The need for isotopic data on refractory elements in the solar wind

The Sun accounts for the bulk of material in the solar system. Information on the isotopic composition of elements in the solar wind is therefore essential for an understanding of the contribution made by each nucleogenetic component that has been identified in meteorites. Recent work suggests that isotopic data on the solar wind may also help us to understand the physical process that is concentrating light elements at the solar surface. Refractory and volatile elements would behave alike under the conditions of solar fractionation. Prolonged exposure of foils at 1AU from the sun would be a relatively inexpensively way to collect the quantity of solar wind implanted refractory elements needed to test this hypothesis

Search for Neutrinoless Double Beta Decay with NEMO 3 and SuperNEMO

Since 2003 the NEMO~3 experiment has been searching for neutrinoless double beta decay using about 10 kg of enriched isotopes. A limit of T_(1/2)(0nu) > 5.8 10**23 years at 90 % CL has been obtained for 100-Mo from the first two years of data. Several measurements of two-neutrino double beta decays have also been performed. A first NEMO 3 measurement of the half-life of 130-Te is presented, giving a value of T_(1/2)(2nu) = (7.6 +- 1.5 (stat) +- 0.8 (syst)) 10**20 years. In parallel, there is an active R&D programme for the SuperNEMO experiment which is expected to commence data taking in 2012-2013 with 100-200 kg of enriched isotopes.Comment: 6 pages, 3 figures, Proceedings of the 2007 Europhysics Conference on High Energy Physics, in Manchester, England, 19-25 July 200

Existence and Stability of Non-Trivial Scalar Field Configurations in Orbifolded Extra Dimensions

We consider the existence and stability of static configurations of a scalar field in a five dimensional spacetime in which the extra spatial dimension is compactified on an $S^1/Z_2$ orbifold. For a wide class of potentials with multiple minima there exist a finite number of such configurations, with total number depending on the size of the orbifold interval. However, a Sturm-Liouville stability analysis demonstrates that all such configurations with nodes in the interval are unstable. Nodeless static solutions, of which there may be more than one for a given potential, are far more interesting, and we present and prove a powerful general criterion that allows a simple determination of which of these nodeless solutions are stable. We demonstrate our general results by specializing to a number of specific examples, one of which may be analyzed entirely analytically.Comment: 23 pages, 7 figures, references added, factor of two corrected in kink energy definition, submitted to PR

Non-equilibrium transition from dissipative quantum walk to classical random walk

We have investigated the time-evolution of a free particle in interaction with a phonon thermal bath, using the tight-binding approach. A dissipative quantum walk can be defined and many important non-equilibrium decoherence properties can be investigated analytically. The non-equilibrium statistics of a pure initial state have been studied. Our theoretical results indicate that the evolving wave-packet shows the suppression of Anderson's boundaries (ballistic peaks) by the presence of dissipation. Many important relaxation properties can be studied quantitatively, such as von Neumann's entropy and quantum purity. In addition, we have studied Wigner's function. The time-dependent behavior of the quantum entanglement between a free particle -in the lattice- and the phonon bath has been characterized analytically. This result strongly suggests the non-trivial time-dependence of the off-diagonal elements of the reduced density matrix of the system. We have established a connection between the quantum decoherence and the dissipative parameter arising from interaction with the phonon bath. The time-dependent behavior of quantum correlations has also been pointed out, showing continuous transition from quantum random walk to classical random walk, when dissipation increases.Comment: Submitted for publication. 17 pages, 6 figure

Infections after chimeric antigen receptor (CAR)-T-cell therapy for hematologic malignancies.

Chimeric antigen receptor (CAR)-T-cell therapies have revolutionized the management of acute lymphoblastic leukemia, non-Hodgkin lymphoma, and multiple myeloma but come at the price of unique toxicities, including cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, and long-term "on-target off-tumor" effects. All of these factors increase infection risk in an already highly immunocompromised patient population. Indeed, infectious complications represent the key determinant of non-relapse mortality after CAR-T cells. The temporal distribution of these risk factors shapes different infection patterns early versus late post-CAR-T-cell infusion. Furthermore, due to the expression of their targets on B lineage cells at different stages of differentiation, CD19, and B-cell maturation antigen (BCMA) CAR-T cells induce distinct immune deficits that could require different prevention strategies. Infection incidence is the highest during the first month post-infusion and subsequently decreases thereafter. However, infections remain relatively common even a year after infusion. Bacterial infections predominate early after CD19, while a more equal distribution between bacterial and viral causes is seen after BCMA CAR-T-cell therapy, and fungal infections are universally rare. Cytomegalovirus (CMV) and other herpesviruses are increasingly breported, but whether routine monitoring is warranted for all, or a subgroup of patients, remains to be determined. Clinical practices vary substantially between centers, and many areas of uncertainty remain, including CMV monitoring, antibacterial and antifungal prophylaxis and duration, use of immunoglobulin replacement therapy, and timing of vaccination. Risk stratification tools are available and may help distinguish between infectious and non-infectious causes of fever post-infusion and predict severe infections. These tools need prospective validation, and their integration in clinical practice needs to be systematically studied

Restoration of tropical seagrass beds using wild bird fertilization and sediment regrading

Shallow water seagrass meadows are frequently damaged by recreational and commercial vessels. Severe injury occurs where propeller scarring, hull groundings and mooring anchors uproot entire plants, excavate sediments, and modify the biophysical properties of the substrate. In climax tropical seagrass communities dominated by Thalassia testudinum (turtlegrass), natural recovery in these disturbances can take several years to decades, and in some environmental conditions may not occur at all. During the recovery period, important ecological services provided by seagrasses are absent or substantially diminished and injured meadows can degrade further in response to natural disturbances, e.g. strong currents and severe storms. To determine if we could accelerate rehabilitation and prevent further degradation of injured turtlegrass meadows, we evaluated a restoration method called “modified compressed succession” using the fast-growing, opportunistic species Halodule wrightii to temporarily substitute ecological services for the slower-growing, climax species T. testudinum. In three experiments we showed statistically significant increases in density and coverage rates of H. wrightii transplants fertilized by wild bird feces as compared to unfertilized treatments. In one experiment, we further demonstrated that regrading excavated injuries with sediment-filled biodegradable tubes in combination with wild bird fertilization and H. wrightii transplants also accelerated seagrass recovery. Specific recommendations are presented for the best practical application of this restoration method in the calcium carbonate-based sediments of south Florida and the wider Caribbean region

Recent topics of mesic atoms and mesic nuclei -- ϕ\phi mesic nuclei exist ?--

We study $\phi$-meson production in nuclei to investigate the in-medium modification of the $\phi$-meson spectral function at finite density. We consider (${\bar p},\phi$), ($\gamma,p$) and ($\pi^-,n$) reactions to produce a $\phi$-meson inside the nucleus and evaluate the effects of the medium modifications to reaction cross sections. The structures of the bound states, $\phi$-mesic nuclei, are also studied. For strong absorptive interaction cases, we need to know the spectrum shape in a wide energy region to deduce the properties of $\phi$.Comment: Talk given at EXA08, Vienna, September 2008. To be published in the Proceedings, Hyperfine Interactions. 6 pages, 6 figure

Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium

We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA8 mRNA is expressed in low-proliferative isolated pubertal mouse mammary ductal epithelium and after enforced involution, but not in isolated highly proliferative terminal end buds (TEB) or during pregnancy. To better understand ANXA8’s association with this breast cancer subgroup we established ANXA8’s cellular distribution in the mammary gland and ANXA8’s effect on cell proliferation. We show that ANXA8 expression in the mouse mammary gland was strong during pre-puberty before the expansion of the rudimentary ductal network and was limited to a distinct subpopulation of ductal luminal epithelial cells but was not detected in TEB or in alveoli during pregnancy. Similarly, during late involution its expression was found in the surviving ductal epithelium, but not in the apoptotic alveoli. Double-immunofluorescence (IF) showed that ANXA8 positive (+ve) cells were ER-alpha negative (−ve) and mostly quiescent, as defined by lack of Ki67 expression during puberty and mid-pregnancy, but not terminally differentiated with ~15% of ANXA8 +ve cells re-entering the cell cycle at the start of pregnancy (day 4.5). RT-PCR on RNA from FACS-sorted cells and double-IF showed that ANXA8+ve cells were a subpopulation of c-kit +ve luminal progenitor cells, which have recently been identified as the cells of origin of basal-like breast cancers. Over expression of ANXA8 in the mammary epithelial cell line Kim-2 led to a G0/G1 arrest and suppressed Ki67 expression, indicating cell cycle exit. Our data therefore identify ANXA8 as a potential mediator of quiescence in the normal mouse mammary ductal epithelium, while its expression in basal-like breast cancers may be linked to ANXA8’s association with their specific cells of origin

The Heisenberg model on the 1/5-depleted square lattice and the CaV4O9 compound

We investigate the ground state structure of the Heisenberg model on the 1/5-depleted square lattice for arbitrary values of the first- and second-neighbor exchange couplings. By using a mean-field Schwinger-boson approach we present a unified description of the rich ground-state diagram, which include the plaquette and dimer resonant-valence-bond phases, an incommensurate phase and other magnetic orders with complex magnetic unit cells. We also discuss some implications of ours results for the experimental realization of this model in the CaV4O9 compound.Comment: 4 pages, Latex, 7 figures included as eps file

Functional characterization of generalized Langevin equations

We present an exact functional formalism to deal with linear Langevin equations with arbitrary memory kernels and driven by any noise structure characterized through its characteristic functional. No others hypothesis are assumed over the noise, neither the fluctuation dissipation theorem. We found that the characteristic functional of the linear process can be expressed in terms of noise's functional and the Green function of the deterministic (memory-like) dissipative dynamics. This object allow us to get a procedure to calculate all the Kolmogorov hierarchy of the non-Markov process. As examples we have characterized through the 1-time probability a noise-induced interplay between the dissipative dynamics and the structure of different noises. Conditions that lead to non-Gaussian statistics and distributions with long tails are analyzed. The introduction of arbitrary fluctuations in fractional Langevin equations have also been pointed out