Comparison of medium frequency pulsed radar interferometer and correlation analysis winds, part 2

In order to test whether the chosen Doppler peaks represent localized scatters in motion, as opposed to some sort of integrated composite, an attempt was made to determine the change in position of single scatterers over a series of sequential records. A four-antenna system was employed which had 1 degree of freedom in phase. Due to limitations N-S linear transmission and E-W linear reception were used. The Doppler frequency peak selection criteria were that at least two of the four power spectra should have a local peak, and that normalized phase discrepancy, should be less than 0.3. The lack of success in tracking individual scatters seems to suggest a short lifetime. If this is the case, then the present experiment is not able to resolve the difference found between the correlation analysis true velocity and the interferometer value. On the other hand, it appears that the interferometer may be of some use in tracking waves

Executive remuneration consultancy in the UK: exploring a professional project through the lens of institutional work

This article responds to recent calls to examine the development of professionalism through the lens of institutional theory. We investigate the development of the new professional service of executive remuneration consultancy (ERC) in the UK through the lens of institutional work. Specifically, drawing upon Lawrence and Suddaby (2006) and Suddaby and Viale (2011), we explore the relationship between macro-scale occupational/organizational and micro-scale individual-level dynamics of the ERC professional project and situate its development in relation to the broader field of executive remuneration practices. We show that the institutional work of creating the new professional project is contested and that the ERC development may be better understood as part of broader efforts to create and maintain the institution of executive pay-setting practices. We argue that the institutional work lens has the potential to produce a more nuanced understanding of the internal dynamics of the ERC professionalization process and its role in reconfiguring broader institutional arrangements. By exploring the analytical purchase of the concept of institutional work, the article contributes to the emerging body of empirical evidence outlining the potential of (neo-) institutional approaches to offer a more productive understanding of contemporary professionalis

Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome

Objective: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies in human and murine lupus, and in studies of murine antibodies, a role of mutations at position 53 in VH CDR2 has been demonstrated. We previously demonstrated in vitro expression and mutagenesis of the human IgG1 monoclonal antibody B3. The present study was undertaken to investigate, using this expression system, the importance of the arginine residue at position 53 (R53) in B3 VH. Methods: R53 was altered, by site-directed mutagenesis, to serine, asparagine, or lysine, to create 3 expressed variants of VH. In addition, the germline sequence of the VH3-23 gene (from which B3 VH is derived) was expressed either with or without arginine at position 53. These 5 new heavy chains, as well as wild-type B3 VH, were expressed with 4 different light chains, and the resulting antibodies were assessed for their ability to bind to nucleosomes, -actinin, cardiolipin, ovalbumin, 2-glycoprotein I (2GPI), and the N-terminal domain of 2GPI (domain I), using direct binding assays. Results: The presence of R53 was essential but not sufficient for binding to dsDNA and nucleosomes. Conversely, the presence of R53 reduced binding to -actinin, ovalbumin, 2GPI, and domain I of 2GPI. The combination B3 (R53S) VH/B3 VL bound human, but not bovine, 2GPI. Conclusion: The fact that the R53S substitution significantly alters binding of B3 to different clinically relevant antigens, but that the alteration is in opposite directions depending on the antigen, implies that this arginine residue plays a critical role in the affinity maturation of antibody B3

Measurement Of Magnetic Susceptibility In Pulsed Magnetic Fields Using A Proximity Detector Oscillator

We present a novel susceptometer with a particularly small spatial footprint and no moving parts. The susceptometer is suitable for use in systems with limited space where magnetic measurements may not have been previously possible, such as in pressure cells and rotators, as well as in extremely high pulsed fields. The susceptometer is based on the proximity detector oscillator, which has a broad dynamic resonant frequency range and has so far been used predominantly for transport measurements. We show that for insulating samples, the resonance frequency behavior as a function of field consists of a magnetoresistive and an inductive component, originating, respectively, from the sensor coil and the sample. The response of the coil is modeled, and upon subtraction of the magnetoresistive component the dynamic magnetic susceptibility and magnetization can be extracted. We successfully measure the magnetization of the organic molecular magnets Cu(H2O)(5)(VOF4)(H2O) and [Cu(HF2)(pyz)(2)]BF4 in pulsed magnetic fields and by comparing the results to that from a traditional extraction susceptometer confirm that the new system can be used to measure and observe magnetic susceptibilities and phase transitions. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3653395

Magnetic properties of the S=1/2 quasi square lattice antiferromagnet CuF2(H2O)2(pyz) (pyz=pyrazine) investigated by neutron scattering

We have performed elastic and inelastic neutron experiments on single crystal samples of the coordination polymer compound CuF2(H2O)2(pyz) (pyz=pyrazine) to study the magnetic structure and excitations. The elastic neutron diffraction measurements indicate a collinear antiferromagnetic structure with moments oriented along the [0.7 0 1] real-space direction and an ordered moment of 0.60 +/- 0.03 muB/Cu. This value is significantly smaller than the single ion magnetic moment, reflecting the presence of strong quantum fluctuations. The spin wave dispersion from magnetic zone center to the zone boundary points (0.5 1.5 0) and (0.5 0 1.5) can be described by a two dimensional Heisenberg model with a nearest neighbor magnetic exchange constant J2d = 0.934 +/-0.0025 meV. The inter-layer interaction Jperp in this compound is less than 1.5% of J2d. The spin excitation energy at the (0.5 0.5 0.5) zone boundary point is reduced when compared to the (0.5 1 0.5) zone boundary point by ~10.3 +/- 1.4 %. This zone boundary dispersion is consistent with quantum Monte Carlo and series expansion calculations which include corrections for quantum fluctuations to linear spin wave theory.Comment: 7 pages, 6 figure