« La plus noble peinture est un poème peint » : traduire pour peindre. Dante Gabriel Rossetti lecteur de Dante

«Life imitates Art far more than Art imitates Life», Oscar Wilde said. Dante Gabriel Rossetti’s translation of Dante Alighieri’s poetry may be read as a seminal life experience, which sets the pattern and method of a process of imitative self-creation. One might say that Rossetti lived his Dante. This study would suggest that Rossetti inverted the traditional ut pictura poesis into a dynamics of writing, in poetry and painting alike, aiming at faithfulness not to the subject matter but to the “new life” of the emerging virtual self. Elizabeth Siddal was Rossetti’s real-life Beatrice, and love transcended and transformed their lives into art. This study is an attempt to examine another form of two-way transmediality: between life and art, βιός and τέχνη, as the epitome of inspiration lived as pneumatic circulation or spiritual exaltation (Aristote, Agamben). In an attempt to suggest a different approach to Rossetti’s life and work as life-creation, this paper pays all due respect to previous Rossetti scholarship, although it cannot afford the space to synthetize them all.« La vie imite l’art bien plus que l’art imite la nature », disait Oscar Wilde. La traduction des poèmes de Dante Alighieri par Dante Gabriel Rossetti peut se lire comme une expérience de vie, qui pose le modèle et la méthode d’un processus de création de soi. On peut dire que Rossetti vivait son Dante. Cette étude suggère que Rossetti inversa l’ut pictura poesis traditionnel en une dynamique d’écriture, en poésie comme en peinture, visant la fidélité non pas au sujet mais à la « nouvelle vie » du soi virtuel émergeant. Elizabeth Siddal fut la Béatrice vivante de Rossetti, et l’amour transcenda et transforma leurs vies en art. Cette étude tente d’examiner une autre forme de transmédialité réciproque, entre la vie et l’art, entre βιός et τέχνη, épitomé de l’inspiration vécue comme circulation pneumatique ou exaltation spirituelle (Aristote, Agamben). Dans une tentative de suggérer une approche différente de la vie et de l’œuvre de Rossetti comme création vitale, cet article fait grand cas des études existantes, sans avoir la place nécessaire pour les synthétiser toutes

Amor maldito, motor da poesia: a Provença e a modernidade

C’est la composition des vidas des troubadours qui confère au Grand Chant la dimension romanesque et fictionnelle qui a permis la construction d’un certain nombre de figures “maudites”: Jaufre Rudel, Bertrand de Born, Raimon Jordan... L’amour chanté par le trobar engendre son opposé destructeur: la mélancolie due à l’éloignement de la dame guette le troubadour, qui risque de ne plus savoir composer. Cette réflexion pousse les modernistes américains, Ezra Pound, Haroldo et Augusto de Campos, entre autres, à reconnaître en la Provence des XIIe et XIIIe siècles le lieu originaire, le topos outopos de la poésie.É a composição das vidas dos trovadores que confere ao Grand Chant a dimensão romanesca e ficcional que permitiu a construção de figuras “malditas” como Jaufre Rudel, Bertrand de Born, Raimon Jordan... Do amor cantado pelo trobar nasce o seu oposto destruidor: a melancolia, decorrente da ausência da dama, espreita o trovador, acenando-lhe o risco de não mais compor. tal reflexão vai conduzir autores como Ezra pound, Haroldo e Augusto de Campos a reconhecer na provence dos séculos XII a XIII o lugar original, o topos outopos da poesia.It is the composition of the troubadours’ lives that confers to the Grand Chant a Romanesque and fictional dimension that allowed the construction of “damned” figures such as Jaufre Rudel, Bertrand de Born, Guillem de Berguedan, Folquet de Marseille, Raimon Jordan... From the love sung by the trobar, its destructive opposite is born -- melancholy, resulting from the lady’s absence, awaits the minstrel, waiving at him the risk of no longer composing. Such reflection will lead authors as Ezra Pound, Haroldo and Augusto de Campos, to recognize in the Provence of the 12th-13th centuries the original place, the topos outopos of poetry

: Une lecture de Foucault et de Derrida

International audienceDans un entretien avec Jean-Luc Nancy intitulé « Après le sujet qui vient », Derrida affirme : « La singularité du “qui” n’est pas l’individualité d’une chose identique à elle-même, ce n’est pas un atome. Elle se disloque ou se divise en se rassemblant pour répondre à l’autre, dont l’appelle précède en quelque sorte sa propre identification à soi parce qu’à cet appel je ne peux que répondre, avoir déjà répondu, même si je crois y répondre “non” [...] ».Dans le même entretien, Derrida souligne que ce que l’on appelle avec beaucoup de facilité le refus de la subjectivité n’est pas une opération simple qui va de soi, et les philosophes qui semblent la dépasser, Lacan, Althusser, Foucault, Freud, Marx, Nietzsche, sont loin d’y parvenir. Le sujet n’est pas prêt à quitter le lieu du débat. Nonobstant l’impossibilité de définir la présence à soi de celui-ci, force nous est de constater que, identique à lui-même ou fendu, la notion de subjectivité demeure, comme le démontre le titre du cours que Foucault donne au Collège de France en 1981-1982 sous le titre « L’herméneutique du sujet ». Le philosophe définit la problématique de son cours par les mots de « sujet et vérité ». Son séminaire tourne plus précisément autour de l’histoire de la notion de « souci de soi-même » que la philosophie occidentale aurait mise de côté, à partir d’un certain « moment cartésien », pour lui préférer la « fameuse prescription delphique » : « connais-toi toi-même »

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes nuclear and mitochondrial DNA damage, denaturation of intracellular proteins, lipid peroxidation and inflammation. Oxidative or nitrosative stress-mediated injury lead to cardiomyocytes apoptosis or necrosis. The reactive oxygen (ROS) and nitrogen species (RNS) concentration is dependent on their production and on the expression and activity of anti-oxidant enzymes. Polyphenols are a large group of natural compounds ubiquitously expressed in plants, and epidemiological studies have shown associations between a diet rich in polyphenols and the prevention of various ROS-mediated human diseases. Polyphenols reduce cardiomyocytes damage, necrosis, apoptosis, infarct size and improve cardiac function by decreasing oxidative stress-induced production of ROS or RNS. These effects are achieved by the ability of polyphenols to modulate the expression and activity of anti-oxidant enzymes and several signaling pathways involved in cells survival. This report reviews current knowledge on the potential anti-oxidative effects of polyphenols to control the cardiotoxicity induced by ROS and RNS stress

Management at the service of research: ReOmicS, a quality management system for omics sciences

AbstractManagement and research represent a binomial almost unknown, whose potentialities and requirements have not yet been fully exploited even if, recently, the scientific and social communities have felt the burden of producing results and data requiring at the same time reproducibility, reliability, safety and efficacy of the discoveries, as well as a profitable use of resources. A Quality Management System (QMS) could represent a valid tool for these purposes, improving the quality of the research. The research community could ask whether and how it is possible to apply this approach in a research laboratory without hindering their creativity, and what the possible benefits might be. On the other hand, an international standard for a quality management system appropriate for a research laboratory is yet to come. The choice, the design and the application of a QMS, inspired by the Good Laboratory Practices, in a research laboratory specialized on "omics" sciences, is fully described in this paper. Its application has already shown good outcomes as testified by specific metric of efficiency and effectiveness. The approach is innovative as there is no obvious requirement for research laboratories to develop and define quality objectives. The paper highlights how the QMS approach enhances the relationship with public and private sectors by increasing customer confidence and loyalty, as well as improving the overall performance of the laboratory in terms of throughput and value of research. These results encourage proposing it as a QMS model providing a new and scalable operational strategy to be applied in a research environment with the same target and even in a generic research laboratory

Profiling RNA editing in human tissues: towards the inosinome Atlas

Adenine to Inosine RNA editing is a widespread co- and post-transcriptional mechanism mediated by ADAR enzymes acting on double stranded RNA. It has a plethora of biological effects, appears to be particularly pervasive in humans with respect to other mammals, and is implicated in a number of diverse human pathologies. Here we present the first human inosinome atlas comprising 3,041,422 A-to-I events identified in six tissues from three healthy individuals. Matched directional total-RNA-Seq and whole genome sequence datasets were generated and analysed within a dedicated computational framework, also capable of detecting hyper-edited reads. Inosinome profiles are tissue specific and edited gene sets consistently show enrichment of genes involved in neurological disorders and cancer. Overall frequency of editing also varies, but is strongly correlated with ADAR expression levels. The inosinome database is available at: http://srv00.ibbe.cnr.it/editing/

VNIR spectral analyses of powdered mixtures with ExoMars-Ma_Miss instrument

Ma_Miss (Mars Multispectral Imager for Subsurface Studies) experiment onboard of ExoMars 2018 mission to Mars will study the Martian subsurface down to a depth of 2 meters [1]. Ma_Miss is a miniaturized spectrometer, integrated within the drilling system of the ExoMars rover; it will perform visible and near infrared spectroscopy in the 0.4-2.2 μm range, acquiring signal from the excavated borehole wall. The spectroscopic characterization of the subsurface rocks will give us important information about mineralogy, petrology and geological processes; moreover it will give insights about materials that have not been altered by surface processes such as erosion, weathering or oxidation. Spectroscopic measurements have been performed on different types of rock/mineral mixtures with the Ma_Miss laboratory model (breadboard). <P /

Visible and Infrared Spectroscopy of Grosvenor Mountains 95535, howardite

In order to strengthen the linkage between Vesta and HED spectral composition, a set of HED meteorites (33 samples) have been investigated with different laboratory setups at INAF-IAPS. Among these, the SPectral IMager facility is a laboratory VIS-IR spectrometer [1] developed to support the DAWN mission [2], which is now in orbit around Ceres. Here, we report reflectance spectral data related to powdered samples (<75μm) of one howardite, Grosvenor Mountain 95535, measured by means of the SPIM facility. <P /

The ETS Homologous Factor (EHF) Represents a Useful Immunohistochemical Marker for Predicting Prostate Cancer Metastasis.

The main aim of this study was to investigate the risk of prostate cancer metastasis formation associated with the expression of ETS homologous factor (EHF) in a cohort of bioptic samples. To this end, the expression of EHF was evaluated in a cohort of 152 prostate biopsies including primary prostate cancers that developed metastatic lesions, primary prostate cancers that did not develop metastasis, and benign lesions. Data here reported EHF as a candidate immunohistochemical prognostic biomarker for prostate cancer metastasis formation regardless of the Gleason scoring system. Indeed, our data clearly show that primary lesions with EHF positive cells ≥40% had a great risk of developing metastasis within five years from the first diagnosis. Patients with these lesions had about a 40-fold increased risk of developing metastasis as compared with patients with prostate lesions characterized by a percentage of EHF positive cells ≤30%. In conclusion, the immunohistochemical evaluation of EHF could significantly improve the management of prostate cancer patients by optimizing the diagnostic and therapeutic health procedures and, more important, ameliorating the patient's quality of life

Analysis of Rocks Slabs by VNIR Spectroscopy and Linear Mixing with Ma_Miss Instrument Breadboard

Ma_Miss, integrated inside the ExoMars-2018 Rover Drill, is a miniaturized VIS-NIR spectrometer for the investigation of the martian shallow subsurface