reduction

ON THE SPECTRAL INSTABILITY AND BIFURCATION OF 2D-QUASI-GEOSTROPHIC POTENTIAL VORTICITY EQUATION

The analysis on hydrodynamic stability of shear flows is an active research direction in fluid dynamics. In this article, the spectral instability and bifurcation of forced shear flows governed by the 2D quasi-geostrophic equation with a generalized Kolmogorov forcing are investigated. We prove that the corresponding eigenvalue problem can be transferred into a family of algebraic equations with infinity number of variables, and the nontrivial solutions to the algebraic equations are expressed in form of continuous fractions. After obtaining the asymptotic estimate for the ratio of the imaginary parts of eigenvalues to a control parameter R as it approaches to infinity, we show that there exists a critical value Rc above which, the forced shear flows become unstable, where the control parameter R is the product of Reynolds number Re and the intensity of the curl of the forcing. To shed light on the bifurcation involved in the losing stability of the forced shear flows, a natural method used to reduce the quasi-geostrophic equation to ODEs is introduced. Based on numerical experiments on the coefficients in the ODEs, we show that both supercritical and subcritical Hopf bifurcations occur in the forced shear flows, which only depend on the type of generalized Kolmogorov forcing