Patient and Regimen Characteristics Associated with Self-Reported Nonadherence to Antiretroviral Therapy

BACKGROUND: Nonadherence to antiretroviral therapy (ARVT) is an important behavioral determinant of the success of ARVT. Nonadherence may lead to virological failure, and increases the risk of development of drug resistance. Understanding the prevalence of nonadherence and associated factors is important to inform secondary HIV prevention efforts. METHODOLOGY/PRINCIPAL FINDINGS: We used data from a cross-sectional interview study of persons with HIV conducted in 18 U.S. states from 2000-2004. We calculated the proportion of nonadherent respondents (took <95% of prescribed doses in the past 48 hours), and the proportion of doses missed. We used multivariate logistic regression to describe factors associated with nonadherence. Nine hundred and fifty-eight (16%) of 5,887 respondents reported nonadherence. Nonadherence was significantly (p<0.05) associated with black race and Hispanic ethnicity; age <40 years; alcohol or crack use in the prior 12 months; being prescribed >or=4 medications; living in a shelter or on the street; and feeling "blue" >or=14 of the past 30 days. We found weaker associations with having both male-male sex and injection drug use risks for HIV acquisition; being prescribed ARVT for >or=21 months; and being prescribed a protease inhibitor (PI)-based regimen not boosted with ritonavir. The median proportion of doses missed was 50%. The most common reasons for missing doses were forgetting and side effects. CONCLUSIONS/SIGNIFICANCE: Self-reported recent nonadherence was high in our study. Our data support increased emphasis on adherence in clinical settings, and additional research on how providers and patients can overcome barriers to adherence

Does mobilization of the upper cervical spine affect pain sensitivity and autonomic nervous system function in patients with cervico-craniofacial pain?: A randomized-controlled trial

2.703 JCR (2013) Q2, 8/29 Anesthesiology, 75/194 Clinical neurolog

Autonomic Regulation Therapy in Heart Failure

Autonomic Regulation Therapy (ART) is a rapidly emerging therapy in the management of congestive heart failure secondary to systolic dysfunction. Modulation of the cardiac neuronal hierarchy can be achieved with bioelectronics modulation of the spinal cord, cervical vagus, baroreceptor, or renal nerve ablation. This review will discuss relevant preclinical and clinical research in ART for systolic heart failure. Understanding mechanistically what is being stimulated within the autonomic nervous system by such device-based therapy and how the system reacts to such stimuli is essential for optimizing stimulation parameters and for the future development of effective ART

CSES Module 1 Full Release

The module was administered as a post-election interview. The resulting data are provided along with voting, demographic, district and macro variables in a single dataset. CSES Variable List The list of variables is being provided on the CSES Website to help in understanding what content is available from CSES, and to compare the content available in each module. Themes: MICRO-LEVEL DATA: Identification and study administration variables: weighting factors;election type; date of election 1st and 2nd round; study timing (post election study, pre-election and post-election study, between rounds of majoritarian election); mode of interview; gender of interviewer; date questionnaire administered; primary electoral district of respondent; number of days the interview was conducted after the election Demography: age; gender; education; marital status; union membership; union membership of others in household; current employment status; main occupation; employment type - public or private; industrial sector; occupation of chief wage earner and of spouse; household income; number of persons in household; number of children in household under the age of 18; attendance at religious services; religiosity; religious denomination; language usually spoken at home; race; ethnicity; region of residence; rural or urban residence Survey variables: respondent cast a ballot at the current and the previous election; respondent cast candidate preference vote at the previous election; satisfaction with the democratic process in the country; last election was conducted fairly; form of questionnaire (long or short); party identification; intensity of party identification; political parties care what people think; political parties are necessary; recall of candidates from the last election (name, gender and party); number of candidates correctly named; sympathy scale for selected parties and political leaders; assessment of the state of the economy in the country; assessment of economic development in the country; degree of improvement or deterioration of economy; politicians know what people think; contact with a member of parliament or congress during the past twelve months; attitude towards selected statements: it makes a difference who is in power and who people vote for; people express their political opinion; self-assessment on a left-right-scale; assessment of parties and political leaders on a left-right-scale; political information items DISTRICT-LEVEL DATA: number of seats contested in electoral district; number of candidates; number of party lists; percent vote of different parties; official voter turnout in electoral district MACRO-LEVEL DATA: founding year of parties; ideological families of parties; international organization the parties belong to; left-right position of parties assigned by experts; election outcomes by parties in current (lower house/upper house) legislative election; percent of seats in lower house received by parties in current lower house/upper house election; percent of seats in upper house received by parties in current lower house/upper house election; percent of votes received by presidential candidate of parties in current elections; electoral turnout; electoral alliances permitted during the election campaign; existing electoral alliances; most salient factors in the election; head of state (regime type); if multiple rounds: selection of head of state; direct election of head of state and process of direct election; threshold for first-round victory; procedure for candidate selection at final round; simple majority or absolute majority for 2nd round victory; year of presidential election (before or after this legislative election); process if indirect election of head of state; head of government (president or prime minister); selection of prime minister; number of elected legislative chambers; for lower and upper houses was coded: number of electoral segments; number of primary districts; number of seats; district magnitude (number of members elected from each district); number of secondary and tertiary electoral districts; compulsory voting; votes cast; voting procedure; electoral formula; party threshold; parties can run joint lists; requirements for joint party lists; possibility of apparentement; types of apparentement agreements; multi-party endorsements; multi-party endorsements on ballot; ally party support; constitutional prerogatives of the head of state; constitutional powers of prime minister; methods of cabinet dismissal; dissolution of legislatur